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@article{1603885, author = {Grillová, Linda and Jolley, Keith and Šmajs, David and Picardeau, Mathieu}, article_location = {London}, article_number = {JAN 9 2019}, doi = {http://dx.doi.org/10.7717/peerj.6182}, keywords = {Treponema pallidum subsp. pallidum; Molecular typing; PubMLST}, language = {eng}, issn = {2167-8359}, journal = {PeerJ}, title = {A public database for the new MLST scheme for Treponema pallidum subsp. pallidum: surveillance and epidemiology of the causative agent of syphilis}, url = {http://dx.doi.org/10.7717/peerj.6182}, volume = {6}, year = {2019} }
TY - JOUR ID - 1603885 AU - Grillová, Linda - Jolley, Keith - Šmajs, David - Picardeau, Mathieu PY - 2019 TI - A public database for the new MLST scheme for Treponema pallidum subsp. pallidum: surveillance and epidemiology of the causative agent of syphilis JF - PeerJ VL - 6 IS - JAN 9 2019 SP - 1-13 EP - 1-13 PB - PEERJ INC SN - 21678359 KW - Treponema pallidum subsp. pallidum KW - Molecular typing KW - PubMLST UR - http://dx.doi.org/10.7717/peerj.6182 L2 - http://dx.doi.org/10.7717/peerj.6182 N2 - Treponema pallidum subsp. pallidum is the causative agent of syphilis, a sexually transmitted disease with worldwide prevalence. Several different molecular typing schemes are currently available for this pathogen. To enable population biology studies of the syphilis agent and for epidemiological surveillance at the global scale, a harmonized typing tool needs to be introduced. Recently, we published a new multi-locus sequence typing (MLST) with the potential to significantly enhance the epidemiological data in several aspects (e.g., distinguishing genetically different clades of syphilis, subtyping inside these clades, and finally, distinguishing different subspecies of non-cultivable pathogenic treponemes). In this short report, we introduce the PubMLST database for treponemal DNA data storage and for assignments of allelic profiles and sequencing types. Moreover, we have summarized epidemiological data of all treponemal strains (n = 358) with available DNA sequences in typing loci and found several association between genetic groups and characteristics of patients. This study proposes the establishment of a single MLST of T. p. pallidum and encourages researchers and public health communities to use this PubMLST database as a universal tool for molecular typing studies of the syphilis pathogen. ER -
GRILLOVÁ, Linda, Keith JOLLEY, David ŠMAJS and Mathieu PICARDEAU. A public database for the new MLST scheme for Treponema pallidum subsp. pallidum: surveillance and epidemiology of the causative agent of syphilis. \textit{PeerJ}. London: PEERJ INC, 2019, vol.~6, JAN 9 2019, p.~1-13. ISSN~2167-8359. Available from: https://dx.doi.org/10.7717/peerj.6182.
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