Structural and functional MRI correlates of T2 hyperintensities
of brain white matter in young neurologically asymptomatic
adults

J 2019

Structural and functional MRI correlates of T2 hyperintensities of brain white matter in young neurologically asymptomatic adults

KEŘKOVSKÝ, Miloš, Jakub STULÍK, Marek DOSTÁL, Matyáš KUHN, Jan LOŠÁK et. al.

Basic information

Original name

Structural and functional MRI correlates of T2 hyperintensities of brain white matter in young neurologically asymptomatic adults

Authors

KEŘKOVSKÝ, Miloš (203 Czech Republic, guarantor, belonging to the institution), Jakub STULÍK (203 Czech Republic, belonging to the institution), Marek DOSTÁL (203 Czech Republic, belonging to the institution), Matyáš KUHN (203 Czech Republic, belonging to the institution), Jan LOŠÁK (203 Czech Republic, belonging to the institution), Petra PRAKSOVÁ (203 Czech Republic, belonging to the institution), Monika HULOVÁ (203 Czech Republic, belonging to the institution), Josef BEDNAŘÍK (203 Czech Republic, belonging to the institution), Andrea ŠPRLÁKOVÁ-PUKOVÁ (203 Czech Republic, belonging to the institution) and Marek MECHL (203 Czech Republic, belonging to the institution)

Edition

European Radiology, New York, Springer, 2019, 0938-7994

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30224 Radiology, nuclear medicine and medical imaging

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.101

RIV identification code

RIV/00216224:14110/19:00108573

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1007/s00330-019-06268-8

UT WoS

000500979400066

Keywords in English

White matter; Healthy volunteers; Diffusion tensor imaging; Functional magnetic resonance imaging

Abstract

V originále

Objectives Although white matter hyperintensities (WMHs) are quite commonly found incidentally, their aetiology, structural characteristics, and functional consequences are not entirely known. The purpose of this study was to quantify WMHs in a sample of young, neurologically asymptomatic adults and evaluate the structural and functional correlations of lesion load with changes in brain volume, diffusivity, and functional connectivity. Methods MRI brain scan using multimodal protocol was performed in 60 neurologically asymptomatic volunteers (21 men, 39 women, mean age 34.5 years). WMHs were manually segmented in 3D FLAIR images and counted automatically. The number and volume of WMHs were correlated with brain volume, resting-state functional MRI (rs-fMRI), and diffusion tensor imaging (DTI) data. Diffusion parameters measured within WMHs and normally appearing white matter (NAWM) were compared. Results At least 1 lesion was found in 40 (67%) subjects, median incidence was 1 lesion (interquartile range [IQR]=4.5), and median volume was 86.82 (IQR=227.23) mm(3). Neither number nor volume of WMHs correlated significantly with total brain volume or volumes of white and grey matter. Mean diffusivity values within WMHs were significantly higher compared with those for NAWM, but none of the diffusion parameters of NAWM were significantly correlated with WMH load. Both the number and volume of WMHs were correlated with the changes of functional connectivity between several regions of the brain, mostly decreased connectivity of the cerebellum. Conclusions WMHs are commonly found even in young, neurologically asymptomatic adults. Their presence is not associated with brain atrophy or global changes of diffusivity, but the increasing number and volume of these lesions correlate with changes of brain connectivity, and especially that of the cerebellum.

Links

NV15-32133A, research and development project

Name: Predikce konverze klinicky izolovaného syndromu do roztroušené sklerózy pomocí pokročilých technik zobrazení magnetickou rezonancí

ROZV/24/LF/2018, interní kód MU

Name: LF - Příspěvek na IP 2108

Investor: Ministry of Education, Youth and Sports of the CR, Internal development projects

Citovat

KEŘKOVSKÝ, Miloš, Jakub STULÍK, Marek DOSTÁL, Matyáš KUHN, Jan LOŠÁK, Petra PRAKSOVÁ, Monika HULOVÁ, Josef BEDNAŘÍK, Andrea ŠPRLÁKOVÁ-PUKOVÁ and Marek MECHL. Structural and functional MRI correlates of T2 hyperintensities of brain white matter in young neurologically asymptomatic adults. European Radiology. New York: Springer, 2019, vol. 29, No 12, p. 7027-7036. ISSN 0938-7994. Available from: https://dx.doi.org/10.1007/s00330-019-06268-8.

