Strain diversity of Treponema pallidum subsp. pertenue suggests
rare interspecies transmission in African nonhuman primates

J 2019

Strain diversity of Treponema pallidum subsp. pertenue suggests rare interspecies transmission in African nonhuman primates

CHUMA, Idrissa S., Christian ROOS, Anagaw ATICKEM, Torsten BOHM, D. Anthony COLLINS et. al.

Basic information

Original name

Strain diversity of Treponema pallidum subsp. pertenue suggests rare interspecies transmission in African nonhuman primates

Authors

CHUMA, Idrissa S. (276 Germany), Christian ROOS (276 Germany), Anagaw ATICKEM (231 Ethiopia), Torsten BOHM (178 Congo), D. Anthony COLLINS (834 Tanzania, United Republic of), Linda GRILLOVÁ (203 Czech Republic, belonging to the institution), Luisa K. HALLMAIER-WACKER (276 Germany), Rudovick R. KAZWALA (834 Tanzania, United Republic of), Julius D. KEYYU (834 Tanzania, United Republic of), Simone LUERT (276 Germany), Ulrich MALOUEKI (178 Congo), Jan OPPELT (203 Czech Republic, belonging to the institution), Klara J. PETRZELKOVA (203 Czech Republic), Alexander PIEL (826 United Kingdom of Great Britain and Northern Ireland), Fiona A. STEWART (826 United Kingdom of Great Britain and Northern Ireland), David ŠMAJS (203 Czech Republic, belonging to the institution) and Sascha KNAUF (276 Germany, guarantor)

Edition

Scientific reports, LONDON, NATURE PUBLISHING GROUP, 2019, 2045-2322

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10608 Biochemistry and molecular biology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.998

RIV identification code

RIV/00216224:14110/19:00108042

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1038/s41598-019-50779-9

UT WoS

000488482200025

Keywords in English

RIBOSOMAL-RNA GENE; MACROLIDE RESISTANCE; INFECTION; MUTATION; TREE

Abstract

V originále

In our most recent study, we found that in Tanzania infection with Treponema pallidum (TP) subsp. pertenue (TPE) is present in four different monkey species. In order to gain information on the diversity and epidemiological spread of the infection in Tanzanian nonhuman primates (NHP), we identified two suitable candidate genes for multi-locus sequence typing (MLST). We demonstrate the functionality of the MLST system in invasively and non-invasively collected samples. While we were not able to demonstrate frequent interspecies transmission of TPE in Tanzanian monkeys, our results show a clustering of TPE strains according to geography and not host species, which is suggestive for rare transmission events between different NHP species. In addition to the geographic stability, we describe the relative temporal stability of the strains infecting NHPs and identified multi-strain infection. Differences between TPE strains of NHP and human origin are highlighted. Our results show that antibiotic resistance does not occur in Tanzanian TPE strains of NHP origin.

Links

GA17-25455S, research and development project

Name: Studium genomů patogenních treponem na základě analýzy jednotlivých buněk

Investor: Czech Science Foundation

GC18-23521J, research and development project

Name: Treponematózy u zástupců řádu zajícovci: genetická diverzita treponem a příbuznost s lidským patogenem T. pallidum

Investor: Czech Science Foundation

MUNI/A/1087/2018, interní kód MU

Name: Molekulární a buněčná biologie pro biomedicínské vědy

Investor: Masaryk University, Category A

90091, large research infrastructures

Name: NCMG

Citovat

CHUMA, Idrissa S., Christian ROOS, Anagaw ATICKEM, Torsten BOHM, D. Anthony COLLINS, Linda GRILLOVÁ, Luisa K. HALLMAIER-WACKER, Rudovick R. KAZWALA, Julius D. KEYYU, Simone LUERT, Ulrich MALOUEKI, Jan OPPELT, Klara J. PETRZELKOVA, Alexander PIEL, Fiona A. STEWART, David ŠMAJS and Sascha KNAUF. Strain diversity of Treponema pallidum subsp. pertenue suggests rare interspecies transmission in African nonhuman primates. Scientific reports. LONDON: NATURE PUBLISHING GROUP, 2019, vol. 9, OCT 2 2019, p. 1-9. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/s41598-019-50779-9.

