Detailed Information on Publication Record
2019
Structural and functional MRI correlates of T2 hyperintensities of brain white matter in young neurologically asymptomatic adults
KEŘKOVSKÝ, Miloš, Jakub STULÍK, Marek DOSTÁL, Matyáš KUHN, Jan LOŠÁK et. al.Basic information
Original name
Structural and functional MRI correlates of T2 hyperintensities of brain white matter in young neurologically asymptomatic adults
Authors
KEŘKOVSKÝ, Miloš (203 Czech Republic, guarantor, belonging to the institution), Jakub STULÍK (203 Czech Republic, belonging to the institution), Marek DOSTÁL (203 Czech Republic, belonging to the institution), Matyáš KUHN (203 Czech Republic, belonging to the institution), Jan LOŠÁK (203 Czech Republic, belonging to the institution), Petra PRAKSOVÁ (203 Czech Republic, belonging to the institution), Monika HULOVÁ (203 Czech Republic, belonging to the institution), Josef BEDNAŘÍK (203 Czech Republic, belonging to the institution), Andrea ŠPRLÁKOVÁ-PUKOVÁ (203 Czech Republic, belonging to the institution) and Marek MECHL (203 Czech Republic, belonging to the institution)
Edition
European Radiology, New York, Springer, 2019, 0938-7994
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30224 Radiology, nuclear medicine and medical imaging
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 4.101
RIV identification code
RIV/00216224:14110/19:00108573
Organization unit
Faculty of Medicine
UT WoS
000500979400066
Keywords in English
White matter; Healthy volunteers; Diffusion tensor imaging; Functional magnetic resonance imaging
Tags
International impact, Reviewed
Změněno: 31/3/2020 22:15, Mgr. Pavla Foltynová, Ph.D.
Abstract
V originále
Objectives Although white matter hyperintensities (WMHs) are quite commonly found incidentally, their aetiology, structural characteristics, and functional consequences are not entirely known. The purpose of this study was to quantify WMHs in a sample of young, neurologically asymptomatic adults and evaluate the structural and functional correlations of lesion load with changes in brain volume, diffusivity, and functional connectivity. Methods MRI brain scan using multimodal protocol was performed in 60 neurologically asymptomatic volunteers (21 men, 39 women, mean age 34.5 years). WMHs were manually segmented in 3D FLAIR images and counted automatically. The number and volume of WMHs were correlated with brain volume, resting-state functional MRI (rs-fMRI), and diffusion tensor imaging (DTI) data. Diffusion parameters measured within WMHs and normally appearing white matter (NAWM) were compared. Results At least 1 lesion was found in 40 (67%) subjects, median incidence was 1 lesion (interquartile range [IQR]=4.5), and median volume was 86.82 (IQR=227.23) mm(3). Neither number nor volume of WMHs correlated significantly with total brain volume or volumes of white and grey matter. Mean diffusivity values within WMHs were significantly higher compared with those for NAWM, but none of the diffusion parameters of NAWM were significantly correlated with WMH load. Both the number and volume of WMHs were correlated with the changes of functional connectivity between several regions of the brain, mostly decreased connectivity of the cerebellum. Conclusions WMHs are commonly found even in young, neurologically asymptomatic adults. Their presence is not associated with brain atrophy or global changes of diffusivity, but the increasing number and volume of these lesions correlate with changes of brain connectivity, and especially that of the cerebellum.
Links
| NV15-32133A, research and development project |
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| ROZV/24/LF/2018, interní kód MU |
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