REIJNEN, Casper, Willem Jan VAN WEELDEN, Martijn S. J. P. ARTS, Johan P. PETERS, Paul F. RIJKEN, Koen VAN DE VIJVER, Maria SANTACANA, Peter BRONSERT, Johan BULTEN, Marc HIRSCHFELD, Eva COLAS, Antonio GIL-MORENO, Armando REQUES, Gemma MANCEBO, Camilla KRAKSTAD, Jone TROVIK, Ingfrid S. HALDORSEN, Jutta HUVILA, Martin KOSKAS, Vít WEINBERGER, Luboš MINÁŘ, Eva JANDÁKOVÁ, Marc P. L. M. SNIJDERS, Saskia VAN DEN BERG-VAN ERP, Heidi V. N. KUSTERS-VANDEVELDE, Xavier MATIAS-GUIU, Frederic AMANT, Leon F. A. G. MASSUGER, Johan BUSSINK and Johanna M. A. PIJNENBORG. Poor outcome in hypoxic endometrial carcinoma is related to vascular density. British journal of cancer. LONDON: NATURE PUBLISHING GROUP, 2019, vol. 120, No 11, p. 1037-1044. ISSN 0007-0920. Available from: https://dx.doi.org/10.1038/s41416-019-0461-2. |
Other formats:
BibTeX
LaTeX
RIS
@article{1605588, author = {Reijnen, Casper and van Weelden, Willem Jan and Arts, Martijn S. J. P. and Peters, Johan P. and Rijken, Paul F. and van de Vijver, Koen and Santacana, Maria and Bronsert, Peter and Bulten, Johan and Hirschfeld, Marc and Colas, Eva and GilandMoreno, Antonio and Reques, Armando and Mancebo, Gemma and Krakstad, Camilla and Trovik, Jone and Haldorsen, Ingfrid S. and Huvila, Jutta and Koskas, Martin and Weinberger, Vít and Minář, Luboš and Jandáková, Eva and Snijders, Marc P. L. M. and van den Bergandvan Erp, Saskia and KustersandVandevelde, Heidi V. N. and MatiasandGuiu, Xavier and Amant, Frederic and Massuger, Leon F. A. G. and Bussink, Johan and Pijnenborg, Johanna M. A.}, article_location = {LONDON}, article_number = {11}, doi = {http://dx.doi.org/10.1038/s41416-019-0461-2}, keywords = {CARBONIC-ANHYDRASE-IX; LYMPH-NODE METASTASIS; PROGNOSTIC-SIGNIFICANCE; MICROVESSEL DENSITY; INDUCIBLE FACTOR-1; SPACE INVASION; BREAST-CANCER; TUMOR HYPOXIA; EXPRESSION; ANGIOGENESIS}, language = {eng}, issn = {0007-0920}, journal = {British journal of cancer}, title = {Poor outcome in hypoxic endometrial carcinoma is related to vascular density}, url = {http://dx.doi.org/10.1038/s41416-019-0461-2}, volume = {120}, year = {2019} }
TY - JOUR ID - 1605588 AU - Reijnen, Casper - van Weelden, Willem Jan - Arts, Martijn S. J. P. - Peters, Johan P. - Rijken, Paul F. - van de Vijver, Koen - Santacana, Maria - Bronsert, Peter - Bulten, Johan - Hirschfeld, Marc - Colas, Eva - Gil-Moreno, Antonio - Reques, Armando - Mancebo, Gemma - Krakstad, Camilla - Trovik, Jone - Haldorsen, Ingfrid S. - Huvila, Jutta - Koskas, Martin - Weinberger, Vít - Minář, Luboš - Jandáková, Eva - Snijders, Marc P. L. M. - van den Berg-van Erp, Saskia - Kusters-Vandevelde, Heidi V. N. - Matias-Guiu, Xavier - Amant, Frederic - Massuger, Leon F. A. G. - Bussink, Johan - Pijnenborg, Johanna M. A. PY - 2019 TI - Poor outcome in hypoxic endometrial carcinoma is related to vascular density JF - British journal of cancer VL - 120 IS - 11 SP - 1037-1044 EP - 1037-1044 PB - NATURE PUBLISHING GROUP SN - 00070920 KW - CARBONIC-ANHYDRASE-IX KW - LYMPH-NODE METASTASIS KW - PROGNOSTIC-SIGNIFICANCE KW - MICROVESSEL DENSITY KW - INDUCIBLE FACTOR-1 KW - SPACE INVASION KW - BREAST-CANCER KW - TUMOR HYPOXIA KW - EXPRESSION KW - ANGIOGENESIS UR - http://dx.doi.org/10.1038/s41416-019-0461-2 L2 - http://dx.doi.org/10.1038/s41416-019-0461-2 N2 - BACKGROUND: Identification of endometrial carcinoma (EC) patients at high risk of recurrence is lacking. In this study, the prognostic role of hypoxia and angiogenesis was investigated in EC patients. METHODS: Tumour slides from EC patients were stained by immunofluorescence for carbonic anhydrase IX (CAIX) as hypoxic marker and CD34 for assessment of microvessel density (MVD). CAIX expression was determined in epithelial tumour cells, with a cut-off of 1%. MVD was assessed according to the Weidner method. Correlations with disease-specific survival (DSS), disease-free survival (DFS) and distant disease-free survival (DDFS) were calculated using Kaplan-Meier curves and Cox regression analysis. RESULTS: Sixty-three (16.4%) of 385 ECs showed positive CAIX expression with high vascular density. These ECs had a reduced DSS compared to tumours with either hypoxia or high vascular density (log-rank p = 0.002). Multivariable analysis showed that hypoxic tumours with high vascular density had a reduced DSS (hazard ratio [HR] 3.71, p = 0.002), DDFS (HR 2.68, p = 0.009) and a trend for reduced DFS (HR 1.87, p = 0.054). CONCLUSIONS: This study has shown that adverse outcome in hypoxic ECs is seen in the presence of high vascular density, suggesting an important role of angiogenesis in the metastatic process of hypoxic EC. Differential adjuvant treatment might be indicated for these patients. ER -
REIJNEN, Casper, Willem Jan VAN WEELDEN, Martijn S. J. P. ARTS, Johan P. PETERS, Paul F. RIJKEN, Koen VAN DE VIJVER, Maria SANTACANA, Peter BRONSERT, Johan BULTEN, Marc HIRSCHFELD, Eva COLAS, Antonio GIL-MORENO, Armando REQUES, Gemma MANCEBO, Camilla KRAKSTAD, Jone TROVIK, Ingfrid S. HALDORSEN, Jutta HUVILA, Martin KOSKAS, Vít WEINBERGER, Luboš MINÁŘ, Eva JANDÁKOVÁ, Marc P. L. M. SNIJDERS, Saskia VAN DEN BERG-VAN ERP, Heidi V. N. KUSTERS-VANDEVELDE, Xavier MATIAS-GUIU, Frederic AMANT, Leon F. A. G. MASSUGER, Johan BUSSINK and Johanna M. A. PIJNENBORG. Poor outcome in hypoxic endometrial carcinoma is related to vascular density. \textit{British journal of cancer}. LONDON: NATURE PUBLISHING GROUP, 2019, vol.~120, No~11, p.~1037-1044. ISSN~0007-0920. Available from: https://dx.doi.org/10.1038/s41416-019-0461-2.
|