@article{1604496,
   author = {Chuma, Idrissa S. and Roos, Christian and Atickem, Anagaw and Bohm, Torsten and Collins, D. Anthony and Grillová, Linda and HallmaierandWacker, Luisa K. and Kazwala, Rudovick R. and Keyyu, Julius D. and Luert, Simone and Maloueki, Ulrich and Oppelt, Jan and Petrzelkova, Klara J. and Piel, Alexander and Stewart, Fiona A. and Šmajs, David and Knauf, Sascha},
   article_location = {LONDON},
   article_number = {OCT 2 2019},
   doi = {http://dx.doi.org/10.1038/s41598-019-50779-9},
   keywords = {RIBOSOMAL-RNA GENE; MACROLIDE RESISTANCE; INFECTION; MUTATION; TREE},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific reports},
   title = {Strain diversity of Treponema pallidum subsp. pertenue suggests rare interspecies transmission in African nonhuman primates},
   url = {https://www.nature.com/articles/s41598-019-50779-9.pdf},
   volume = {9},
   year = {2019}
}

TY  - JOUR
ID  - 1604496
AU  - Chuma, Idrissa S. - Roos, Christian - Atickem, Anagaw - Bohm, Torsten - Collins, D. Anthony - Grillová, Linda - Hallmaier-Wacker, Luisa K. - Kazwala, Rudovick R. - Keyyu, Julius D. - Luert, Simone - Maloueki, Ulrich - Oppelt, Jan - Petrzelkova, Klara J. - Piel, Alexander - Stewart, Fiona A. - Šmajs, David - Knauf, Sascha
PY  - 2019
TI  - Strain diversity of Treponema pallidum subsp. pertenue suggests rare interspecies transmission in African nonhuman primates
JF  - Scientific reports
VL  - 9
IS  - OCT 2 2019
SP  - 1-9
EP  - 1-9
PB  - NATURE PUBLISHING GROUP
SN  - 20452322
KW  - RIBOSOMAL-RNA GENE
KW  - MACROLIDE RESISTANCE
KW  - INFECTION
KW  - MUTATION
KW  - TREE
UR  - https://www.nature.com/articles/s41598-019-50779-9.pdf
L2  - https://www.nature.com/articles/s41598-019-50779-9.pdf
N2  - In our most recent study, we found that in Tanzania infection with Treponema pallidum (TP) subsp. pertenue (TPE) is present in four different monkey species. In order to gain information on the diversity and epidemiological spread of the infection in Tanzanian nonhuman primates (NHP), we identified two suitable candidate genes for multi-locus sequence typing (MLST). We demonstrate the functionality of the MLST system in invasively and non-invasively collected samples. While we were not able to demonstrate frequent interspecies transmission of TPE in Tanzanian monkeys, our results show a clustering of TPE strains according to geography and not host species, which is suggestive for rare transmission events between different NHP species. In addition to the geographic stability, we describe the relative temporal stability of the strains infecting NHPs and identified multi-strain infection. Differences between TPE strains of NHP and human origin are highlighted. Our results show that antibiotic resistance does not occur in Tanzanian TPE strains of NHP origin.
ER  -

CHUMA, Idrissa S., Christian ROOS, Anagaw ATICKEM, Torsten BOHM, D. Anthony COLLINS, Linda GRILLOVÁ, Luisa K. HALLMAIER-WACKER, Rudovick R. KAZWALA, Julius D. KEYYU, Simone LUERT, Ulrich MALOUEKI, Jan OPPELT, Klara J. PETRZELKOVA, Alexander PIEL, Fiona A. STEWART, David ŠMAJS and Sascha KNAUF. Strain diversity of Treponema pallidum subsp. pertenue suggests rare interspecies transmission in African nonhuman primates. \textit{Scientific reports}. LONDON: NATURE PUBLISHING GROUP, 2019, vol.~9, OCT 2 2019, p.~1-9. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-019-50779-9.

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