Detailed Information on Publication Record
2019
Cardiac strains as a tool for optimization of cardiac resynchronization therapy in non-responders: a pilot study
ŠIPULA, David, Milan KOZÁK, Jaroslav SIPULA, Miroslav HOMZA, Jiri PLASEK et. al.Basic information
Original name
Cardiac strains as a tool for optimization of cardiac resynchronization therapy in non-responders: a pilot study
Authors
ŠIPULA, David (203 Czech Republic, guarantor, belonging to the institution), Milan KOZÁK (203 Czech Republic, belonging to the institution), Jaroslav SIPULA (203 Czech Republic), Miroslav HOMZA (203 Czech Republic) and Jiri PLASEK (203 Czech Republic)
Edition
Open Medicine, Warsaw, Walter De Gruyter, 2019, 2391-5463
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30201 Cardiac and Cardiovascular systems
Country of publisher
Poland
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 1.204
RIV identification code
RIV/00216224:14110/19:00112594
Organization unit
Faculty of Medicine
UT WoS
000501996200002
Keywords in English
Cardiac Resynchronization Therapy; Heart Failure; Optimization; Speckle Tracking; Cardiac Strains
Tags
International impact, Reviewed
Změněno: 20/1/2020 07:59, Mgr. Tereza Miškechová
Abstract
V originále
Background. Approximately 30% of patients do not respond to implantation of Cardiac Resynchronization Therapy - Defibrillators (CRT-D). The aim of this study was to investigate the potential for cardiac strain speckle tracking to optimize the performance of CRT-D in non-responding patients. Methods. 30 patients not responding to Cardiac Resynchronization Therapy-Defibrillators after 3 months were randomly divided into control and intervention groups. Atrioventricular interval was adjusted so that E and A waves did not overlap, the interventricular interval was subsequently optimized to yield maximum improvement of the sum of longitudinal+radial+circumferential strains. The left ventricular ejection fraction (LVEF) and NYHA improvement 3 months after optimization were evaluated and use of other strain combinations assessed. Results. A significant correlation between the (combined) strain change and LVEF improvement was detected (p<0.01). 75% of patients with non-ischemic etiology of heart failure who did not respond to the original CRT-D reacted favorably with significant LVEF and NYHA improvement. The area strain was the best predictor of LVEF/NYHA improvement in those patients. No significant improvement was recorded in patients with ischemic etiology. Conclusions. AV and VV optimization based on speckle tracking is a very promising method potentially leading to a significant improvement of the outcome of CRT-D, especially in patients with non-ischemic etiology of heart failure.