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@article{1593836, author = {Vondrak, Jiri and Marek, Dan and Vecera, Jan and Benešová, Klára and Matejka, Jan}, article_location = {ATHENS}, article_number = {1}, doi = {http://dx.doi.org/10.1016/j.hjc.2017.11.003}, keywords = {3D echocardiography; cardiac resynchronisation therapy; systolic dyssynchrony index}, language = {eng}, issn = {1109-9666}, journal = {HELLENIC JOURNAL OF CARDIOLOGY}, title = {Cardiac resynchronisation therapy optimisation of interventricular delay by the systolic dyssynchrony index: A comparative, randomised, 12-month follow-up study}, url = {http://dx.doi.org/10.1016/j.hjc.2017.11.003}, volume = {60}, year = {2019} }
TY - JOUR ID - 1593836 AU - Vondrak, Jiri - Marek, Dan - Vecera, Jan - Benešová, Klára - Matejka, Jan PY - 2019 TI - Cardiac resynchronisation therapy optimisation of interventricular delay by the systolic dyssynchrony index: A comparative, randomised, 12-month follow-up study JF - HELLENIC JOURNAL OF CARDIOLOGY VL - 60 IS - 1 SP - 16-25 EP - 16-25 PB - HELLENIC CARDIOLOGICAL SOC SN - 11099666 KW - 3D echocardiography KW - cardiac resynchronisation therapy KW - systolic dyssynchrony index UR - http://dx.doi.org/10.1016/j.hjc.2017.11.003 L2 - http://dx.doi.org/10.1016/j.hjc.2017.11.003 N2 - Background: The aim of our study was to compare the effect of interventricular (VV) delay optimisation in CRT recipients on the basis of systolic dyssynchrony index (SDI) derived from the three-dimensional echocardiography (3DE) versus QRS width assessment on left ventricle volume reduction at the 12-month follow-up. Methods: We included 63 patients with recently implanted CRT in this randomised, open-label trial. Patients were randomised to VV delay optimisation according to QRS complex width measurement in group 1 (n = 31) to obtain the narrowest QRS complex and SDI in group 2 (n = 32) to achieve its lowest possible value. We evaluated left ventricular end-systolic volume (LVESv), left ventricular ejection fraction (LVEF) and SDI by 3DE before CRT implantation and at a 12-month follow-up in all the patients. We also obtained the New York Heart Association functional class, the 6-minute walk test, the quality of life questionnaire and the level of NT-proBNP. Results: The number of volumetric responders was similar in both groups (17 vs. 20, P = 0.786). There were also no significant differences in the reduction of LVESv (-41 +/- 55 mL vs. - 61 +/- 51 mL, P = 0.111), improvement in LVEF (+10.1 +/- 10.6% vs. + 13.0 +/- 9.9%, P = 0.213) or differences in clinical outcomes between both groups at the 12-month follow-up. Conclusion: CRT optimisation of interventricular delay using SDI compared with QRS width assessment did not reveal any significant difference in terms of volumetric and clinical response at the 12-month follow-up. (C) 2017 Hellenic Society of Cardiology. Publishing services by Elsevier B.V. ER -
VONDRAK, Jiri, Dan MAREK, Jan VECERA, Klára BENEŠOVÁ and Jan MATEJKA. Cardiac resynchronisation therapy optimisation of interventricular delay by the systolic dyssynchrony index: A comparative, randomised, 12-month follow-up study. \textit{HELLENIC JOURNAL OF CARDIOLOGY}. ATHENS: HELLENIC CARDIOLOGICAL SOC, 2019, vol.~60, No~1, p.~16-25. ISSN~1109-9666. Available from: https://dx.doi.org/10.1016/j.hjc.2017.11.003.
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