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@article{1594096,
author = {Varghese, Elizabeth and Samuel, Samson Mathews and Sadiq, Zuhair and Kubatka, Peter and Liskova, Alena and Benacka, Jozef and Pazinka, Peter and Kružliak, Peter and Busselberg, Dietrich},
article_location = {Basel},
article_number = {12},
doi = {http://dx.doi.org/10.3390/ijms20123017},
keywords = {Intracellular calcium; anti-cancer drugs; apoptosis; proliferation},
language = {eng},
issn = {1422-0067},
journal = {International Journal of Molecular Sciences},
title = {Anti-Cancer Agents in Proliferation and Cell Death: The Calcium Connection},
url = {http://dx.doi.org/10.3390/ijms20123017},
volume = {20},
year = {2019}
}
TY - JOUR
ID - 1594096
AU - Varghese, Elizabeth - Samuel, Samson Mathews - Sadiq, Zuhair - Kubatka, Peter - Liskova, Alena - Benacka, Jozef - Pazinka, Peter - Kružliak, Peter - Busselberg, Dietrich
PY - 2019
TI - Anti-Cancer Agents in Proliferation and Cell Death: The Calcium Connection
JF - International Journal of Molecular Sciences
VL - 20
IS - 12
SP - 1-22
EP - 1-22
PB - Multidisciplinary Digital Publishing Institute
SN - 14220067
KW - Intracellular calcium
KW - anti-cancer drugs
KW - apoptosis
KW - proliferation
UR - http://dx.doi.org/10.3390/ijms20123017
L2 - http://dx.doi.org/10.3390/ijms20123017
N2 - Calcium (Ca2+) signaling and the modulation of intracellular calcium ([Ca2+](i)) levels play critical roles in several key processes that regulate cellular survival, growth, differentiation, metabolism, and death in normal cells. On the other hand, aberrant Ca2+-signaling and loss of [Ca2+](i) homeostasis contributes to tumor initiation proliferation, angiogenesis, and other key processes that support tumor progression in several different cancers. Currently, chemically and functionally distinct drugs are used as chemotherapeutic agents in the treatment and management of cancer among which certain anti-cancer drugs reportedly suppress pro-survival signals and activate pro-apoptotic signaling through modulation of Ca2+-signaling-dependent mechanisms. Most importantly, the modulation of [Ca2+](i) levels via the endoplasmic reticulum-mitochondrial axis and corresponding action of channels and pumps within the plasma membrane play an important role in the survival and death of cancer cells. The endoplasmic reticulum-mitochondrial axis is of prime importance when considering Ca2+-signaling-dependent anti-cancer drug targets. This review discusses how calcium signaling is targeted by anti-cancer drugs and highlights the role of calcium signaling in epigenetic modification and the Warburg effect in tumorigenesis.
ER -
VARGHESE, Elizabeth, Samson Mathews SAMUEL, Zuhair SADIQ, Peter KUBATKA, Alena LISKOVA, Jozef BENACKA, Peter PAZINKA, Peter KRUŽLIAK and Dietrich BUSSELBERG. Anti-Cancer Agents in Proliferation and Cell Death: The Calcium Connection. \textit{International Journal of Molecular Sciences}. Basel: Multidisciplinary Digital Publishing Institute, 2019, vol.~20, No~12, p.~1-22. ISSN~1422-0067. Available from: https://dx.doi.org/10.3390/ijms20123017.
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