The use of micro carbon pencil lead electrode for sensitive
HPLC-ED analysis of selected antipsychotic drugs

J 2020

The use of micro carbon pencil lead electrode for sensitive HPLC-ED analysis of selected antipsychotic drugs

RIMAN, Daniel, Jan ROZSYPAL, Vladimír HALOUZKA, Jan HRBÁČ, David JIROVSKÝ et. al.

Basic information

Original name

The use of micro carbon pencil lead electrode for sensitive HPLC-ED analysis of selected antipsychotic drugs

Authors

RIMAN, Daniel (203 Czech Republic), Jan ROZSYPAL (203 Czech Republic), Vladimír HALOUZKA (203 Czech Republic), Jan HRBÁČ (203 Czech Republic, belonging to the institution) and David JIROVSKÝ (203 Czech Republic, guarantor)

Edition

Microchemical Journal, Amsterdam, Elsevier, 2020, 0026-265X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10405 Electrochemistry

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.821

RIV identification code

RIV/00216224:14310/20:00115198

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1016/j.microc.2020.104606

UT WoS

000527366200077

Keywords in English

HPLC; Antipsychotics; Electrochemical detection; Voltammetry; Pencil electrode

Abstract

V originále

Sensitive analysis of nine selected antipsychotic drugs is demonstrated by high performance liquid chromatography coupled with innovative electrochemical detector employing the non standard, 0.2 mm diameter Pentel AinStein pencil graphite as a working electrode. In addition to low cost, the detector performance is characterized by low background current, capability to operate in low ionic strength media and very fast attainment of stable baseline. These advantageous features are attributed to microelectrode character of the pencil lead surface. The concentration LODs ranged between 1.0 (olanzapine) and 7.9 nmol/L (chlorpromazine) with linearity up to 500 nmol/L . Model analyses in spiked control serum as well as the real sample analyses of human plasma samples of subjects after intoxication with olanzapine resp. promethazine are shown. According to relevant assessment tools, the whole procedure can be regarded as green.

Links

MUNI/A/1359/2018, interní kód MU

Name: Vývoj metod a instrumentace pro analýzu biologicky významných látek 2019

Investor: Masaryk University, Category A

Citovat

RIMAN, Daniel, Jan ROZSYPAL, Vladimír HALOUZKA, Jan HRBÁČ and David JIROVSKÝ. The use of micro carbon pencil lead electrode for sensitive HPLC-ED analysis of selected antipsychotic drugs. Microchemical Journal. Amsterdam: Elsevier, 2020, vol. 154, May 2020, p. 1-8. ISSN 0026-265X. Available from: https://dx.doi.org/10.1016/j.microc.2020.104606.

@article{1604497,
   author = {Riman, Daniel and Rozsypal, Jan and Halouzka, Vladimír and Hrbáč, Jan and Jirovský, David},
   article_location = {Amsterdam},
   article_number = {May 2020},
   doi = {http://dx.doi.org/10.1016/j.microc.2020.104606},
   keywords = {HPLC; Antipsychotics; Electrochemical detection; Voltammetry; Pencil electrode},
   language = {eng},
   issn = {0026-265X},
   journal = {Microchemical Journal},
   title = {The use of micro carbon pencil lead electrode for sensitive HPLC-ED analysis of selected antipsychotic drugs},
   url = {https://www.sciencedirect.com/science/article/pii/S0026265X19330991?via%3Dihub},
   volume = {154},
   year = {2020}
}

TY  - JOUR
ID  - 1604497
AU  - Riman, Daniel - Rozsypal, Jan - Halouzka, Vladimír - Hrbáč, Jan - Jirovský, David
PY  - 2020
TI  - The use of micro carbon pencil lead electrode for sensitive HPLC-ED analysis of selected antipsychotic drugs
JF  - Microchemical Journal
VL  - 154
IS  - May 2020
SP  - 1-8
EP  - 1-8
PB  - Elsevier
SN  - 0026265X
KW  - HPLC
KW  - Antipsychotics
KW  - Electrochemical detection
KW  - Voltammetry
KW  - Pencil electrode
UR  - https://www.sciencedirect.com/science/article/pii/S0026265X19330991?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/pii/S0026265X19330991?via%3Dihub
N2  - Sensitive analysis of nine selected antipsychotic drugs is demonstrated by high performance liquid chromatography coupled with innovative electrochemical detector employing the non standard, 0.2 mm diameter Pentel AinStein pencil graphite as a working electrode. In addition to low cost, the detector performance is characterized by low background current, capability to operate in low ionic strength media and very fast attainment of stable baseline. These advantageous features are attributed to microelectrode character of the pencil lead surface. The concentration LODs ranged between 1.0 (olanzapine) and 7.9 nmol/L (chlorpromazine) with linearity up to 500 nmol/L . Model analyses in spiked control serum as well as the real sample analyses of human plasma samples of subjects after intoxication with olanzapine resp. promethazine are shown. According to relevant assessment tools, the whole procedure can be regarded as green.
ER  -

RIMAN, Daniel, Jan ROZSYPAL, Vladimír HALOUZKA, Jan HRBÁČ and David JIROVSKÝ. The use of micro carbon pencil lead electrode for sensitive HPLC-ED analysis of selected antipsychotic drugs. \textit{Microchemical Journal}. Amsterdam: Elsevier, 2020, vol.~154, May 2020, p.~1-8. ISSN~0026-265X. Available from: https://dx.doi.org/10.1016/j.microc.2020.104606.

Detailed Information on Publication Record