| MOLDOVAN, Dumitru, Jonathan A. BERNSTEIN, Roman HAKL, Grzegorz POREBSKI, Kimberly POARCH, William R. LUMRY and Anurag RELAN. Safety of recombinant human C1 esterase inhibitor for hereditary angioedema attacks during pregnancy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. AMSTERDAM: ELSEVIER, 2019, vol. 7, No 8, p. 2938-2940. ISSN 2213-2198. Available from: https://dx.doi.org/10.1016/j.jaip.2019.05.042. |
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@article{1593096,
author = {Moldovan, Dumitru and Bernstein, Jonathan A. and Hakl, Roman and Porebski, Grzegorz and Poarch, Kimberly and Lumry, William R. and Relan, Anurag},
article_location = {AMSTERDAM},
article_number = {8},
doi = {http://dx.doi.org/10.1016/j.jaip.2019.05.042},
keywords = {C1-INHIBITOR CONCENTRATE},
language = {eng},
issn = {2213-2198},
journal = {JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE},
title = {Safety of recombinant human C1 esterase inhibitor for hereditary angioedema attacks during pregnancy},
url = {http://dx.doi.org/10.1016/j.jaip.2019.05.042},
volume = {7},
year = {2019}
}
TY - JOUR
ID - 1593096
AU - Moldovan, Dumitru - Bernstein, Jonathan A. - Hakl, Roman - Porebski, Grzegorz - Poarch, Kimberly - Lumry, William R. - Relan, Anurag
PY - 2019
TI - Safety of recombinant human C1 esterase inhibitor for hereditary angioedema attacks during pregnancy
JF - JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
VL - 7
IS - 8
SP - 2938-2940
EP - 2938-2940
PB - ELSEVIER
SN - 22132198
KW - C1-INHIBITOR CONCENTRATE
UR - http://dx.doi.org/10.1016/j.jaip.2019.05.042
L2 - http://dx.doi.org/10.1016/j.jaip.2019.05.042
N2 - Hereditary angioedema (HAE) is a rare (<1 in 50,000) ge-netic disorder characterized by episodes of cutaneous andmucosal angioedema. HAE is caused by insufficient suppressionof complement and contact-system cascades due to a deficiencyof functional C1 inhibitor (C1-INH). It has been demonstratedthat HAE abdominal attacks are more frequent during preg-nancy, but there is no consensus on which trimester is mostassociated with increased attack rates.Some data suggest thatmore severe attacks and symptoms occur during thefirsttrimester, whereas other data suggest a greater number of attacksin the second and third trimesters. Changes in hormone levelsduring pregnancy may exacerbate HAE attacks, and concernswith administration of certain medications during pregnancy cancomplicate HAE management.
ER -
MOLDOVAN, Dumitru, Jonathan A. BERNSTEIN, Roman HAKL, Grzegorz POREBSKI, Kimberly POARCH, William R. LUMRY and Anurag RELAN. Safety of recombinant human C1 esterase inhibitor for hereditary angioedema attacks during pregnancy. \textit{JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE}. AMSTERDAM: ELSEVIER, 2019, vol.~7, No~8, p.~2938-2940. ISSN~2213-2198. Available from: https://dx.doi.org/10.1016/j.jaip.2019.05.042.
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