Anti-Cancer Agents in Proliferation and Cell Death: The Calcium
Connection

J 2019

Anti-Cancer Agents in Proliferation and Cell Death: The Calcium Connection

VARGHESE, Elizabeth, Samson Mathews SAMUEL, Zuhair SADIQ, Peter KUBATKA, Alena LISKOVA et. al.

Basic information

Original name

Anti-Cancer Agents in Proliferation and Cell Death: The Calcium Connection

Authors

VARGHESE, Elizabeth (634 Qatar), Samson Mathews SAMUEL (634 Qatar), Zuhair SADIQ (634 Qatar), Peter KUBATKA (703 Slovakia), Alena LISKOVA (703 Slovakia), Jozef BENACKA (703 Slovakia), Peter PAZINKA (703 Slovakia), Peter KRUŽLIAK (703 Slovakia, belonging to the institution) and Dietrich BUSSELBERG (634 Qatar, guarantor)

Edition

International Journal of Molecular Sciences, Basel, Multidisciplinary Digital Publishing Institute, 2019, 1422-0067

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10608 Biochemistry and molecular biology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.556

RIV identification code

RIV/00216224:14110/19:00111781

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3390/ijms20123017

UT WoS

000473756000167

Keywords in English

Intracellular calcium; anti-cancer drugs; apoptosis; proliferation

Abstract

V originále

Calcium (Ca2+) signaling and the modulation of intracellular calcium ([Ca2+](i)) levels play critical roles in several key processes that regulate cellular survival, growth, differentiation, metabolism, and death in normal cells. On the other hand, aberrant Ca2+-signaling and loss of [Ca2+](i) homeostasis contributes to tumor initiation proliferation, angiogenesis, and other key processes that support tumor progression in several different cancers. Currently, chemically and functionally distinct drugs are used as chemotherapeutic agents in the treatment and management of cancer among which certain anti-cancer drugs reportedly suppress pro-survival signals and activate pro-apoptotic signaling through modulation of Ca2+-signaling-dependent mechanisms. Most importantly, the modulation of [Ca2+](i) levels via the endoplasmic reticulum-mitochondrial axis and corresponding action of channels and pumps within the plasma membrane play an important role in the survival and death of cancer cells. The endoplasmic reticulum-mitochondrial axis is of prime importance when considering Ca2+-signaling-dependent anti-cancer drug targets. This review discusses how calcium signaling is targeted by anti-cancer drugs and highlights the role of calcium signaling in epigenetic modification and the Warburg effect in tumorigenesis.

Citovat

VARGHESE, Elizabeth, Samson Mathews SAMUEL, Zuhair SADIQ, Peter KUBATKA, Alena LISKOVA, Jozef BENACKA, Peter PAZINKA, Peter KRUŽLIAK and Dietrich BUSSELBERG. Anti-Cancer Agents in Proliferation and Cell Death: The Calcium Connection. International Journal of Molecular Sciences. Basel: Multidisciplinary Digital Publishing Institute, 2019, vol. 20, No 12, p. 1-22. ISSN 1422-0067. Available from: https://dx.doi.org/10.3390/ijms20123017.

@article{1594096,
   author = {Varghese, Elizabeth and Samuel, Samson Mathews and Sadiq, Zuhair and Kubatka, Peter and Liskova, Alena and Benacka, Jozef and Pazinka, Peter and Kružliak, Peter and Busselberg, Dietrich},
   article_location = {Basel},
   article_number = {12},
   doi = {http://dx.doi.org/10.3390/ijms20123017},
   keywords = {Intracellular calcium; anti-cancer drugs; apoptosis; proliferation},
   language = {eng},
   issn = {1422-0067},
   journal = {International Journal of Molecular Sciences},
   title = {Anti-Cancer Agents in Proliferation and Cell Death: The Calcium Connection},
   url = {http://dx.doi.org/10.3390/ijms20123017},
   volume = {20},
   year = {2019}
}

TY  - JOUR
ID  - 1594096
AU  - Varghese, Elizabeth - Samuel, Samson Mathews - Sadiq, Zuhair - Kubatka, Peter - Liskova, Alena - Benacka, Jozef - Pazinka, Peter - Kružliak, Peter - Busselberg, Dietrich
PY  - 2019
TI  - Anti-Cancer Agents in Proliferation and Cell Death: The Calcium Connection
JF  - International Journal of Molecular Sciences
VL  - 20
IS  - 12
SP  - 1-22
EP  - 1-22
PB  - Multidisciplinary Digital Publishing Institute
SN  - 14220067
KW  - Intracellular calcium
KW  - anti-cancer drugs
KW  - apoptosis
KW  - proliferation
UR  - http://dx.doi.org/10.3390/ijms20123017
L2  - http://dx.doi.org/10.3390/ijms20123017
N2  - Calcium (Ca2+) signaling and the modulation of intracellular calcium ([Ca2+](i)) levels play critical roles in several key processes that regulate cellular survival, growth, differentiation, metabolism, and death in normal cells. On the other hand, aberrant Ca2+-signaling and loss of [Ca2+](i) homeostasis contributes to tumor initiation proliferation, angiogenesis, and other key processes that support tumor progression in several different cancers. Currently, chemically and functionally distinct drugs are used as chemotherapeutic agents in the treatment and management of cancer among which certain anti-cancer drugs reportedly suppress pro-survival signals and activate pro-apoptotic signaling through modulation of Ca2+-signaling-dependent mechanisms. Most importantly, the modulation of [Ca2+](i) levels via the endoplasmic reticulum-mitochondrial axis and corresponding action of channels and pumps within the plasma membrane play an important role in the survival and death of cancer cells. The endoplasmic reticulum-mitochondrial axis is of prime importance when considering Ca2+-signaling-dependent anti-cancer drug targets. This review discusses how calcium signaling is targeted by anti-cancer drugs and highlights the role of calcium signaling in epigenetic modification and the Warburg effect in tumorigenesis.
ER  -

VARGHESE, Elizabeth, Samson Mathews SAMUEL, Zuhair SADIQ, Peter KUBATKA, Alena LISKOVA, Jozef BENACKA, Peter PAZINKA, Peter KRUŽLIAK and Dietrich BUSSELBERG. Anti-Cancer Agents in Proliferation and Cell Death: The Calcium Connection. \textit{International Journal of Molecular Sciences}. Basel: Multidisciplinary Digital Publishing Institute, 2019, vol.~20, No~12, p.~1-22. ISSN~1422-0067. Available from: https://dx.doi.org/10.3390/ijms20123017.

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