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@article{1592820,
author = {Micenková, Lenka and Bosák, Juraj and Kučera, Jiří and Hrala, Matěj and Dolejsova, Tereza and Šedo, Ondrej and Linke, Dirk and Fiser, Radovan and Šmajs, David},
article_location = {LONDON},
article_number = {JUL 31 2019},
doi = {http://dx.doi.org/10.1038/s41598-019-47488-8},
keywords = {NUCLEOTIDE-SEQUENCE; BACTERIAL; IMMUNITY; DOMAIN; GENES; ORGANIZATION; PYOCINS; IMPORT; DNA},
language = {eng},
issn = {2045-2322},
journal = {Scientific reports},
title = {Colicin Z, a structurally and functionally novel colicin type that selectively kills enteroinvasive Escherichia coli and Shigella strains},
url = {https://www.nature.com/articles/s41598-019-47488-8.pdf},
volume = {9},
year = {2019}
}
TY - JOUR
ID - 1592820
AU - Micenková, Lenka - Bosák, Juraj - Kučera, Jiří - Hrala, Matěj - Dolejsova, Tereza - Šedo, Ondrej - Linke, Dirk - Fiser, Radovan - Šmajs, David
PY - 2019
TI - Colicin Z, a structurally and functionally novel colicin type that selectively kills enteroinvasive Escherichia coli and Shigella strains
JF - Scientific reports
VL - 9
IS - JUL 31 2019
SP - 1-12
EP - 1-12
PB - NATURE PUBLISHING GROUP
SN - 20452322
KW - NUCLEOTIDE-SEQUENCE
KW - BACTERIAL
KW - IMMUNITY
KW - DOMAIN
KW - GENES
KW - ORGANIZATION
KW - PYOCINS
KW - IMPORT
KW - DNA
UR - https://www.nature.com/articles/s41598-019-47488-8.pdf
L2 - https://www.nature.com/articles/s41598-019-47488-8.pdf
N2 - Colicin production in Escherichia coli (E. coli) strains represents an important trait with regard to microbial survival and competition in the complex intestinal environment. A novel colicin type, colicin Z (26.3 kDa), was described as a product of an original producer, extraintestinal E. coli B1356 strain, isolated from the anorectal abscess of a 17 years-old man. The 4,007 bp plasmid (pColZ) was completely sequenced and colicin Z activity (cza) and colicin Z immunity (czi) genes were identified. The cza and czi genes are transcribed in opposite directions and encode for 237 and 151 amino acid-long proteins, respectively. Colicin Z shows a narrow inhibitory spectrum, being active only against enteroinvasive E. coli (EIEC) and Shigella strains via CjrC receptor recognition and CjrB- and ExbB-, ExbD-mediated colicin translocation. All tested EIEC and Shigella strains isolated between the years 1958-2010 were sensitive to colicin Z. The lethal effect of colicin Z was found to be directed against cell wall peptidoglycan (PG) resulting in PG degradation, as revealed by experiments with Remazol Brilliant Blue-stained purified peptidoglycans and with MALDI-TOF MS analyses of treated PG. Colicin Z represents a new class of colicins that is structurally and functionally distinct from previously studied colicin types.
ER -
MICENKOVÁ, Lenka, Juraj BOSÁK, Jiří KUČERA, Matěj HRALA, Tereza DOLEJSOVA, Ondrej ŠEDO, Dirk LINKE, Radovan FISER and David ŠMAJS. Colicin Z, a structurally and functionally novel colicin type that selectively kills enteroinvasive Escherichia coli and Shigella strains. \textit{Scientific reports}. LONDON: NATURE PUBLISHING GROUP, 2019, vol.~9, JUL 31 2019, p.~1-12. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-019-47488-8.
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