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@article{1593136,
author = {Ankita, Ankita and Stefanickova, Jana and Saxena, Sandeep and Nim, Dwividendra K. and Ahmad, Kaleem and Mahdi, Abbas A. and Kaur, Apjit and Bhasker, Shashi K. and Valaskova, Jela and Kružliak, Peter},
article_location = {DORDRECHT},
article_number = {10},
doi = {http://dx.doi.org/10.1007/s10792-018-01063-8},
keywords = {Diabetic retinopathy; Glycated hemoglobin; Serum calcium; Spectral-domain optical coherence tomography; Ellipsoid zone},
language = {eng},
issn = {0165-5701},
journal = {INTERNATIONAL OPHTHALMOLOGY},
title = {Hyperglycemia potentiates the effect of ionic calcium in photoreceptor ellipsoid zone disruption in diabetic retinopathy},
url = {http://dx.doi.org/10.1007/s10792-018-01063-8},
volume = {39},
year = {2019}
}
TY - JOUR
ID - 1593136
AU - Ankita, Ankita - Stefanickova, Jana - Saxena, Sandeep - Nim, Dwividendra K. - Ahmad, Kaleem - Mahdi, Abbas A. - Kaur, Apjit - Bhasker, Shashi K. - Valaskova, Jela - Kružliak, Peter
PY - 2019
TI - Hyperglycemia potentiates the effect of ionic calcium in photoreceptor ellipsoid zone disruption in diabetic retinopathy
JF - INTERNATIONAL OPHTHALMOLOGY
VL - 39
IS - 10
SP - 2237-2243
EP - 2237-2243
PB - SPRINGER
SN - 01655701
KW - Diabetic retinopathy
KW - Glycated hemoglobin
KW - Serum calcium
KW - Spectral-domain optical coherence tomography
KW - Ellipsoid zone
UR - http://dx.doi.org/10.1007/s10792-018-01063-8
L2 - http://dx.doi.org/10.1007/s10792-018-01063-8
N2 - PurposeTo study the association of serum ionic calcium and glycated hemoglobin (HbA1c) with retinal photoreceptor ellipsoid zone (EZ) disruption in diabetic retinopathy (DR). MethodsThis is a tertiary care center-based observational cross-sectional study. Sixty-three consecutive cases, divided into 21 cases each with no diabetic retinopathy, non-proliferative diabetic retinopathy and proliferative diabetic retinopathy were included. Twenty-one healthy controls were also included. Ellipsoid zone disruption was assessed using spectral-domain optical coherence tomography. Serum ionic calcium and HbA1c were measured using standard protocol. Patient data from cases were divided into two groups according to their HbA1c levels: group 1 (HbA1c<7, n=26) and group 2 (HbA1c>7, n=37). Data were analyzed statistically.ResultsMean ionic calcium levels in group 1 and group 2 were 1.1310.073 mmol/dL and 1.170 +/- 0.070 mmol/dL, respectively. In group 1, 11 out of 26 had EZ disruption (42.3%). Similarly, in group 2, 29 out of 37 had EZ disruption (78.4%). On logistic regression analysis, as compared to group 1, ellipsoid zone disruption was found to be positively associated with serum ionic calcium (p=0.01) in group 2 cases.Conclusionp id=ParIncreased levels of serum ionic calcium are associated with increased EZ disruption in patients with HbA1c>7 in DR.
ER -
ANKITA, Ankita, Jana STEFANICKOVA, Sandeep SAXENA, Dwividendra K. NIM, Kaleem AHMAD, Abbas A. MAHDI, Apjit KAUR, Shashi K. BHASKER, Jela VALASKOVA and Peter KRUŽLIAK. Hyperglycemia potentiates the effect of ionic calcium in photoreceptor ellipsoid zone disruption in diabetic retinopathy. \textit{INTERNATIONAL OPHTHALMOLOGY}. DORDRECHT: SPRINGER, 2019, vol.~39, No~10, p.~2237-2243. ISSN~0165-5701. Available from: https://dx.doi.org/10.1007/s10792-018-01063-8.
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