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@article{1607098, author = {Slouka, David and Kucera, Radek and Gál, Břetislav and Betka, Jaroslav and Skalova, Alena}, article_location = {Munsbach}, article_number = {2}, keywords = {Obstructive sleep apnea syndrome; monitoring; biomarker; blood level; pentraxin-3s}, language = {eng}, issn = {0172-780X}, journal = {Neuroendocrinology Letters}, title = {Biomarkers - a possibility for monitoring of obstructive sleep apnea syndrome}, url = {https://www.ncbi.nlm.nih.gov/pubmed/31785215}, volume = {40}, year = {2019} }
TY - JOUR ID - 1607098 AU - Slouka, David - Kucera, Radek - Gál, Břetislav - Betka, Jaroslav - Skalova, Alena PY - 2019 TI - Biomarkers - a possibility for monitoring of obstructive sleep apnea syndrome JF - Neuroendocrinology Letters VL - 40 IS - 2 SP - 85-92 EP - 85-92 PB - Maghira & Maas publications SN - 0172780X KW - Obstructive sleep apnea syndrome KW - monitoring KW - biomarker KW - blood level KW - pentraxin-3s UR - https://www.ncbi.nlm.nih.gov/pubmed/31785215 L2 - https://www.ncbi.nlm.nih.gov/pubmed/31785215 N2 - OBJECTIVES: Sleep apnea syndrome affects approximately 4% of adult males and 2% of adult females. It is associated with significant cardio-, cerebrovascular, metabolic and hormonal comorbidities and ranks among the more expensive medical specialties due to the requirement of high-quality technical diagnostic and therapeutic equipment as well as well-educated and experienced personnel. The aim of this study is to detect the relationship between C-reactive protein (CRP), pentraxin-3 (PTX-3), interleukin 6 (IL6), high-sensitivity troponin I (hsTnI), brain natriuretic protein (BNP) and galectin-3 serum levels and obstructive sleep apnea syndrome. DESIGN: Prospective cohort study. MATERIAL AND METHODS: A group of 146 patients with middle to severe obstructive sleep apnea syndrome (OSAS) were monitored, and the results were compared with the results from a control group of healthy individuals. RESULTS: We assessed serum levels of the following biomarkers: CRP, PTX-3, IL6, hsTnI, BNP, and galectin-3. PTX-3 serum levels were statistically significantly higher (p<0.0001) in patients with OSAS, compared to controls. Statistical results related to the other biomarkers did not suggest any clinical value. ROC analysis showed that PTX-3 might be able to distinguish patients with OSAS from healthy individuals (AUC=7438). CONCLUSION: The elevation of PTX-3 serum levels is significantly associated with middle to severe obstructive sleep apnea syndrome. The PTX-3 biomarker appears to be a promising alternative method for sleep apnea syndrome investigations. ER -
SLOUKA, David, Radek KUCERA, Břetislav GÁL, Jaroslav BETKA and Alena SKALOVA. Biomarkers - a possibility for monitoring of obstructive sleep apnea syndrome. \textit{Neuroendocrinology Letters}. Munsbach: Maghira \&{} Maas publications, 2019, vol.~40, No~2, p.~85-92. ISSN~0172-780X.
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