Detailed Information on Publication Record
2019
Hyperglycemia potentiates the effect of ionic calcium in photoreceptor ellipsoid zone disruption in diabetic retinopathy
ANKITA, Ankita, Jana STEFANICKOVA, Sandeep SAXENA, Dwividendra K. NIM, Kaleem AHMAD et. al.Basic information
Original name
Hyperglycemia potentiates the effect of ionic calcium in photoreceptor ellipsoid zone disruption in diabetic retinopathy
Authors
ANKITA, Ankita (356 India), Jana STEFANICKOVA (703 Slovakia), Sandeep SAXENA (356 India, guarantor), Dwividendra K. NIM (356 India), Kaleem AHMAD (356 India), Abbas A. MAHDI (356 India), Apjit KAUR (356 India), Shashi K. BHASKER (356 India), Jela VALASKOVA (703 Slovakia) and Peter KRUŽLIAK (703 Slovakia, belonging to the institution)
Edition
INTERNATIONAL OPHTHALMOLOGY, DORDRECHT, SPRINGER, 2019, 0165-5701
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30207 Ophthalmology
Country of publisher
Netherlands
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 1.314
RIV identification code
RIV/00216224:14110/19:00111747
Organization unit
Faculty of Medicine
UT WoS
000491942400011
Keywords in English
Diabetic retinopathy; Glycated hemoglobin; Serum calcium; Spectral-domain optical coherence tomography; Ellipsoid zone
Tags
International impact, Reviewed
Změněno: 16/1/2020 14:32, Mgr. Tereza Miškechová
Abstract
V originále
PurposeTo study the association of serum ionic calcium and glycated hemoglobin (HbA1c) with retinal photoreceptor ellipsoid zone (EZ) disruption in diabetic retinopathy (DR). MethodsThis is a tertiary care center-based observational cross-sectional study. Sixty-three consecutive cases, divided into 21 cases each with no diabetic retinopathy, non-proliferative diabetic retinopathy and proliferative diabetic retinopathy were included. Twenty-one healthy controls were also included. Ellipsoid zone disruption was assessed using spectral-domain optical coherence tomography. Serum ionic calcium and HbA1c were measured using standard protocol. Patient data from cases were divided into two groups according to their HbA1c levels: group 1 (HbA1c<7, n=26) and group 2 (HbA1c>7, n=37). Data were analyzed statistically.ResultsMean ionic calcium levels in group 1 and group 2 were 1.1310.073 mmol/dL and 1.170 +/- 0.070 mmol/dL, respectively. In group 1, 11 out of 26 had EZ disruption (42.3%). Similarly, in group 2, 29 out of 37 had EZ disruption (78.4%). On logistic regression analysis, as compared to group 1, ellipsoid zone disruption was found to be positively associated with serum ionic calcium (p=0.01) in group 2 cases.Conclusionp id=ParIncreased levels of serum ionic calcium are associated with increased EZ disruption in patients with HbA1c>7 in DR.