| ŠIPULA, David, Milan KOZÁK, Jaroslav SIPULA, Miroslav HOMZA a Jiri PLASEK. Cardiac strains as a tool for optimization of cardiac resynchronization therapy in non-responders: a pilot study. Open Medicine. Warsaw: Walter De Gruyter, 2019, roč. 14, č. 1, s. 945-952. ISSN 2391-5463. Dostupné z: https://dx.doi.org/10.1515/med-2019-0111. |
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@article{1606836,
author = {Šipula, David and Kozák, Milan and Sipula, Jaroslav and Homza, Miroslav and Plasek, Jiri},
article_location = {Warsaw},
article_number = {1},
doi = {http://dx.doi.org/10.1515/med-2019-0111},
keywords = {Cardiac Resynchronization Therapy; Heart Failure; Optimization; Speckle Tracking; Cardiac Strains},
language = {eng},
issn = {2391-5463},
journal = {Open Medicine},
title = {Cardiac strains as a tool for optimization of cardiac resynchronization therapy in non-responders: a pilot study},
url = {http://dx.doi.org/10.1515/med-2019-0111},
volume = {14},
year = {2019}
}
TY - JOUR
ID - 1606836
AU - Šipula, David - Kozák, Milan - Sipula, Jaroslav - Homza, Miroslav - Plasek, Jiri
PY - 2019
TI - Cardiac strains as a tool for optimization of cardiac resynchronization therapy in non-responders: a pilot study
JF - Open Medicine
VL - 14
IS - 1
SP - 945-952
EP - 945-952
PB - Walter De Gruyter
SN - 23915463
KW - Cardiac Resynchronization Therapy
KW - Heart Failure
KW - Optimization
KW - Speckle Tracking
KW - Cardiac Strains
UR - http://dx.doi.org/10.1515/med-2019-0111
L2 - http://dx.doi.org/10.1515/med-2019-0111
N2 - Background. Approximately 30% of patients do not respond to implantation of Cardiac Resynchronization Therapy - Defibrillators (CRT-D). The aim of this study was to investigate the potential for cardiac strain speckle tracking to optimize the performance of CRT-D in non-responding patients. Methods. 30 patients not responding to Cardiac Resynchronization Therapy-Defibrillators after 3 months were randomly divided into control and intervention groups. Atrioventricular interval was adjusted so that E and A waves did not overlap, the interventricular interval was subsequently optimized to yield maximum improvement of the sum of longitudinal+radial+circumferential strains. The left ventricular ejection fraction (LVEF) and NYHA improvement 3 months after optimization were evaluated and use of other strain combinations assessed. Results. A significant correlation between the (combined) strain change and LVEF improvement was detected (p<0.01). 75% of patients with non-ischemic etiology of heart failure who did not respond to the original CRT-D reacted favorably with significant LVEF and NYHA improvement. The area strain was the best predictor of LVEF/NYHA improvement in those patients. No significant improvement was recorded in patients with ischemic etiology. Conclusions. AV and VV optimization based on speckle tracking is a very promising method potentially leading to a significant improvement of the outcome of CRT-D, especially in patients with non-ischemic etiology of heart failure.
ER -
ŠIPULA, David, Milan KOZÁK, Jaroslav SIPULA, Miroslav HOMZA a Jiri PLASEK. Cardiac strains as a tool for optimization of cardiac resynchronization therapy in non-responders: a pilot study. \textit{Open Medicine}. Warsaw: Walter De Gruyter, 2019, roč.~14, č.~1, s.~945-952. ISSN~2391-5463. Dostupné z: https://dx.doi.org/10.1515/med-2019-0111.
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