Pharmacological modulation of radiation damage. Does it exist a
chance for other substances thanhematopoietic growth factors
and cytokines?

J 2017

Pharmacological modulation of radiation damage. Does it exist a chance for other substances thanhematopoietic growth factors and cytokines?

HOFER, Michal, Z HOFEROVÁ and Martin FALK

Basic information

Original name

Pharmacological modulation of radiation damage. Does it exist a chance for other substances thanhematopoietic growth factors and cytokines?

Authors

HOFER, Michal, Z HOFEROVÁ and Martin FALK

Edition

International Journal of Molecular Sciences, Basel, Multidisciplinary Digital Publishing Institute, 2017, 1422-0067

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.687

DOI

http://dx.doi.org/10.3390/ijms18071385

UT WoS

000408746800057

Abstract

V originále

In recent times, cytokines and hematopoietic growth factors have been at the center of attention for many researchers trying to establish pharmacological therapeutic procedures for the treatment of radiation accident victims. Two granulocyte colony-stimulating factor-based radiation countermeasures have been approved for the treatment of the hematopoietic acute radiation syndrome. However, at the same time, many different substances with varying effects have been tested in animal studies as potential radioprotectors and mitigators of radiation damage. A wide spectrum of these substances has been studied, comprising various immunomodulators, prostaglandins, inhibitors of prostaglandin synthesis, agonists of adenosine cell receptors, herbal extracts, flavonoids, vitamins, and others. These agents are often effective, relatively non-toxic, and cheap. This review summarizes the results of animal experiments, which show the potential for some of these untraditional or new radiation countermeasures to become a part of therapeutic procedures applicable in patients with the acute radiation syndrome. The authors consider β-glucan, 5-AED (5-androstenediol), meloxicam, γ-tocotrienol, genistein, IB-MECA (N6-(3-iodobezyl)adenosine-5’-N-methyluronamide), Ex-RAD (4-carboxystyryl-4-chlorobenzylsulfone), and entolimod the most promising agents, with regards to their contingent use in clinical practice.

Links

GA16-12454S, research and development project

Name: Charakterizace a modifikace komplexní odpovědi buněk nádorů hlavy a krku na různá záření - krok kupředu ke kombinované personalizované (radio)terapii

Investor: Czech Science Foundation

NV16-29835A, research and development project

Name: Molekulárně-genetické markery predikce účinnosti radioterapie u nádorů hlavy a krku

Citovat

HOFER, Michal, Z HOFEROVÁ and Martin FALK. Pharmacological modulation of radiation damage. Does it exist a chance for other substances thanhematopoietic growth factors and cytokines? International Journal of Molecular Sciences. Basel: Multidisciplinary Digital Publishing Institute, 2017, vol. 18, No 7, p. art. no. 1385. ISSN 1422-0067. Available from: https://dx.doi.org/10.3390/ijms18071385.

@article{1594203,
   author = {Hofer, Michal and Hoferová, Z and Falk, Martin},
   article_location = {Basel},
   article_number = {7},
   doi = {http://dx.doi.org/10.3390/ijms18071385},
   language = {eng},
   issn = {1422-0067},
   journal = {International Journal of Molecular Sciences},
   title = {Pharmacological modulation of radiation damage. Does it exist a chance for other substances thanhematopoietic growth factors and cytokines?},
   url = {http://dx.doi.org/10.3390/ijms18071385},
   volume = {18},
   year = {2017}
}

TY  - JOUR
ID  - 1594203
AU  - Hofer, Michal - Hoferová, Z - Falk, Martin
PY  - 2017
TI  - Pharmacological modulation of radiation damage. Does it exist a chance for other substances thanhematopoietic growth factors and cytokines?
JF  - International Journal of Molecular Sciences
VL  - 18
IS  - 7
SP  - art. no. 1385
EP  - art. no. 1385
PB  - Multidisciplinary Digital Publishing Institute
SN  - 14220067
UR  - http://dx.doi.org/10.3390/ijms18071385
L2  - http://dx.doi.org/10.3390/ijms18071385
N2  - In recent times, cytokines and hematopoietic growth factors have been at the center of attention for many researchers trying to establish pharmacological therapeutic procedures for the treatment of radiation accident victims. Two granulocyte colony-stimulating factor-based radiation countermeasures have been approved for the treatment of the hematopoietic acute radiation syndrome. However, at the same time, many different substances with varying effects have been tested in animal studies as potential radioprotectors and mitigators of radiation damage. A wide spectrum of these substances has been studied, comprising various immunomodulators, prostaglandins, inhibitors of prostaglandin synthesis, agonists of adenosine cell receptors, herbal extracts, flavonoids, vitamins, and others. These agents are often effective, relatively non-toxic, and cheap. This review summarizes the results of animal experiments, which show the potential for some of these untraditional or new radiation countermeasures to become a part of therapeutic procedures applicable in patients with the acute radiation syndrome. The authors consider β-glucan, 5-AED (5-androstenediol), meloxicam, γ-tocotrienol, genistein, IB-MECA (N6-(3-iodobezyl)adenosine-5’-N-methyluronamide), Ex-RAD (4-carboxystyryl-4-chlorobenzylsulfone), and entolimod the most promising agents, with regards to their contingent use in clinical practice.
ER  -

HOFER, Michal, Z HOFEROVÁ and Martin FALK. Pharmacological modulation of radiation damage. Does it exist a chance for other substances thanhematopoietic growth factors and cytokines? \textit{International Journal of Molecular Sciences}. Basel: Multidisciplinary Digital Publishing Institute, 2017, vol.~18, No~7, p.~art. no. 1385. ISSN~1422-0067. Available from: https://dx.doi.org/10.3390/ijms18071385.

Detailed Information on Publication Record