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@article{1594076,
author = {Ciccocioppo, Rachele and Bozzini, Sara and Betti, Elena and Imbesi, Venerina and Klersy, Catherine and Lakyova Sukovska, Lucia and Sukovsky, Lukas and Benacka, Jozef and Kružliak, Peter and Corazza, Gino Roberto and Di Sabatino, Antonio and Falcone, Colomba},
article_location = {Milan},
article_number = {3},
doi = {http://dx.doi.org/10.1007/s10238-019-00562-x},
keywords = {Gene polymorphisms; Inflammatory bowel disease; RAGE},
language = {eng},
issn = {1591-8890},
journal = {Clinical and Experimental Medicine},
title = {Functional polymorphisms of the receptor for the advanced glycation end product promoter gene in inflammatory bowel disease: a case-control study},
url = {http://dx.doi.org/10.1007/s10238-019-00562-x},
volume = {19},
year = {2019}
}
TY - JOUR
ID - 1594076
AU - Ciccocioppo, Rachele - Bozzini, Sara - Betti, Elena - Imbesi, Venerina - Klersy, Catherine - Lakyova Sukovska, Lucia - Sukovsky, Lukas - Benacka, Jozef - Kružliak, Peter - Corazza, Gino Roberto - Di Sabatino, Antonio - Falcone, Colomba
PY - 2019
TI - Functional polymorphisms of the receptor for the advanced glycation end product promoter gene in inflammatory bowel disease: a case-control study
JF - Clinical and Experimental Medicine
VL - 19
IS - 3
SP - 367-375
EP - 367-375
PB - SPRINGER-VERLAG ITALIA SRL
SN - 15918890
KW - Gene polymorphisms
KW - Inflammatory bowel disease
KW - RAGE
UR - http://dx.doi.org/10.1007/s10238-019-00562-x
L2 - http://dx.doi.org/10.1007/s10238-019-00562-x
N2 - The receptor for the advanced glycation end products (RAGE) is a multiligand transmembrane receptor involved in chronic inflammation whose specific polymorphisms of the promoter gene were found to increase its transcriptional activity. We investigated the association of both allelic and genotypic -374T/A and -429T/C polymorphisms with inflammatory bowel disease. The STREGA guidelines were applied for planning and reporting. We enrolled 133 patients with Crohn's disease (CD), 149 with ulcerative colitis (UC), and 128 blood donors. Genomic DNA was extracted from peripheral blood leukocytes collected from each patient and control. RAGE polymorphisms were analyzed by PCR-restriction fragment length polymorphism assay. The Hardy-Weinberg equilibrium was first assessed, and then, the Kruskal-Wallis test and the Fisher exact test were used for etiologic group comparisons. Distribution of patients' characteristics across genotypes was evaluated by the Fisher exact test, while that across alleles was analyzed with a probit model. A 2-sided value of p<0.05 was considered significant. Following the evidence of the Hardy-Weinberg equilibrium, we found a higher prevalence of the allele A of the -374T/A haplotype in UC (p=0.043), and of the allele C of the -429T/C haplotype in CD (p<0.001) with respect to the other groups. Moreover, the homozygous AA genotype of the -374T/A polymorphism resulted associated with late onset of CD, while its TT genotype with early onset (p=0.049). The allele C of the 429T/C haplotype was associated with early onset of UC (p=0.03), while a higher frequency of the heterozygous TC haplotype was found in those with pancolitis (p=0.026). The differing distribution of these polymorphisms in healthy donors and CD/UC patients suggests a role in the development and outcome of these pathological conditions.
ER -
CICCOCIOPPO, Rachele, Sara BOZZINI, Elena BETTI, Venerina IMBESI, Catherine KLERSY, Lucia LAKYOVA SUKOVSKA, Lukas SUKOVSKY, Jozef BENACKA, Peter KRUŽLIAK, Gino Roberto CORAZZA, Antonio DI SABATINO and Colomba FALCONE. Functional polymorphisms of the receptor for the advanced glycation end product promoter gene in inflammatory bowel disease: a case-control study. \textit{Clinical and Experimental Medicine}. Milan: SPRINGER-VERLAG ITALIA SRL, 2019, vol.~19, No~3, p.~367-375. ISSN~1591-8890. Available from: https://dx.doi.org/10.1007/s10238-019-00562-x.
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