Detailed Information on Publication Record
2018
Family-wide annotation and schematic 2D visualization of secondary structure elements
SVOBODOVÁ VAŘEKOVÁ, Radka, Ivana HUTAŘOVÁ VAŘEKOVÁ, Adam MIDLIK, Jan HUTAŘ, Tarakaramji MOTURU et. al.Basic information
Original name
Family-wide annotation and schematic 2D visualization of secondary structure elements
Authors
SVOBODOVÁ VAŘEKOVÁ, Radka, Ivana HUTAŘOVÁ VAŘEKOVÁ, Adam MIDLIK, Jan HUTAŘ, Tarakaramji MOTURU, Veronika NAVRÁTILOVÁ, Jaroslav KOČA and Karel BERKA
Edition
National Bioinformatic Conference ENBIK, 2018
Other information
Language
English
Type of outcome
Prezentace na konferencích
Field of Study
10608 Biochemistry and molecular biology
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Organization unit
Faculty of Science
Změněno: 22/1/2020 13:12, Mgr. et Mgr. Adam Midlik, Ph.D.
Abstract
V originále
Large amount of structural data is available about individual protein families originating from different organisms, binding various ligands and containing diverse mutations. Secondary structure elements (SSEs) are often characteristic for a protein family and participate in the formation of protein fold. Composition and organization of SSEs can help to identify similarities and differences between proteins within protein families. To utilize the SSEs for research on protein families, we should be able to easily and automatically link and intercompare corresponding SSEs within one protein family. Specifically, the corresponding SSEs should have the same name (annotation) and we need a transparent and coherent schema of their localization in the protein structures, retaining structural information (i.e., minimize a deviation between SSEs distances in 2D schema and in 3D structure). We developed a tool set [1] fulfilling these requirements. It was successfully tested on all CATH families and its utilization in Protein Data Bank and CATH is planned. [1] Svobodová Vařeková, R., Midlik, A., Hutařová Vařeková, I., Hutař, J., Navrátilová, V., Koča, J., Berka, K. (2018). Secondary Structure Elements-Annotations and Schematic 2D Visualizations Stable for Individual Protein Families. Biophys J, 114(3), 46a-47a.