LAUSEKER, Michael, Katharina BACHL, Anna TURKINA, Edgar FABER, Witold PREJZNER, Ulla OLSSON-STROMBERG,, Michele BACCARANI, Elza LOMAIA, Daniela ŽÁČKOVÁ, Gert OSSENKOPPELE, Laimonas GRISKEVICIUS, Gabriele SCHUBERT-FRITSCHLE, Tomasz SACHA, Sonja HEIBL, Perttu KOSKENVESA, Andrija BOGDANOVIC, Richard E. CLARK, Joelle GUILHOT, Verena S. HOFFMANN, Joerg HASFORD, Andreas HOCHHAUS and Markus PFIRRMANN. Prognosis of patients with chronic myeloid leukemia presenting in advanced phase is defined mainly by blast count, but also by age, chromosomal aberrations and hemoglobin. American Journal of Hematology. Hoboken: John Wiley & Sons, 2019, vol. 94, No 11, p. 1236-1243. ISSN 0361-8609. Available from: https://dx.doi.org/10.1002/ajh.25628. |
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@article{1605421, author = {Lauseker, Michael and Bachl, Katharina and Turkina, Anna and Faber, Edgar and Prejzner, Witold and OlssonandStromberg,, Ulla and Baccarani, Michele and Lomaia, Elza and Žáčková, Daniela and Ossenkoppele, Gert and Griskevicius, Laimonas and SchubertandFritschle, Gabriele and Sacha, Tomasz and Heibl, Sonja and Koskenvesa, Perttu and Bogdanovic, Andrija and Clark, Richard E. and Guilhot, Joelle and Hoffmann, Verena S. and Hasford, Joerg and Hochhaus, Andreas and Pfirrmann, Markus}, article_location = {Hoboken}, article_number = {11}, doi = {http://dx.doi.org/10.1002/ajh.25628}, keywords = {WORLD-HEALTH-ORGANIZATION; CHRONIC MYELOGENOUS LEUKEMIA; TYROSINE KINASE INHIBITORS; 2904 CML PATIENTS; RANDOMIZED CML; SURVIVAL; MANAGEMENT; IMATINIB; ERA; RECOMMENDATIONS}, language = {eng}, issn = {0361-8609}, journal = {American Journal of Hematology}, title = {Prognosis of patients with chronic myeloid leukemia presenting in advanced phase is defined mainly by blast count, but also by age, chromosomal aberrations and hemoglobin}, url = {http://dx.doi.org/10.1002/ajh.25628}, volume = {94}, year = {2019} }
TY - JOUR ID - 1605421 AU - Lauseker, Michael - Bachl, Katharina - Turkina, Anna - Faber, Edgar - Prejzner, Witold - Olsson-Stromberg,, Ulla - Baccarani, Michele - Lomaia, Elza - Žáčková, Daniela - Ossenkoppele, Gert - Griskevicius, Laimonas - Schubert-Fritschle, Gabriele - Sacha, Tomasz - Heibl, Sonja - Koskenvesa, Perttu - Bogdanovic, Andrija - Clark, Richard E. - Guilhot, Joelle - Hoffmann, Verena S. - Hasford, Joerg - Hochhaus, Andreas - Pfirrmann, Markus PY - 2019 TI - Prognosis of patients with chronic myeloid leukemia presenting in advanced phase is defined mainly by blast count, but also by age, chromosomal aberrations and hemoglobin JF - American Journal of Hematology VL - 94 IS - 11 SP - 1236-1243 EP - 1236-1243 PB - John Wiley & Sons SN - 03618609 KW - WORLD-HEALTH-ORGANIZATION KW - CHRONIC MYELOGENOUS LEUKEMIA KW - TYROSINE KINASE INHIBITORS KW - 2904 CML PATIENTS KW - RANDOMIZED CML KW - SURVIVAL KW - MANAGEMENT KW - IMATINIB KW - ERA KW - RECOMMENDATIONS UR - http://dx.doi.org/10.1002/ajh.25628 L2 - http://dx.doi.org/10.1002/ajh.25628 N2 - Chronic myeloid leukemia (CML) is usually diagnosed in chronic phase, yet there is a small percentage of patients that is diagnosed in accelerated phase or blast crisis. Due to this rarity, little is known about the prognosis of these patients. Our aim was to identify prognostic factors for this cohort. We identified 283 patients in the EUTOS population-based and out-study registries that were diagnosed in advanced phase. Nearly all patients were treated with tyrosine kinase inhibitors. Median survival in this heterogeneous cohort was 8.2 years. When comparing patients with more than 30% blasts to those with 20-29% blasts, the hazard ratio (HR) was 1.32 (95%-confidence interval (CI): [0.7-2.6]). Patients with 20-29% blasts had a significantly higher risk than patients with less than 20% blasts (HR: 2.24, 95%-CI: [1.2-4.0], P = .008). We found that the blast count was the most important prognostic factor; however, age, hemoglobin, basophils and other chromosomal aberrations should be considered as well. The ELTS score was able to define two groups (high risk vs non-high risk) with an HR of 3.01 (95%-CI: [1.81-5.00], P < .001). Regarding the contrasting definitions of blast crisis, our data clearly supported the 20% cut-off over the 30% cut-off in this cohort. Based on our results, we conclude that a one-phase rather than a two-phase categorization of de novo advanced phase CML patients is appropriate. ER -
LAUSEKER, Michael, Katharina BACHL, Anna TURKINA, Edgar FABER, Witold PREJZNER, Ulla OLSSON-STROMBERG,, Michele BACCARANI, Elza LOMAIA, Daniela ŽÁČKOVÁ, Gert OSSENKOPPELE, Laimonas GRISKEVICIUS, Gabriele SCHUBERT-FRITSCHLE, Tomasz SACHA, Sonja HEIBL, Perttu KOSKENVESA, Andrija BOGDANOVIC, Richard E. CLARK, Joelle GUILHOT, Verena S. HOFFMANN, Joerg HASFORD, Andreas HOCHHAUS and Markus PFIRRMANN. Prognosis of patients with chronic myeloid leukemia presenting in advanced phase is defined mainly by blast count, but also by age, chromosomal aberrations and hemoglobin. \textit{American Journal of Hematology}. Hoboken: John Wiley \&{} Sons, 2019, vol.~94, No~11, p.~1236-1243. ISSN~0361-8609. Available from: https://dx.doi.org/10.1002/ajh.25628.
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