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@article{1593836,
author = {Vondrak, Jiri and Marek, Dan and Vecera, Jan and Benešová, Klára and Matejka, Jan},
article_location = {ATHENS},
article_number = {1},
doi = {http://dx.doi.org/10.1016/j.hjc.2017.11.003},
keywords = {3D echocardiography; cardiac resynchronisation therapy; systolic dyssynchrony index},
language = {eng},
issn = {1109-9666},
journal = {HELLENIC JOURNAL OF CARDIOLOGY},
title = {Cardiac resynchronisation therapy optimisation of interventricular delay by the systolic dyssynchrony index: A comparative, randomised, 12-month follow-up study},
url = {http://dx.doi.org/10.1016/j.hjc.2017.11.003},
volume = {60},
year = {2019}
}
TY - JOUR
ID - 1593836
AU - Vondrak, Jiri - Marek, Dan - Vecera, Jan - Benešová, Klára - Matejka, Jan
PY - 2019
TI - Cardiac resynchronisation therapy optimisation of interventricular delay by the systolic dyssynchrony index: A comparative, randomised, 12-month follow-up study
JF - HELLENIC JOURNAL OF CARDIOLOGY
VL - 60
IS - 1
SP - 16-25
EP - 16-25
PB - HELLENIC CARDIOLOGICAL SOC
SN - 11099666
KW - 3D echocardiography
KW - cardiac resynchronisation therapy
KW - systolic dyssynchrony index
UR - http://dx.doi.org/10.1016/j.hjc.2017.11.003
L2 - http://dx.doi.org/10.1016/j.hjc.2017.11.003
N2 - Background: The aim of our study was to compare the effect of interventricular (VV) delay optimisation in CRT recipients on the basis of systolic dyssynchrony index (SDI) derived from the three-dimensional echocardiography (3DE) versus QRS width assessment on left ventricle volume reduction at the 12-month follow-up. Methods: We included 63 patients with recently implanted CRT in this randomised, open-label trial. Patients were randomised to VV delay optimisation according to QRS complex width measurement in group 1 (n = 31) to obtain the narrowest QRS complex and SDI in group 2 (n = 32) to achieve its lowest possible value. We evaluated left ventricular end-systolic volume (LVESv), left ventricular ejection fraction (LVEF) and SDI by 3DE before CRT implantation and at a 12-month follow-up in all the patients. We also obtained the New York Heart Association functional class, the 6-minute walk test, the quality of life questionnaire and the level of NT-proBNP. Results: The number of volumetric responders was similar in both groups (17 vs. 20, P = 0.786). There were also no significant differences in the reduction of LVESv (-41 +/- 55 mL vs. - 61 +/- 51 mL, P = 0.111), improvement in LVEF (+10.1 +/- 10.6% vs. + 13.0 +/- 9.9%, P = 0.213) or differences in clinical outcomes between both groups at the 12-month follow-up. Conclusion: CRT optimisation of interventricular delay using SDI compared with QRS width assessment did not reveal any significant difference in terms of volumetric and clinical response at the 12-month follow-up. (C) 2017 Hellenic Society of Cardiology. Publishing services by Elsevier B.V.
ER -
VONDRAK, Jiri, Dan MAREK, Jan VECERA, Klára BENEŠOVÁ and Jan MATEJKA. Cardiac resynchronisation therapy optimisation of interventricular delay by the systolic dyssynchrony index: A comparative, randomised, 12-month follow-up study. \textit{HELLENIC JOURNAL OF CARDIOLOGY}. ATHENS: HELLENIC CARDIOLOGICAL SOC, 2019, vol.~60, No~1, p.~16-25. ISSN~1109-9666. Available from: https://dx.doi.org/10.1016/j.hjc.2017.11.003.
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