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@article{1605485, author = {EstebanandGil, Angel and PerezandSanz, Fernando and GarciaandSolano, Jose and AlburquerqueandGonzalez, Begona and ParrenoandGonzalez, Maria and LegazandGarcia, Maria del Carmen and FernandezandBreis, Jesualdo Tomas and RodriguezandBraun, Edith and Pimentel, Paola and Tuomisto, Anne and Makinen, Markus and Slabý, Ondřej and ConesaandZamora, Pablo}, article_location = {LONDON}, article_number = {OCT 31 2019}, doi = {http://dx.doi.org/10.1038/s41597-019-0198-z}, keywords = {MICROSATELLITE INSTABILITY; PROMOTER HYPERMETHYLATION; SERRATED POLYPS; COLON-CANCER; PHENOTYPE; CARCINOGENESIS; ADENOCARCINOMA; BIOMARKERS; PATHWAYS; GENES}, language = {eng}, issn = {2052-4463}, journal = {SCIENTIFIC DATA}, title = {ColPortal, an integrative multiomic platform for analysing epigenetic interactions in colorectal cancer}, url = {https://www.nature.com/articles/s41597-019-0198-z.pdf}, volume = {6}, year = {2019} }
TY - JOUR ID - 1605485 AU - Esteban-Gil, Angel - Perez-Sanz, Fernando - Garcia-Solano, Jose - Alburquerque-Gonzalez, Begona - Parreno-Gonzalez, Maria - Legaz-Garcia, Maria del Carmen - Fernandez-Breis, Jesualdo Tomas - Rodriguez-Braun, Edith - Pimentel, Paola - Tuomisto, Anne - Makinen, Markus - Slabý, Ondřej - Conesa-Zamora, Pablo PY - 2019 TI - ColPortal, an integrative multiomic platform for analysing epigenetic interactions in colorectal cancer JF - SCIENTIFIC DATA VL - 6 IS - OCT 31 2019 SP - 1-14 EP - 1-14 PB - NATURE PUBLISHING GROUP SN - 20524463 KW - MICROSATELLITE INSTABILITY KW - PROMOTER HYPERMETHYLATION KW - SERRATED POLYPS KW - COLON-CANCER KW - PHENOTYPE KW - CARCINOGENESIS KW - ADENOCARCINOMA KW - BIOMARKERS KW - PATHWAYS KW - GENES UR - https://www.nature.com/articles/s41597-019-0198-z.pdf L2 - https://www.nature.com/articles/s41597-019-0198-z.pdf N2 - Colorectal cancer (CRC) is the third leading cause of cancer mortality worldwide. Different pathological pathways and molecular drivers have been described and some of the associated markers are used to select effective anti-neoplastic therapy. More recent evidence points to a causal role of microbiota and altered microRNA expression in CRC carcinogenesis, but their relationship with pathological drivers or molecular phenotypes is not clearly established. Joint analysis of clinical and omics data can help clarify such relations. We present ColPortal, a platform that integrates transcriptomic, microtranscriptomic, methylomic and microbiota data of patients with colorectal cancer. ColPortal also includes detailed information of histological features and digital histological slides from the study cases, since histology is a morphological manifestation of a complex molecular change. The current cohort consists of Caucasian patients from Europe. For each patient, demographic information, location, histology, tumor staging, tissue prognostic factors, molecular biomarker status and clinical outcomes are integrated with omics data. ColPortal allows one to perform multiomics analyses for groups of patients selected by their clinical data. ER -
ESTEBAN-GIL, Angel, Fernando PEREZ-SANZ, Jose GARCIA-SOLANO, Begona ALBURQUERQUE-GONZALEZ, Maria PARRENO-GONZALEZ, Maria del Carmen LEGAZ-GARCIA, Jesualdo Tomas FERNANDEZ-BREIS, Edith RODRIGUEZ-BRAUN, Paola PIMENTEL, Anne TUOMISTO, Markus MAKINEN, Ondřej SLABÝ and Pablo CONESA-ZAMORA. ColPortal, an integrative multiomic platform for analysing epigenetic interactions in colorectal cancer. \textit{SCIENTIFIC DATA}. LONDON: NATURE PUBLISHING GROUP, 2019, vol.~6, OCT 31 2019, p.~1-14. ISSN~2052-4463. Available from: https://dx.doi.org/10.1038/s41597-019-0198-z.
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