@article{1606859,
   author = {Keřkovský, Miloš and Stulík, Jakub and Dostál, Marek and Kuhn, Matyáš and Lošák, Jan and Praksová, Petra and Hulová, Monika and Bednařík, Josef and ŠprlákováandPuková, Andrea and Mechl, Marek},
   article_location = {New York},
   article_number = {12},
   doi = {http://dx.doi.org/10.1007/s00330-019-06268-8},
   keywords = {White matter; Healthy volunteers; Diffusion tensor imaging; Functional magnetic resonance imaging},
   language = {eng},
   issn = {0938-7994},
   journal = {European Radiology},
   title = {Structural and functional MRI correlates of T2 hyperintensities of brain white matter in young neurologically asymptomatic adults},
   url = {http://dx.doi.org/10.1007/s00330-019-06268-8},
   volume = {29},
   year = {2019}
}

TY  - JOUR
ID  - 1606859
AU  - Keřkovský, Miloš - Stulík, Jakub - Dostál, Marek - Kuhn, Matyáš - Lošák, Jan - Praksová, Petra - Hulová, Monika - Bednařík, Josef - Šprláková-Puková, Andrea - Mechl, Marek
PY  - 2019
TI  - Structural and functional MRI correlates of T2 hyperintensities of brain white matter in young neurologically asymptomatic adults
JF  - European Radiology
VL  - 29
IS  - 12
SP  - 7027-7036
EP  - 7027-7036
PB  - Springer
SN  - 09387994
KW  - White matter
KW  - Healthy volunteers
KW  - Diffusion tensor imaging
KW  - Functional magnetic resonance imaging
UR  - http://dx.doi.org/10.1007/s00330-019-06268-8
L2  - http://dx.doi.org/10.1007/s00330-019-06268-8
N2  - Objectives Although white matter hyperintensities (WMHs) are quite commonly found incidentally, their aetiology, structural characteristics, and functional consequences are not entirely known. The purpose of this study was to quantify WMHs in a sample of young, neurologically asymptomatic adults and evaluate the structural and functional correlations of lesion load with changes in brain volume, diffusivity, and functional connectivity. Methods MRI brain scan using multimodal protocol was performed in 60 neurologically asymptomatic volunteers (21 men, 39 women, mean age 34.5 years). WMHs were manually segmented in 3D FLAIR images and counted automatically. The number and volume of WMHs were correlated with brain volume, resting-state functional MRI (rs-fMRI), and diffusion tensor imaging (DTI) data. Diffusion parameters measured within WMHs and normally appearing white matter (NAWM) were compared. Results At least 1 lesion was found in 40 (67%) subjects, median incidence was 1 lesion (interquartile range [IQR]=4.5), and median volume was 86.82 (IQR=227.23) mm(3). Neither number nor volume of WMHs correlated significantly with total brain volume or volumes of white and grey matter. Mean diffusivity values within WMHs were significantly higher compared with those for NAWM, but none of the diffusion parameters of NAWM were significantly correlated with WMH load. Both the number and volume of WMHs were correlated with the changes of functional connectivity between several regions of the brain, mostly decreased connectivity of the cerebellum. Conclusions WMHs are commonly found even in young, neurologically asymptomatic adults. Their presence is not associated with brain atrophy or global changes of diffusivity, but the increasing number and volume of these lesions correlate with changes of brain connectivity, and especially that of the cerebellum.
ER  -

KEŘKOVSKÝ, Miloš, Jakub STULÍK, Marek DOSTÁL, Matyáš KUHN, Jan LOŠÁK, Petra PRAKSOVÁ, Monika HULOVÁ, Josef BEDNAŘÍK, Andrea ŠPRLÁKOVÁ-PUKOVÁ and Marek MECHL. Structural and functional MRI correlates of T2 hyperintensities of brain white matter in young neurologically asymptomatic adults. \textit{European Radiology}. New York: Springer, 2019, vol.~29, No~12, p.~7027-7036. ISSN~0938-7994. Available from: https://dx.doi.org/10.1007/s00330-019-06268-8.

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