| HOFER, Michal, Z HOFEROVÁ, A GRUZDEV, Ladislav DUŠEK and Martin FALK. Impaired post-irradiation survival of cyclooxygenase-2-deficient mice. Physiological Research. 2018, vol. 67, No 5, p. 809-812. |
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@article{1594202,
author = {Hofer, Michal and Hoferová, Z and Gruzdev, A and Dušek, Ladislav and Falk, Martin},
article_number = {5},
language = {eng},
journal = {Physiological Research},
title = {Impaired post-irradiation survival of cyclooxygenase-2-deficient mice},
volume = {67},
year = {2018}
}
TY - JOUR
ID - 1594202
AU - Hofer, Michal - Hoferová, Z - Gruzdev, A - Dušek, Ladislav - Falk, Martin
PY - 2018
TI - Impaired post-irradiation survival of cyclooxygenase-2-deficient mice
JF - Physiological Research
VL - 67
IS - 5
SP - 809-812
EP - 809-812
N2 - We investigated and evaluated post-irradiation survival in cyclooxygenase-2-deficient (COX-2 KO) mice. Thirty-day survival following exposure of COX-2 KO mice to a lethal dose of 8.5 Gy of γ-rays was observed to be statistically significantly lower in both males and females, as well as when the sexes were merged, in comparisons with their wild-type counterparts. These findings were related to the previous observations concerning the detrimental influence of the COX-2 genetic disruption on hematopoiesis in sublethally irradiated mice. Deteriorated postirradiation survival of COX-2 KO mice confirmed the previously anticipated conclusion regarding negative influence of the antiinflammatory action of COX-2 deficiency under the conditions of exposure of the animals to ionizing radiation.
ER -
HOFER, Michal, Z HOFEROVÁ, A GRUZDEV, Ladislav DUŠEK and Martin FALK. Impaired post-irradiation survival of cyclooxygenase-2-deficient mice. \textit{Physiological Research}. 2018, vol.~67, No~5, p.~809-812.
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