| MICHÁLEK, Jaroslav, Světlana BRYCHTOVÁ, Richard PINK a Zdeněk DVOŘÁK. Prognostic and predictive markers for perineural and bone invasion of oral squamous cell carcinoma. Biomedical Papers. Olomouc: Univerzita Palackého v Olomouci, 2019, roč. 163, č. 4, s. 302-308. ISSN 1213-8118. Dostupné z: https://dx.doi.org/10.5507/bp.2019.032. |
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@article{1606181,
author = {Michálek, Jaroslav and Brychtová, Světlana and Pink, Richard and Dvořák, Zdeněk},
article_location = {Olomouc},
article_number = {4},
doi = {http://dx.doi.org/10.5507/bp.2019.032},
keywords = {squamous cell carcinoma; oral cavity and oropharynx; bone invasion; perineural invasion},
language = {eng},
issn = {1213-8118},
journal = {Biomedical Papers},
title = {Prognostic and predictive markers for perineural and bone invasion of oral squamous cell carcinoma},
url = {https://biomed.papers.upol.cz/artkey/bio-201904-0003_prognostic-and-predictive-markers-for-perineural-and-bone-invasion-of-oral-squamous-cell-carcinoma.php},
volume = {163},
year = {2019}
}
TY - JOUR
ID - 1606181
AU - Michálek, Jaroslav - Brychtová, Světlana - Pink, Richard - Dvořák, Zdeněk
PY - 2019
TI - Prognostic and predictive markers for perineural and bone invasion of oral squamous cell carcinoma
JF - Biomedical Papers
VL - 163
IS - 4
SP - 302-308
EP - 302-308
PB - Univerzita Palackého v Olomouci
SN - 12138118
KW - squamous cell carcinoma
KW - oral cavity and oropharynx
KW - bone invasion
KW - perineural invasion
UR - https://biomed.papers.upol.cz/artkey/bio-201904-0003_prognostic-and-predictive-markers-for-perineural-and-bone-invasion-of-oral-squamous-cell-carcinoma.php
L2 - https://biomed.papers.upol.cz/artkey/bio-201904-0003_prognostic-and-predictive-markers-for-perineural-and-bone-invasion-of-oral-squamous-cell-carcinoma.php
N2 - Oral squamous cell carcinoma (OSCC) is a growing problem worldwide. Several biological and molecular criteria have been established for making a prognosis of OSCC. One of the most important factors affecting the risk of tumor recurrence and overall prognosis is perineural invasion and bone invasion. Perineural invasion is defined as a tumor spreading and the ability of tumor cells to penetrate around or through the nerve tissue. Perineural invasion can cause the tumor to spread to distant areas from the primary tumor location. One possible explanation for this is the formation of microenvironment in the perineural space which may contain cellular factors that act on both nerve tissue and some types of tumor tissues. Bone invasion by OSCC has major implications for tumor staging, choice of treatment, outcome and quality of life. Oral SCCs invade the mandibular or maxillary bone through an erosive, infiltrative or mixed pattern that correlates with clinical behavior. Bone resorption by osteoclasts is an important step in the process of bone invasion by oral SCCs. Some cytokines (e.g. TNFa and PTHrP) lead to receptor activator of NF-kB ligand (RANKL) expression or osteoprotegerin (OPG) suppression in oral SCC cells and in cancer stromal cells to induce osteoclastogenesis. Oral SCCs provide a suitable microenvironment for osteoclastogenesis to regulate the balance of RANKL and OPG. A more molecular-based clinical staging and tailor-made therapy would benefit patients with bone invasion by OSCC.
ER -
MICHÁLEK, Jaroslav, Světlana BRYCHTOVÁ, Richard PINK a Zdeněk DVOŘÁK. Prognostic and predictive markers for perineural and bone invasion of oral squamous cell carcinoma. \textit{Biomedical Papers}. Olomouc: Univerzita Palackého v Olomouci, 2019, roč.~163, č.~4, s.~302-308. ISSN~1213-8118. Dostupné z: https://dx.doi.org/10.5507/bp.2019.032.
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