| CHUMA, Idrissa S., Christian ROOS, Anagaw ATICKEM, Torsten BOHM, D. Anthony COLLINS, Linda GRILLOVÁ, Luisa K. HALLMAIER-WACKER, Rudovick R. KAZWALA, Julius D. KEYYU, Simone LUERT, Ulrich MALOUEKI, Jan OPPELT, Klara J. PETRZELKOVA, Alexander PIEL, Fiona A. STEWART, David ŠMAJS and Sascha KNAUF. Strain diversity of Treponema pallidum subsp. pertenue suggests rare interspecies transmission in African nonhuman primates. Scientific reports. LONDON: NATURE PUBLISHING GROUP, 2019, vol. 9, OCT 2 2019, p. 1-9. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/s41598-019-50779-9. |
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@article{1604496,
author = {Chuma, Idrissa S. and Roos, Christian and Atickem, Anagaw and Bohm, Torsten and Collins, D. Anthony and Grillová, Linda and HallmaierandWacker, Luisa K. and Kazwala, Rudovick R. and Keyyu, Julius D. and Luert, Simone and Maloueki, Ulrich and Oppelt, Jan and Petrzelkova, Klara J. and Piel, Alexander and Stewart, Fiona A. and Šmajs, David and Knauf, Sascha},
article_location = {LONDON},
article_number = {OCT 2 2019},
doi = {http://dx.doi.org/10.1038/s41598-019-50779-9},
keywords = {RIBOSOMAL-RNA GENE; MACROLIDE RESISTANCE; INFECTION; MUTATION; TREE},
language = {eng},
issn = {2045-2322},
journal = {Scientific reports},
title = {Strain diversity of Treponema pallidum subsp. pertenue suggests rare interspecies transmission in African nonhuman primates},
url = {https://www.nature.com/articles/s41598-019-50779-9.pdf},
volume = {9},
year = {2019}
}
TY - JOUR
ID - 1604496
AU - Chuma, Idrissa S. - Roos, Christian - Atickem, Anagaw - Bohm, Torsten - Collins, D. Anthony - Grillová, Linda - Hallmaier-Wacker, Luisa K. - Kazwala, Rudovick R. - Keyyu, Julius D. - Luert, Simone - Maloueki, Ulrich - Oppelt, Jan - Petrzelkova, Klara J. - Piel, Alexander - Stewart, Fiona A. - Šmajs, David - Knauf, Sascha
PY - 2019
TI - Strain diversity of Treponema pallidum subsp. pertenue suggests rare interspecies transmission in African nonhuman primates
JF - Scientific reports
VL - 9
IS - OCT 2 2019
SP - 1-9
EP - 1-9
PB - NATURE PUBLISHING GROUP
SN - 20452322
KW - RIBOSOMAL-RNA GENE
KW - MACROLIDE RESISTANCE
KW - INFECTION
KW - MUTATION
KW - TREE
UR - https://www.nature.com/articles/s41598-019-50779-9.pdf
L2 - https://www.nature.com/articles/s41598-019-50779-9.pdf
N2 - In our most recent study, we found that in Tanzania infection with Treponema pallidum (TP) subsp. pertenue (TPE) is present in four different monkey species. In order to gain information on the diversity and epidemiological spread of the infection in Tanzanian nonhuman primates (NHP), we identified two suitable candidate genes for multi-locus sequence typing (MLST). We demonstrate the functionality of the MLST system in invasively and non-invasively collected samples. While we were not able to demonstrate frequent interspecies transmission of TPE in Tanzanian monkeys, our results show a clustering of TPE strains according to geography and not host species, which is suggestive for rare transmission events between different NHP species. In addition to the geographic stability, we describe the relative temporal stability of the strains infecting NHPs and identified multi-strain infection. Differences between TPE strains of NHP and human origin are highlighted. Our results show that antibiotic resistance does not occur in Tanzanian TPE strains of NHP origin.
ER -
CHUMA, Idrissa S., Christian ROOS, Anagaw ATICKEM, Torsten BOHM, D. Anthony COLLINS, Linda GRILLOVÁ, Luisa K. HALLMAIER-WACKER, Rudovick R. KAZWALA, Julius D. KEYYU, Simone LUERT, Ulrich MALOUEKI, Jan OPPELT, Klara J. PETRZELKOVA, Alexander PIEL, Fiona A. STEWART, David ŠMAJS and Sascha KNAUF. Strain diversity of Treponema pallidum subsp. pertenue suggests rare interspecies transmission in African nonhuman primates. \textit{Scientific reports}. LONDON: NATURE PUBLISHING GROUP, 2019, vol.~9, OCT 2 2019, p.~1-9. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-019-50779-9.
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