J 2019

Diffusion Tensor Imaging And Tractography In Autistic, Dysphasic, And Healthy Control Children

HRDLIČKA, Michal, Jan SANDA, Tomáš URBÁNEK, Martin KUDR, Iva DUDOVÁ et. al.

Basic information

Original name

Diffusion Tensor Imaging And Tractography In Autistic, Dysphasic, And Healthy Control Children

Authors

HRDLIČKA, Michal (203 Czech Republic, belonging to the institution), Jan SANDA, Tomáš URBÁNEK (203 Czech Republic, belonging to the institution), Martin KUDR, Iva DUDOVÁ, Štěpánka KICKOVÁ, Lenka POSPÍŠILOVÁ, Markéta MOHAPLOVÁ, Alice MAULISOVÁ, Pavel KRSEK, Martin KYNCL, Marek BLATNÝ (203 Czech Republic, guarantor, belonging to the institution) and Vladimír KOMAREK

Edition

Neuropsychiatric Disease and Treatment, New Zealand, Dove Medical Press, 2019, 1176-6328

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

50102 Psychology, special ;

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 2.154 in 2013

RIV identification code

RIV/00216224:14210/19:00112323

Organization unit

Faculty of Arts

DOI

UT WoS

000489159600002

Keywords in English

autism; developmental dysphasia; magnetic resonance imaging; diffusion tensor imaging; tractography

Tags

Změněno: 11/5/2020 21:29, Mgr. Zuzana Matulíková

Abstract

V originále

Background: Diffusion tensor imaging (DTI) is a powerful tool for investigating brain anatomical connectivity. The aim of our study was to compare brain connectivity among children with autism spectrum disorders (ASD), developmental dysphasia (DD), and healthy controls (HC) in the following tracts: the arcuate fasciculus (AF), inferior frontal occipital fasciculus (IFOF), inferior longitudinal fasciculus (ILF), and uncinate fasciculus (UF). Methods: Our sample consisted of 113 children with a mean age 8.7 +/- 2.2 years (77 boys, 36 girls), divided into three subgroups: ASD (n=39), DD (n=36), and HC (n=38). The International Classification of Diseases, 10th ed. was used to make clinical diagnoses. DTI images were collected using a 1.5 T Phillips Achieva MR imaging system. Results: Detailed analyses of fractional anisotropy (FA) revealed significant differences among the ASD, DD, and HC groups in the left AF (p=0.014) and right AF (p=0.001), the left IFOF (p<0.001) and right IFOF (p<0.001), the left ILF (p<0.001) and right ILF (p<0.001), but not in the UF. Post-hoc analyses revealed three patterns of FA differences among the groups: (1) in the right AF, right IFOF, and right ILF, FA was significantly lower in the ASD group compared to the DD and HC groups; however, there was no difference in FA between DD and HC; (2) in the left AF and left IFOF, FA was significantly lower in the ASD than in the HC group, but there were no differences between DD vs HC nor DD vs ASD; and (3) in the left ILF, no difference in FA was seen between ASD and DD, but FA in both was significantly lower than in the HC. Conclusion: Microstructural white matter properties differed between ASD vs DD and HC subjects. The tract where FA impairment in ASD and DD subjects was the most similar was the left ILF.