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@article{1601606,
author = {Jarošová, Petra and Sándor, Roman and Slaninková, Andrea and Vido, Marek and Peš, Ondřej and Táborský, Petr},
article_location = {CHAM},
article_number = {12},
doi = {http://dx.doi.org/10.1007/s11696-019-00857-z},
keywords = {Protoberberine alkaloids; Non-canonical structures; G-quadruplex; dsDNA; Competitive dialysis; CD; Melting temperatures; Mass spectrometry},
language = {eng},
issn = {0366-6352},
journal = {Chemical Papers},
title = {Quaternary protoberberine alkaloids and their interactions with DNA},
url = {https://link.springer.com/article/10.1007%2Fs11696-019-00857-z},
volume = {73},
year = {2019}
}
TY - JOUR
ID - 1601606
AU - Jarošová, Petra - Sándor, Roman - Slaninková, Andrea - Vido, Marek - Peš, Ondřej - Táborský, Petr
PY - 2019
TI - Quaternary protoberberine alkaloids and their interactions with DNA
JF - Chemical Papers
VL - 73
IS - 12
SP - 2965-2973
EP - 2965-2973
PB - SPRINGER INTERNATIONAL PUBLISHING AG
SN - 03666352
KW - Protoberberine alkaloids
KW - Non-canonical structures
KW - G-quadruplex
KW - dsDNA
KW - Competitive dialysis
KW - CD
KW - Melting temperatures
KW - Mass spectrometry
UR - https://link.springer.com/article/10.1007%2Fs11696-019-00857-z
L2 - https://link.springer.com/article/10.1007%2Fs11696-019-00857-z
N2 - The G-quadruplex DNA is commonly present in several protooncogenic-DNA promoters and participates in many important biological processes such as replication, transcription, and translation. Because of their supposed role in cancer, G-quadruplex DNA is often studied as a target for anti-cancer drugs. Quaternary protoberberine and tetrahydroprotoberberine alkaloids (corysamine, coptisine, stylopine), which are supposed to selectively bind these structures, have been compared in terms of stability with selected types of DNA. Influence of selected alkaloids on the stability of double-stranded DNA and non-canonical forms of DNA was observed by determining association constants of alkaloid-DNA complexes using spectroscopic methods-molecular absorption spectrometry, fluorescence spectrometry, and mass spectrometry. Furthermore, the effect of given alkaloids on the melting temperature of these DNA structures was determined using CD spectrometry. Competitive dialysis and electrospray mass spectrometry were performed for affinity comparison of certain alkaloids to different DNA structures including G-quadruplexes. These experiments have proven that corysamine and coptisine prefer interaction with G-quadruplexes in comparison to dsDNA and ssDNA, whereas tetrahydroprotoberberine alkaloid stylopine does not interact with any DNA whatsoever.
ER -
JAROŠOVÁ, Petra, Roman SÁNDOR, Andrea SLANINKOVÁ, Marek VIDO, Ondřej PEŠ and Petr TÁBORSKÝ. Quaternary protoberberine alkaloids and their interactions with DNA. \textit{Chemical Papers}. CHAM: SPRINGER INTERNATIONAL PUBLISHING AG, 2019, vol.~73, No~12, p.~2965-2973. ISSN~0366-6352. Available from: https://dx.doi.org/10.1007/s11696-019-00857-z.
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