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@article{1603882,
author = {Grillová, Linda and Noda, Angel A. and Lienhard, Reto and Blanco, Orestes and Rodriguez, Islay and Šmajs, David},
article_location = {Chicago},
article_number = {7},
doi = {http://dx.doi.org/10.1093/infdis/jiy604},
keywords = {Treponema pallidum subsp. pallidum; multilocus sequence typing; macrolide resistance; recombination in treponemes; Cuba},
language = {eng},
issn = {0022-1899},
journal = {The Journal of Infectious Diseases},
title = {Multilocus Sequence Typing of Treponema pallidum subsp. pallidum in Cuba From 2012 to 2017},
url = {http://dx.doi.org/10.1093/infdis/jiy604},
volume = {219},
year = {2019}
}
TY - JOUR
ID - 1603882
AU - Grillová, Linda - Noda, Angel A. - Lienhard, Reto - Blanco, Orestes - Rodriguez, Islay - Šmajs, David
PY - 2019
TI - Multilocus Sequence Typing of Treponema pallidum subsp. pallidum in Cuba From 2012 to 2017
JF - The Journal of Infectious Diseases
VL - 219
IS - 7
SP - 1138-1145
EP - 1138-1145
PB - University of Chicago Press
SN - 00221899
KW - Treponema pallidum subsp. pallidum
KW - multilocus sequence typing
KW - macrolide resistance
KW - recombination in treponemes
KW - Cuba
UR - http://dx.doi.org/10.1093/infdis/jiy604
L2 - http://dx.doi.org/10.1093/infdis/jiy604
N2 - Background. The increased prevalence of syphilis in Cuba prompted us to map the circulating Treponema pallidum subsp. pallidum allelic profiles in this geographic region. Methods. Samples were collected from 2012 to 2017, from 83 male patients with ulcers or skin lesions, and were examined using multilocus sequence typing. Additionally, we analyzed the 23S rDNA and 16S rDNA regions for the presence of possible mutations leading to macrolide and tetracycline resistance. Results. Among 94% of fully typed strains, we found 7 different allelic profiles, of which 4 had not been previously described. More than 87% of patients were infected with the T. pallidum SS14-like group and only 8.2% with T. pallidum Nichols-like group. As in other countries, the 1.3.1 allelic profile (ie, SS14-like) was the most common. In addition, 1 of the newly described allelic profiles represents T. pallidum strains that arose by recombination events between members of different T. pallidum subgroups. More than 90% of patients were infected with treponemes harboring the A2058G mutation. However, we found no potential tetracycline-resistant T. pallidum mutations. Conclusions. Our results suggest that, in Cuba, tetracycline antibiotics could be used to treat syphilis in penicillin-allergic patients instead of macrolides.
ER -
GRILLOVÁ, Linda, Angel A. NODA, Reto LIENHARD, Orestes BLANCO, Islay RODRIGUEZ and David ŠMAJS. Multilocus Sequence Typing of Treponema pallidum subsp. pallidum in Cuba From 2012 to 2017. \textit{The Journal of Infectious Diseases}. Chicago: University of Chicago Press, 2019, vol.~219, No~7, p.~1138-1145. ISSN~0022-1899. Available from: https://dx.doi.org/10.1093/infdis/jiy604.
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