J 2019

Sex differences in heart rate responses to postural provocations

HNATKOVA, Katarina, Martina ŠIŠÁKOVÁ, Peter SMETANA, Ondřej TOMAN, Katharina M. HUSTER et. al.

Basic information

Original name

Sex differences in heart rate responses to postural provocations

Authors

HNATKOVA, Katarina (826 United Kingdom of Great Britain and Northern Ireland), Martina ŠIŠÁKOVÁ (203 Czech Republic, belonging to the institution), Peter SMETANA (40 Austria), Ondřej TOMAN (203 Czech Republic, belonging to the institution), Katharina M. HUSTER (276 Germany), Tomáš NOVOTNÝ (203 Czech Republic, belonging to the institution), Georg SCHMIDT (276 Germany) and Marek MALIK (826 United Kingdom of Great Britain and Northern Ireland, guarantor)

Edition

International Journal of Cardiology, Clare, Elsevier Ireland Ltd. 2019, 0167-5273

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 3.229

RIV identification code

RIV/00216224:14110/19:00112433

Organization unit

Faculty of Medicine

DOI

UT WoS

000502550800030

Keywords in English

Sex differences; Postural changes; Heart rate; Heart rate variability; Autonomic modulations; Autonomic responsiveness; Responses to stress

Tags

Tags

International impact, Reviewed
Změněno: 16/1/2020 08:06, Mgr. Tereza Miškechová

Abstract

V originále

Sex differences are known in several facets of cardiac electrophysiology, mostly concerning myocardial repolarisation. In this study, heart rate and heart rate variability (HRV) responses to postural provocations were compared in 175 and 176 healthy females and males, respectively (aged 33.1 +/- 9.1 years). Two different postural provocative tests with position changes supine -> sitting -> standing -> supine and supine -> standing -> sitting -> supine (15-min standing, 10-min other positions) were performed up to 4 times in each subject. Heart rate and heart rate variability spectral indices were measured in 5-min windows before positional changes. At supine position, females had averaged heart rate approximately 5 beats per minute (bpm) faster than males and this sex difference was practically constant during the postural changes. In both sexes, change supine -> sitting and supine -> standing increased heart rate by approximately 10 and 30 bpm, respectively, with no statistical differences between the sex groups. At supine baseline, females had normalised high frequency components (nHF) of HRV approximately 7% larger compared to males (p < 0.001). While the same difference in nHF was found at sitting, the change to standing position lead to significantly larger nHF reduction in females compared to males (mean changes 22.5 vs 17.2%, p < 0.001). This shows that despite similar heart rate increase, females respond to standing by more substantial shifts in cardiac sympatho- vagal modulations. This makes it plausible to speculate that the differences in autonomic reactions to stress contribute to the known sex-differences in psychosocial responses to stressful situations and to the known difference in susceptibility to ventricular fibrillation between females and males. (C) 2019 The Authors. Published by Elsevier B.V.