Detailed Information on Publication Record
2019
Freshwater Cyanotoxin Cylindrospermopsin Has Detrimental Stage-specific Effects on Hepatic Differentiation From Human Embryonic Stem Cells
VÁŇOVÁ, Tereza, Jan RAŠKA, Pavel BABICA, Iva SOVADINOVÁ, Michaela BOSÁKOVÁ et. al.Basic information
Original name
Freshwater Cyanotoxin Cylindrospermopsin Has Detrimental Stage-specific Effects on Hepatic Differentiation From Human Embryonic Stem Cells
Authors
VÁŇOVÁ, Tereza (203 Czech Republic, belonging to the institution), Jan RAŠKA (203 Czech Republic, belonging to the institution), Pavel BABICA (203 Czech Republic, belonging to the institution), Iva SOVADINOVÁ (203 Czech Republic, belonging to the institution), Michaela BOSÁKOVÁ (203 Czech Republic, belonging to the institution), Petr DVOŘÁK (203 Czech Republic, belonging to the institution), Luděk BLÁHA (203 Czech Republic, belonging to the institution) and Vladimír ROTREKL (203 Czech Republic, guarantor, belonging to the institution)
Edition
Toxicological sciences, OXFORD, Academic Press, 2019, 1096-6080
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30108 Toxicology
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 3.703
RIV identification code
RIV/00216224:14110/19:00108022
Organization unit
Faculty of Medicine
UT WoS
000462865100021
Keywords in English
cylindrospermopsin; hepatic differentiation; human embryonic stem cells; liver; cyanotoxin
Tags
International impact, Reviewed
Změněno: 4/3/2020 14:06, Mgr. Tereza Miškechová
Abstract
V originále
Cylindrospermopsin (CYN) has been recognized as a potent waterborne hepatotoxin with an increasing environmental occurrence. However, CYN effects on the specific populations of hepatic cells involved in liver tissue development, renewal, and regeneration, have not been characterized yet. We used human embryonic stem cells to analyze the hepatic differentiation stage-specific effect of CYN. Our results strongly suggest that CYN might contribute to the development of chronic adverse outcomes by disrupting liver tissue homeostasis in terms of (1) cellular stress and damage induced in the mature differentiated hepatocytes, which was associated with a necrotic cell death and thus possibly also inflammatory responses; (2) selective elimination of HNF4+ cells from populations of progenitor cells and immature hepatocytes during hepatic differentiation, which could possibly lead to an impaired liver renewal and regeneration; (3) impaired hepatic functions of immature hepatocytes, such as decreased albumin secretion or increased lipid accumulation, which could contribute to the development of liver steatosis; and (4) survival of the immature and AFP-expressing cells with the limited ability to further differentiate, which could represent a tumor-promoting condition.
Links
EF16_013/0001761, research and development project |
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GA15-12408S, research and development project |
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GA15-23033S, research and development project |
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GBP302/12/G157, research and development project |
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LM2015051, research and development project |
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LQ1601, research and development project |
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MUNI/A/1087/2018, interní kód MU |
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