Cardiac resynchronisation therapy optimisation of
interventricular delay by the systolic dyssynchrony index: A
comparative, randomised, 12-month follow-up study

J 2019

Cardiac resynchronisation therapy optimisation of interventricular delay by the systolic dyssynchrony index: A comparative, randomised, 12-month follow-up study

VONDRAK, Jiri, Dan MAREK, Jan VECERA, Klára BENEŠOVÁ, Jan MATEJKA et. al.

Basic information

Original name

Cardiac resynchronisation therapy optimisation of interventricular delay by the systolic dyssynchrony index: A comparative, randomised, 12-month follow-up study

Authors

VONDRAK, Jiri (203 Czech Republic, guarantor), Dan MAREK, Jan VECERA, Klára BENEŠOVÁ (203 Czech Republic, belonging to the institution) and Jan MATEJKA

Edition

HELLENIC JOURNAL OF CARDIOLOGY, ATHENS, HELLENIC CARDIOLOGICAL SOC, 2019, 1109-9666

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

Greece

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.047

RIV identification code

RIV/00216224:14110/19:00111775

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.hjc.2017.11.003

UT WoS

000473281500004

Keywords in English

3D echocardiography; cardiac resynchronisation therapy; systolic dyssynchrony index

Abstract

V originále

Background: The aim of our study was to compare the effect of interventricular (VV) delay optimisation in CRT recipients on the basis of systolic dyssynchrony index (SDI) derived from the three-dimensional echocardiography (3DE) versus QRS width assessment on left ventricle volume reduction at the 12-month follow-up. Methods: We included 63 patients with recently implanted CRT in this randomised, open-label trial. Patients were randomised to VV delay optimisation according to QRS complex width measurement in group 1 (n = 31) to obtain the narrowest QRS complex and SDI in group 2 (n = 32) to achieve its lowest possible value. We evaluated left ventricular end-systolic volume (LVESv), left ventricular ejection fraction (LVEF) and SDI by 3DE before CRT implantation and at a 12-month follow-up in all the patients. We also obtained the New York Heart Association functional class, the 6-minute walk test, the quality of life questionnaire and the level of NT-proBNP. Results: The number of volumetric responders was similar in both groups (17 vs. 20, P = 0.786). There were also no significant differences in the reduction of LVESv (-41 +/- 55 mL vs. - 61 +/- 51 mL, P = 0.111), improvement in LVEF (+10.1 +/- 10.6% vs. + 13.0 +/- 9.9%, P = 0.213) or differences in clinical outcomes between both groups at the 12-month follow-up. Conclusion: CRT optimisation of interventricular delay using SDI compared with QRS width assessment did not reveal any significant difference in terms of volumetric and clinical response at the 12-month follow-up. (C) 2017 Hellenic Society of Cardiology. Publishing services by Elsevier B.V.

Citovat

VONDRAK, Jiri, Dan MAREK, Jan VECERA, Klára BENEŠOVÁ and Jan MATEJKA. Cardiac resynchronisation therapy optimisation of interventricular delay by the systolic dyssynchrony index: A comparative, randomised, 12-month follow-up study. HELLENIC JOURNAL OF CARDIOLOGY. ATHENS: HELLENIC CARDIOLOGICAL SOC, 2019, vol. 60, No 1, p. 16-25. ISSN 1109-9666. Available from: https://dx.doi.org/10.1016/j.hjc.2017.11.003.

@article{1593836,
   author = {Vondrak, Jiri and Marek, Dan and Vecera, Jan and Benešová, Klára and Matejka, Jan},
   article_location = {ATHENS},
   article_number = {1},
   doi = {http://dx.doi.org/10.1016/j.hjc.2017.11.003},
   keywords = {3D echocardiography; cardiac resynchronisation therapy; systolic dyssynchrony index},
   language = {eng},
   issn = {1109-9666},
   journal = {HELLENIC JOURNAL OF CARDIOLOGY},
   title = {Cardiac resynchronisation therapy optimisation of interventricular delay by the systolic dyssynchrony index: A comparative, randomised, 12-month follow-up study},
   url = {http://dx.doi.org/10.1016/j.hjc.2017.11.003},
   volume = {60},
   year = {2019}
}

TY  - JOUR
ID  - 1593836
AU  - Vondrak, Jiri - Marek, Dan - Vecera, Jan - Benešová, Klára - Matejka, Jan
PY  - 2019
TI  - Cardiac resynchronisation therapy optimisation of interventricular delay by the systolic dyssynchrony index: A comparative, randomised, 12-month follow-up study
JF  - HELLENIC JOURNAL OF CARDIOLOGY
VL  - 60
IS  - 1
SP  - 16-25
EP  - 16-25
PB  - HELLENIC CARDIOLOGICAL SOC
SN  - 11099666
KW  - 3D echocardiography
KW  - cardiac resynchronisation therapy
KW  - systolic dyssynchrony index
UR  - http://dx.doi.org/10.1016/j.hjc.2017.11.003
L2  - http://dx.doi.org/10.1016/j.hjc.2017.11.003
N2  - Background: The aim of our study was to compare the effect of interventricular (VV) delay optimisation in CRT recipients on the basis of systolic dyssynchrony index (SDI) derived from the three-dimensional echocardiography (3DE) versus QRS width assessment on left ventricle volume reduction at the 12-month follow-up. Methods: We included 63 patients with recently implanted CRT in this randomised, open-label trial. Patients were randomised to VV delay optimisation according to QRS complex width measurement in group 1 (n = 31) to obtain the narrowest QRS complex and SDI in group 2 (n = 32) to achieve its lowest possible value. We evaluated left ventricular end-systolic volume (LVESv), left ventricular ejection fraction (LVEF) and SDI by 3DE before CRT implantation and at a 12-month follow-up in all the patients. We also obtained the New York Heart Association functional class, the 6-minute walk test, the quality of life questionnaire and the level of NT-proBNP. Results: The number of volumetric responders was similar in both groups (17 vs. 20, P = 0.786). There were also no significant differences in the reduction of LVESv (-41 +/- 55 mL vs. - 61 +/- 51 mL, P = 0.111), improvement in LVEF (+10.1 +/- 10.6% vs. + 13.0 +/- 9.9%, P = 0.213) or differences in clinical outcomes between both groups at the 12-month follow-up. Conclusion: CRT optimisation of interventricular delay using SDI compared with QRS width assessment did not reveal any significant difference in terms of volumetric and clinical response at the 12-month follow-up. (C) 2017 Hellenic Society of Cardiology. Publishing services by Elsevier B.V.
ER  -

VONDRAK, Jiri, Dan MAREK, Jan VECERA, Klára BENEŠOVÁ and Jan MATEJKA. Cardiac resynchronisation therapy optimisation of interventricular delay by the systolic dyssynchrony index: A comparative, randomised, 12-month follow-up study. \textit{HELLENIC JOURNAL OF CARDIOLOGY}. ATHENS: HELLENIC CARDIOLOGICAL SOC, 2019, vol.~60, No~1, p.~16-25. ISSN~1109-9666. Available from: https://dx.doi.org/10.1016/j.hjc.2017.11.003.

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