Detailed Information on Publication Record
2019
Multilocus Sequence Typing of Treponema pallidum subsp. pallidum in Cuba From 2012 to 2017
GRILLOVÁ, Linda, Angel A. NODA, Reto LIENHARD, Orestes BLANCO, Islay RODRIGUEZ et. al.Basic information
Original name
Multilocus Sequence Typing of Treponema pallidum subsp. pallidum in Cuba From 2012 to 2017
Authors
GRILLOVÁ, Linda (203 Czech Republic, belonging to the institution), Angel A. NODA (192 Cuba), Reto LIENHARD (756 Switzerland), Orestes BLANCO (192 Cuba), Islay RODRIGUEZ (192 Cuba) and David ŠMAJS (203 Czech Republic, belonging to the institution)
Edition
The Journal of Infectious Diseases, Chicago, University of Chicago Press, 2019, 0022-1899
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10606 Microbiology
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 5.022
RIV identification code
RIV/00216224:14110/19:00108019
Organization unit
Faculty of Medicine
UT WoS
000472805600016
Keywords in English
Treponema pallidum subsp. pallidum; multilocus sequence typing; macrolide resistance; recombination in treponemes; Cuba
Tags
International impact, Reviewed
Změněno: 4/3/2020 14:03, Mgr. Tereza Miškechová
Abstract
V originále
Background. The increased prevalence of syphilis in Cuba prompted us to map the circulating Treponema pallidum subsp. pallidum allelic profiles in this geographic region. Methods. Samples were collected from 2012 to 2017, from 83 male patients with ulcers or skin lesions, and were examined using multilocus sequence typing. Additionally, we analyzed the 23S rDNA and 16S rDNA regions for the presence of possible mutations leading to macrolide and tetracycline resistance. Results. Among 94% of fully typed strains, we found 7 different allelic profiles, of which 4 had not been previously described. More than 87% of patients were infected with the T. pallidum SS14-like group and only 8.2% with T. pallidum Nichols-like group. As in other countries, the 1.3.1 allelic profile (ie, SS14-like) was the most common. In addition, 1 of the newly described allelic profiles represents T. pallidum strains that arose by recombination events between members of different T. pallidum subgroups. More than 90% of patients were infected with treponemes harboring the A2058G mutation. However, we found no potential tetracycline-resistant T. pallidum mutations. Conclusions. Our results suggest that, in Cuba, tetracycline antibiotics could be used to treat syphilis in penicillin-allergic patients instead of macrolides.
Links
| GA17-25455S, research and development project |
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| MUNI/A/1087/2018, interní kód MU |
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| NV17-31333A, research and development project |
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