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@article{1604544,
author = {Machala, Miroslav and Prochazkova, Jirina and Hofmanova, Jirina and Kralikova, Lucie and Slavik, Josef and Tylichova, Zuzana and Ovesná, Petra and Kozubik, Alois and Vondracek, Jan},
article_location = {Basel},
article_number = {23},
doi = {http://dx.doi.org/10.3390/ijms20236051},
keywords = {colorectal cancer; colon cancer cells; sphingolipid; glycosphingolipid; colon cancer (CRC) sphingolipidomics; sphingosine-1-phosphate; lactosylceramide},
language = {eng},
issn = {1422-0067},
journal = {International Journal of Molecular Sciences},
title = {Colon Cancer and Perturbations of the Sphingolipid Metabolism},
url = {http://dx.doi.org/10.3390/ijms20236051},
volume = {20},
year = {2019}
}
TY - JOUR
ID - 1604544
AU - Machala, Miroslav - Prochazkova, Jirina - Hofmanova, Jirina - Kralikova, Lucie - Slavik, Josef - Tylichova, Zuzana - Ovesná, Petra - Kozubik, Alois - Vondracek, Jan
PY - 2019
TI - Colon Cancer and Perturbations of the Sphingolipid Metabolism
JF - International Journal of Molecular Sciences
VL - 20
IS - 23
SP - 1-14
EP - 1-14
PB - Multidisciplinary Digital Publishing Institute
SN - 14220067
KW - colorectal cancer
KW - colon cancer cells
KW - sphingolipid
KW - glycosphingolipid
KW - colon cancer (CRC) sphingolipidomics
KW - sphingosine-1-phosphate
KW - lactosylceramide
UR - http://dx.doi.org/10.3390/ijms20236051
L2 - http://dx.doi.org/10.3390/ijms20236051
N2 - The development and progression of colorectal cancer (CRC), a major cause of cancer-related death in the western world, is accompanied with alterations of sphingolipid (SL) composition in colon tumors. A number of enzymes involved in the SL metabolism have been found to be deregulated in human colon tumors, in experimental rodent studies, and in human colon cancer cells in vitro. Therefore, the enzymatic pathways that modulate SL levels have received a significant attention, due to their possible contribution to CRC development, or as potential therapeutic targets. Many of these enzymes are associated with an increased sphingosine-1-phosphate/ceramide ratio, which is in turn linked with increased colon cancer cell survival, proliferation and cancer progression. Nevertheless, more attention should also be paid to the more complex SLs, including specific glycosphingolipids, such as lactosylceramides, which can be also deregulated during CRC development. In this review, we focus on the potential roles of individual SLs/SL metabolism enzymes in colon cancer, as well as on the pros and cons of employing the current in vitro models of colon cancer cells for lipidomic studies investigating the SL metabolism in CRC.
ER -
MACHALA, Miroslav, Jirina PROCHAZKOVA, Jirina HOFMANOVA, Lucie KRALIKOVA, Josef SLAVIK, Zuzana TYLICHOVA, Petra OVESNÁ, Alois KOZUBIK and Jan VONDRACEK. Colon Cancer and Perturbations of the Sphingolipid Metabolism. \textit{International Journal of Molecular Sciences}. Basel: Multidisciplinary Digital Publishing Institute, 2019, vol.~20, No~23, p.~1-14. ISSN~1422-0067. Available from: https://dx.doi.org/10.3390/ijms20236051.
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