Poor outcome in hypoxic endometrial carcinoma is related to
vascular density

J 2019

Poor outcome in hypoxic endometrial carcinoma is related to vascular density

REIJNEN, Casper, Willem Jan VAN WEELDEN, Martijn S. J. P. ARTS, Johan P. PETERS, Paul F. RIJKEN et. al.

Basic information

Original name

Poor outcome in hypoxic endometrial carcinoma is related to vascular density

Authors

REIJNEN, Casper (528 Netherlands, guarantor), Willem Jan VAN WEELDEN (528 Netherlands), Martijn S. J. P. ARTS (528 Netherlands), Johan P. PETERS (528 Netherlands), Paul F. RIJKEN (528 Netherlands), Koen VAN DE VIJVER (56 Belgium), Maria SANTACANA (724 Spain), Peter BRONSERT (276 Germany), Johan BULTEN (528 Netherlands), Marc HIRSCHFELD (276 Germany), Eva COLAS (724 Spain), Antonio GIL-MORENO (724 Spain), Armando REQUES (724 Spain), Gemma MANCEBO (724 Spain), Camilla KRAKSTAD (578 Norway), Jone TROVIK (578 Norway), Ingfrid S. HALDORSEN (578 Norway), Jutta HUVILA (246 Finland), Martin KOSKAS (250 France), Vít WEINBERGER (203 Czech Republic, belonging to the institution), Luboš MINÁŘ (203 Czech Republic, belonging to the institution), Eva JANDÁKOVÁ (203 Czech Republic, belonging to the institution), Marc P. L. M. SNIJDERS (528 Netherlands), Saskia VAN DEN BERG-VAN ERP (528 Netherlands), Heidi V. N. KUSTERS-VANDEVELDE (528 Netherlands), Xavier MATIAS-GUIU (724 Spain), Frederic AMANT (56 Belgium), Leon F. A. G. MASSUGER (528 Netherlands), Johan BUSSINK (528 Netherlands) and Johanna M. A. PIJNENBORG (528 Netherlands)

Edition

British journal of cancer, LONDON, NATURE PUBLISHING GROUP, 2019, 0007-0920

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.791

RIV identification code

RIV/00216224:14110/19:00112513

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1038/s41416-019-0461-2

UT WoS

000469218100004

Keywords in English

CARBONIC-ANHYDRASE-IX; LYMPH-NODE METASTASIS; PROGNOSTIC-SIGNIFICANCE; MICROVESSEL DENSITY; INDUCIBLE FACTOR-1; SPACE INVASION; BREAST-CANCER; TUMOR HYPOXIA; EXPRESSION; ANGIOGENESIS

Abstract

V originále

BACKGROUND: Identification of endometrial carcinoma (EC) patients at high risk of recurrence is lacking. In this study, the prognostic role of hypoxia and angiogenesis was investigated in EC patients. METHODS: Tumour slides from EC patients were stained by immunofluorescence for carbonic anhydrase IX (CAIX) as hypoxic marker and CD34 for assessment of microvessel density (MVD). CAIX expression was determined in epithelial tumour cells, with a cut-off of 1%. MVD was assessed according to the Weidner method. Correlations with disease-specific survival (DSS), disease-free survival (DFS) and distant disease-free survival (DDFS) were calculated using Kaplan-Meier curves and Cox regression analysis. RESULTS: Sixty-three (16.4%) of 385 ECs showed positive CAIX expression with high vascular density. These ECs had a reduced DSS compared to tumours with either hypoxia or high vascular density (log-rank p = 0.002). Multivariable analysis showed that hypoxic tumours with high vascular density had a reduced DSS (hazard ratio [HR] 3.71, p = 0.002), DDFS (HR 2.68, p = 0.009) and a trend for reduced DFS (HR 1.87, p = 0.054). CONCLUSIONS: This study has shown that adverse outcome in hypoxic ECs is seen in the presence of high vascular density, suggesting an important role of angiogenesis in the metastatic process of hypoxic EC. Differential adjuvant treatment might be indicated for these patients.

Citovat

REIJNEN, Casper, Willem Jan VAN WEELDEN, Martijn S. J. P. ARTS, Johan P. PETERS, Paul F. RIJKEN, Koen VAN DE VIJVER, Maria SANTACANA, Peter BRONSERT, Johan BULTEN, Marc HIRSCHFELD, Eva COLAS, Antonio GIL-MORENO, Armando REQUES, Gemma MANCEBO, Camilla KRAKSTAD, Jone TROVIK, Ingfrid S. HALDORSEN, Jutta HUVILA, Martin KOSKAS, Vít WEINBERGER, Luboš MINÁŘ, Eva JANDÁKOVÁ, Marc P. L. M. SNIJDERS, Saskia VAN DEN BERG-VAN ERP, Heidi V. N. KUSTERS-VANDEVELDE, Xavier MATIAS-GUIU, Frederic AMANT, Leon F. A. G. MASSUGER, Johan BUSSINK and Johanna M. A. PIJNENBORG. Poor outcome in hypoxic endometrial carcinoma is related to vascular density. British journal of cancer. LONDON: NATURE PUBLISHING GROUP, 2019, vol. 120, No 11, p. 1037-1044. ISSN 0007-0920. Available from: https://dx.doi.org/10.1038/s41416-019-0461-2.

