Altered Electroencephalographic Resting-State Large-Scale Brain Network Dynamics in Euthymic ...

@article{1593256,
   author = {Damborská, Alena and Piguet, Camille and Aubry, JeanandMichel and Dayer, Alexandre G. and Michel, Christoph M. and Berchio, Cristina},
   article_location = {Lausanne},
   article_number = {NOV 15 2019},
   doi = {http://dx.doi.org/10.3389/fpsyt.2019.00826},
   keywords = {electroencephalographic microstate; large-scale brain networks; resting state; dynamic brain activity; bipolar disorder; high-density electroencephalography},
   language = {eng},
   issn = {1664-0640},
   journal = {Frontiers in Psychiatry},
   title = {Altered Electroencephalographic Resting-State Large-Scale Brain Network Dynamics in Euthymic Bipolar Disorder Patients},
   url = {http://dx.doi.org/10.3389/fpsyt.2019.00826},
   volume = {10},
   year = {2019}
}

TY  - JOUR
ID  - 1593256
AU  - Damborská, Alena - Piguet, Camille - Aubry, Jean-Michel - Dayer, Alexandre G. - Michel, Christoph M. - Berchio, Cristina
PY  - 2019
TI  - Altered Electroencephalographic Resting-State Large-Scale Brain Network Dynamics in Euthymic Bipolar Disorder Patients
JF  - Frontiers in Psychiatry
VL  - 10
IS  - NOV 15 2019
SP  - 1-10
EP  - 1-10
PB  - Frontiers
SN  - 16640640
KW  - electroencephalographic microstate
KW  - large-scale brain networks
KW  - resting state
KW  - dynamic brain activity
KW  - bipolar disorder
KW  - high-density electroencephalography
UR  - http://dx.doi.org/10.3389/fpsyt.2019.00826
L2  - http://dx.doi.org/10.3389/fpsyt.2019.00826
N2  - Background: Neuroimaging studies provided evidence for disrupted resting-state functional brain network activity in bipolar disorder (BD). Electroencephalographic (EEG) studies found altered temporal characteristics of functional EEG microstates during depressive episode within different affective disorders. Here we investigated whether euthymic patients with BD show deviant resting-state large-scale brain network dynamics as reflected by altered temporal characteristics of EEG microstates. Methods: We used high-density EEG to explore between-group differences in duration, coverage, and occurrence of the resting-state functional EEG microstates in 17 euthymic adults with BD in on-medication state and 17 age- and gender-matched healthy controls. Two types of anxiety, state and trait, were assessed separately with scores ranging from 20 to 80. Results: Microstate analysis revealed five microstates (A-E) in global clustering across all subjects. In patients compared to controls, we found increased occurrence and coverage of microstate A that did not significantly correlate with anxiety scores. Conclusion: Our results provide neurophysiological evidence for altered large-scale brain network dynamics in BD patients and suggest the increased presence of A microstate to be an electrophysiological trait characteristic of BD.
ER  - 

DAMBORSKÁ, Alena, Camille PIGUET, Jean-Michel AUBRY, Alexandre G. DAYER, Christoph M. MICHEL a Cristina BERCHIO. Altered Electroencephalographic Resting-State Large-Scale Brain Network Dynamics in Euthymic Bipolar Disorder Patients. \textit{Frontiers in Psychiatry}. Lausanne: Frontiers, roč.~10, NOV 15 2019, s.~1-10. ISSN~1664-0640. doi:10.3389/fpsyt.2019.00826. 2019.