| FALK, Martin, Emilie LUKÁŠOVÁ, Lenka ŠTEFANČÍKOVÁ, E BARANOVÁ, I FALKOVÁ, L JEŽKOVÁ, M Bačíková A DAVÍDKOVÁ, J VACHELOVÁ, A MICHAELIDESOVÁ and Stanislav KOZUBEK. Heterochromatinization associated with cell differentiation as a model to study DNA double strandbreak induction and repair in the context of higher-order chromatin structure. Applied Radiation and Isotopes. Elsevier, 2014, vol. 83, p. 177-185. ISSN 0969-8043. Available from: https://dx.doi.org/10.1016/j.apradiso.2013.01.029. |
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@article{1594217,
author = {Falk, Martin and Lukášová, Emilie and Štefančíková, Lenka and Baranová, E and Falková, I and Ježková, L and Davídková, M Bačíková A and Vachelová, J and Michaelidesová, A and Kozubek, Stanislav},
doi = {http://dx.doi.org/10.1016/j.apradiso.2013.01.029},
language = {eng},
issn = {0969-8043},
journal = {Applied Radiation and Isotopes},
title = {Heterochromatinization associated with cell differentiation as a model to study DNA double strandbreak induction and repair in the context of higher-order chromatin structure},
volume = {83},
year = {2014}
}
TY - JOUR
ID - 1594217
AU - Falk, Martin - Lukášová, Emilie - Štefančíková, Lenka - Baranová, E - Falková, I - Ježková, L - Davídková, M Bačíková A - Vachelová, J - Michaelidesová, A - Kozubek, Stanislav
PY - 2014
TI - Heterochromatinization associated with cell differentiation as a model to study DNA double strandbreak induction and repair in the context of higher-order chromatin structure
JF - Applied Radiation and Isotopes
VL - 83
SP - 177-185
EP - 177-185
PB - Elsevier
SN - 09698043
N2 - Cell differentiation is associated with extensive gene silencing, heterochromatinization and potentially decreasing need for repairing DNA double-strand breaks (DSBs). Differentiation stages of blood cells thus represent an excellent model to study DSB induction, repair and misrepair in the context of changing higher-order chromatin structure. We show that immature granulocytes form γH2AX and 53BP1 foci, contrary to the mature cells; however, these foci colocalize only rarely and DSB repair is inefficient. Moreover, specific chromatin structure of granulocytes probably influences DSB induction.
ER -
FALK, Martin, Emilie LUKÁŠOVÁ, Lenka ŠTEFANČÍKOVÁ, E BARANOVÁ, I FALKOVÁ, L JEŽKOVÁ, M Bačíková A DAVÍDKOVÁ, J VACHELOVÁ, A MICHAELIDESOVÁ and Stanislav KOZUBEK. Heterochromatinization associated with cell differentiation as a model to study DNA double strandbreak induction and repair in the context of higher-order chromatin structure. \textit{Applied Radiation and Isotopes}. Elsevier, 2014, vol.~83, p.~177-185. ISSN~0969-8043. Available from: https://dx.doi.org/10.1016/j.apradiso.2013.01.029.
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