HIC1 Expression Distinguishes Intestinal Carcinomas Sensitive
to Chemotherapy

J 2016

HIC1 Expression Distinguishes Intestinal Carcinomas Sensitive to Chemotherapy

JANECKOVA, Lucie, Michal KOLAR, Jiri SVEC, Lucie LANIKOVA, Vendula POSPÍCHALOVÁ et. al.

Basic information

Original name

HIC1 Expression Distinguishes Intestinal Carcinomas Sensitive to Chemotherapy

Authors

JANECKOVA, Lucie, Michal KOLAR, Jiri SVEC, Lucie LANIKOVA, Vendula POSPÍCHALOVÁ (203 Czech Republic, belonging to the institution), Nikol BALOGHOVA, Martina VOJTECHOVA, Eva SLONCOVA, Hynek STRNAD and Vladimir KORINEK (guarantor)

Edition

TRANSLATIONAL ONCOLOGY, New York, ELSEVIER SCIENCE INC, 2016, 1936-5233

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Full Text

Impact factor

Impact factor: 3.025

RIV identification code

RIV/00216224:14310/16:00111797

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1016/j.tranon.2016.01.005

UT WoS

000374979800002

Keywords in English

Apoptosis; Bnip3L; caspase-12; hair follicles; PCR arrays

Abstract

V originále

Neoplastic growth is frequently associated with genomic DNA methylation that causes transcriptional silencing of tumor suppressor genes. We used a collection of colorectal polyps and carcinomas in combination with bioinformatics analysis of large datasets to study the expression and methylation of Hypermethylated in cancer 1 (HIC1), a tumor suppressor gene inactivated in many neoplasms. In premalignant stages, HIC1 expression was decreased, and the decrease was linked to methylation of a specific region in the HIC1 locus. However, in carcinomas, the HIC1 expression was variable and, in some specimens, comparable to healthy tissue. Importantly, high HIC1 production distinguished a specific type of chemotherapy-responsive tumors.

Citovat

JANECKOVA, Lucie, Michal KOLAR, Jiri SVEC, Lucie LANIKOVA, Vendula POSPÍCHALOVÁ, Nikol BALOGHOVA, Martina VOJTECHOVA, Eva SLONCOVA, Hynek STRNAD and Vladimir KORINEK. HIC1 Expression Distinguishes Intestinal Carcinomas Sensitive to Chemotherapy. TRANSLATIONAL ONCOLOGY. New York: ELSEVIER SCIENCE INC, 2016, vol. 9, No 2, p. 99-107. ISSN 1936-5233. Available from: https://dx.doi.org/10.1016/j.tranon.2016.01.005.

@article{1594258,
   author = {Janeckova, Lucie and Kolar, Michal and Svec, Jiri and Lanikova, Lucie and Pospíchalová, Vendula and Baloghova, Nikol and Vojtechova, Martina and Sloncova, Eva and Strnad, Hynek and Korinek, Vladimir},
   article_location = {New York},
   article_number = {2},
   doi = {http://dx.doi.org/10.1016/j.tranon.2016.01.005},
   keywords = {Apoptosis; Bnip3L; caspase-12; hair follicles; PCR arrays},
   language = {eng},
   issn = {1936-5233},
   journal = {TRANSLATIONAL ONCOLOGY},
   title = {HIC1 Expression Distinguishes Intestinal Carcinomas Sensitive to Chemotherapy},
   url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833890/pdf/main.pdf},
   volume = {9},
   year = {2016}
}

TY  - JOUR
ID  - 1594258
AU  - Janeckova, Lucie - Kolar, Michal - Svec, Jiri - Lanikova, Lucie - Pospíchalová, Vendula - Baloghova, Nikol - Vojtechova, Martina - Sloncova, Eva - Strnad, Hynek - Korinek, Vladimir
PY  - 2016
TI  - HIC1 Expression Distinguishes Intestinal Carcinomas Sensitive to Chemotherapy
JF  - TRANSLATIONAL ONCOLOGY
VL  - 9
IS  - 2
SP  - 99-107
EP  - 99-107
PB  - ELSEVIER SCIENCE INC
SN  - 19365233
KW  - Apoptosis
KW  - Bnip3L
KW  - caspase-12
KW  - hair follicles
KW  - PCR arrays
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833890/pdf/main.pdf
L2  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833890/pdf/main.pdf
N2  - Neoplastic growth is frequently associated with genomic DNA methylation that causes transcriptional silencing of tumor suppressor genes. We used a collection of colorectal polyps and carcinomas in combination with bioinformatics analysis of large datasets to study the expression and methylation of Hypermethylated in cancer 1 (HIC1), a tumor suppressor gene inactivated in many neoplasms. In premalignant stages, HIC1 expression was decreased, and the decrease was linked to methylation of a specific region in the HIC1 locus. However, in carcinomas, the HIC1 expression was variable and, in some specimens, comparable to healthy tissue. Importantly, high HIC1 production distinguished a specific type of chemotherapy-responsive tumors.
ER  -

JANECKOVA, Lucie, Michal KOLAR, Jiri SVEC, Lucie LANIKOVA, Vendula POSPÍCHALOVÁ, Nikol BALOGHOVA, Martina VOJTECHOVA, Eva SLONCOVA, Hynek STRNAD and Vladimir KORINEK. HIC1 Expression Distinguishes Intestinal Carcinomas Sensitive to Chemotherapy. \textit{TRANSLATIONAL ONCOLOGY}. New York: ELSEVIER SCIENCE INC, 2016, vol.~9, No~2, p.~99-107. ISSN~1936-5233. Available from: https://dx.doi.org/10.1016/j.tranon.2016.01.005.

Detailed Information on Publication Record