@article{1605588,
   author = {Reijnen, Casper and van Weelden, Willem Jan and Arts, Martijn S. J. P. and Peters, Johan P. and Rijken, Paul F. and van de Vijver, Koen and Santacana, Maria and Bronsert, Peter and Bulten, Johan and Hirschfeld, Marc and Colas, Eva and GilandMoreno, Antonio and Reques, Armando and Mancebo, Gemma and Krakstad, Camilla and Trovik, Jone and Haldorsen, Ingfrid S. and Huvila, Jutta and Koskas, Martin and Weinberger, Vít and Minář, Luboš and Jandáková, Eva and Snijders, Marc P. L. M. and van den Bergandvan Erp, Saskia and KustersandVandevelde, Heidi V. N. and MatiasandGuiu, Xavier and Amant, Frederic and Massuger, Leon F. A. G. and Bussink, Johan and Pijnenborg, Johanna M. A.},
   article_location = {LONDON},
   article_number = {11},
   doi = {http://dx.doi.org/10.1038/s41416-019-0461-2},
   keywords = {CARBONIC-ANHYDRASE-IX; LYMPH-NODE METASTASIS; PROGNOSTIC-SIGNIFICANCE; MICROVESSEL DENSITY; INDUCIBLE FACTOR-1; SPACE INVASION; BREAST-CANCER; TUMOR HYPOXIA; EXPRESSION; ANGIOGENESIS},
   language = {eng},
   issn = {0007-0920},
   journal = {British journal of cancer},
   title = {Poor outcome in hypoxic endometrial carcinoma is related to vascular density},
   url = {http://dx.doi.org/10.1038/s41416-019-0461-2},
   volume = {120},
   year = {2019}
}

TY  - JOUR
ID  - 1605588
AU  - Reijnen, Casper - van Weelden, Willem Jan - Arts, Martijn S. J. P. - Peters, Johan P. - Rijken, Paul F. - van de Vijver, Koen - Santacana, Maria - Bronsert, Peter - Bulten, Johan - Hirschfeld, Marc - Colas, Eva - Gil-Moreno, Antonio - Reques, Armando - Mancebo, Gemma - Krakstad, Camilla - Trovik, Jone - Haldorsen, Ingfrid S. - Huvila, Jutta - Koskas, Martin - Weinberger, Vít - Minář, Luboš - Jandáková, Eva - Snijders, Marc P. L. M. - van den Berg-van Erp, Saskia - Kusters-Vandevelde, Heidi V. N. - Matias-Guiu, Xavier - Amant, Frederic - Massuger, Leon F. A. G. - Bussink, Johan - Pijnenborg, Johanna M. A.
PY  - 2019
TI  - Poor outcome in hypoxic endometrial carcinoma is related to vascular density
JF  - British journal of cancer
VL  - 120
IS  - 11
SP  - 1037-1044
EP  - 1037-1044
PB  - NATURE PUBLISHING GROUP
SN  - 00070920
KW  - CARBONIC-ANHYDRASE-IX
KW  - LYMPH-NODE METASTASIS
KW  - PROGNOSTIC-SIGNIFICANCE
KW  - MICROVESSEL DENSITY
KW  - INDUCIBLE FACTOR-1
KW  - SPACE INVASION
KW  - BREAST-CANCER
KW  - TUMOR HYPOXIA
KW  - EXPRESSION
KW  - ANGIOGENESIS
UR  - http://dx.doi.org/10.1038/s41416-019-0461-2
L2  - http://dx.doi.org/10.1038/s41416-019-0461-2
N2  - BACKGROUND: Identification of endometrial carcinoma (EC) patients at high risk of recurrence is lacking. In this study, the prognostic role of hypoxia and angiogenesis was investigated in EC patients. METHODS: Tumour slides from EC patients were stained by immunofluorescence for carbonic anhydrase IX (CAIX) as hypoxic marker and CD34 for assessment of microvessel density (MVD). CAIX expression was determined in epithelial tumour cells, with a cut-off of 1%. MVD was assessed according to the Weidner method. Correlations with disease-specific survival (DSS), disease-free survival (DFS) and distant disease-free survival (DDFS) were calculated using Kaplan-Meier curves and Cox regression analysis. RESULTS: Sixty-three (16.4%) of 385 ECs showed positive CAIX expression with high vascular density. These ECs had a reduced DSS compared to tumours with either hypoxia or high vascular density (log-rank p = 0.002). Multivariable analysis showed that hypoxic tumours with high vascular density had a reduced DSS (hazard ratio [HR] 3.71, p = 0.002), DDFS (HR 2.68, p = 0.009) and a trend for reduced DFS (HR 1.87, p = 0.054). CONCLUSIONS: This study has shown that adverse outcome in hypoxic ECs is seen in the presence of high vascular density, suggesting an important role of angiogenesis in the metastatic process of hypoxic EC. Differential adjuvant treatment might be indicated for these patients.
ER  -

REIJNEN, Casper, Willem Jan VAN WEELDEN, Martijn S. J. P. ARTS, Johan P. PETERS, Paul F. RIJKEN, Koen VAN DE VIJVER, Maria SANTACANA, Peter BRONSERT, Johan BULTEN, Marc HIRSCHFELD, Eva COLAS, Antonio GIL-MORENO, Armando REQUES, Gemma MANCEBO, Camilla KRAKSTAD, Jone TROVIK, Ingfrid S. HALDORSEN, Jutta HUVILA, Martin KOSKAS, Vít WEINBERGER, Luboš MINÁŘ, Eva JANDÁKOVÁ, Marc P. L. M. SNIJDERS, Saskia VAN DEN BERG-VAN ERP, Heidi V. N. KUSTERS-VANDEVELDE, Xavier MATIAS-GUIU, Frederic AMANT, Leon F. A. G. MASSUGER, Johan BUSSINK and Johanna M. A. PIJNENBORG. Poor outcome in hypoxic endometrial carcinoma is related to vascular density. \textit{British journal of cancer}. LONDON: NATURE PUBLISHING GROUP, 2019, vol.~120, No~11, p.~1037-1044. ISSN~0007-0920. Available from: https://dx.doi.org/10.1038/s41416-019-0461-2.

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