KRÁL, Zdeněk, Jozef MICHALKA, Heidi MOCIKOVA, Jana MARKOVA, Alice SYKOROVA, David BELADA, Alexandra JUNGOVA, Samuel VOKURKA, Marie LUKASOVA, Vit PROCHAZKA, Juraj DURAS, Roman HAJEK, Ladislav DUŠEK, L'ubos DRGONA, Miriam LADICKA, Veronika BALLOVA and Andrei VRANOVSKY. Treatment of Relapsed/Refractory Hodgkin Lymphoma: Real-World Data from the Czech Republic and Slovakia. Journal of Cancer. Australia: IVYSPRING INT PUBL, 2019, vol. 10, No 21, p. 5041-5048. ISSN 1837-9664. Available from: https://dx.doi.org/10.7150/jca.29308. |
Other formats:
BibTeX
LaTeX
RIS
@article{1597497, author = {Král, Zdeněk and Michalka, Jozef and Mocikova, Heidi and Markova, Jana and Sykorova, Alice and Belada, David and Jungova, Alexandra and Vokurka, Samuel and Lukasova, Marie and Prochazka, Vit and Duras, Juraj and Hajek, Roman and Dušek, Ladislav and Drgona, L'ubos and Ladicka, Miriam and Ballova, Veronika and Vranovsky, Andrei}, article_location = {Australia}, article_number = {21}, doi = {http://dx.doi.org/10.7150/jca.29308}, keywords = {antibody-drug conjugate; CD30; brentuximab vedotin; Hodgkin lymphoma; registries; stem cell transplantation}, language = {eng}, issn = {1837-9664}, journal = {Journal of Cancer}, title = {Treatment of Relapsed/Refractory Hodgkin Lymphoma: Real-World Data from the Czech Republic and Slovakia}, url = {http://dx.doi.org/10.7150/jca.29308}, volume = {10}, year = {2019} }
TY - JOUR ID - 1597497 AU - Král, Zdeněk - Michalka, Jozef - Mocikova, Heidi - Markova, Jana - Sykorova, Alice - Belada, David - Jungova, Alexandra - Vokurka, Samuel - Lukasova, Marie - Prochazka, Vit - Duras, Juraj - Hajek, Roman - Dušek, Ladislav - Drgona, L'ubos - Ladicka, Miriam - Ballova, Veronika - Vranovsky, Andrei PY - 2019 TI - Treatment of Relapsed/Refractory Hodgkin Lymphoma: Real-World Data from the Czech Republic and Slovakia JF - Journal of Cancer VL - 10 IS - 21 SP - 5041-5048 EP - 5041-5048 PB - IVYSPRING INT PUBL SN - 18379664 KW - antibody-drug conjugate KW - CD30 KW - brentuximab vedotin KW - Hodgkin lymphoma KW - registries KW - stem cell transplantation UR - http://dx.doi.org/10.7150/jca.29308 L2 - http://dx.doi.org/10.7150/jca.29308 N2 - Introduction: Clinical trials have demonstrated the effectiveness of the CD30-targeted antibody- drug conjugate brentuximab vedotin (BV) for the treatment of relapsed/refractory Hodgkin lymphoma (R/R HL). In this study, we report on outcomes with BV in a real-world setting using data collected in clinics in the Czech Republic and Slovakia. Patients and Methods: Clinical and epidemiological data for patients with R/R HL who received treatment with BV at eight centers across the Czech Republic and Slovakia were examined. Data were amalgamated and analyzed retrospectively. Results: Clinical data for 58 patients (median age: 30.5 years) with R/R HL who received BV during the course of their treatment were collected and analyzed. Patients had received a median of 3 prior treatment regimens and most (91%) were treated with BV after relapse following autologous stem cell transplantation. Therapeutic responses after BV included 19 (33%) complete responses (CRs) and 8 (14%) partial responses. CRs occurred more frequently in patients who had received fewer prior treatment regimens. The 1-, 2-, and 3-year overall survival (OS) rates from initiation of BV were 78%, 62%, and 41%, respectively. Conclusion: Response rates and OS in this analysis of BV in real-world settings in the Czech Republic and Slovakia were consistent with those reported for pivotal clinical trials and from previous studies outside the clinical trial setting. The results support the efficacy of BV for treatment of R/R HL in real-life clinical practice. ER -
KRÁL, Zdeněk, Jozef MICHALKA, Heidi MOCIKOVA, Jana MARKOVA, Alice SYKOROVA, David BELADA, Alexandra JUNGOVA, Samuel VOKURKA, Marie LUKASOVA, Vit PROCHAZKA, Juraj DURAS, Roman HAJEK, Ladislav DUŠEK, L'ubos DRGONA, Miriam LADICKA, Veronika BALLOVA and Andrei VRANOVSKY. Treatment of Relapsed/Refractory Hodgkin Lymphoma: Real-World Data from the Czech Republic and Slovakia. \textit{Journal of Cancer}. Australia: IVYSPRING INT PUBL, 2019, vol.~10, No~21, p.~5041-5048. ISSN~1837-9664. Available from: https://dx.doi.org/10.7150/jca.29308.
|