| SÝKOROVÁ, Petra, Jitka NOVOTNÁ, Gabriel DEMO, Guillaume POMPIDOR, Eva DUBSKÁ, Jan KOMÁREK, Eva FUJDIAROVÁ, Josef HOUSER, Lucia HÁRONÍKOVÁ, Annabelle VARROT, Nadya SHILOVA, Anne IMBERTY, Nicolai BOVIN, Martina POKORNÁ and Michaela WIMMEROVÁ. Characterization of novel lectins from Burkholderia pseudomallei and Chromobacterium violaceum with seven-bladed beta-propeller fold. International journal of biological macromolecules. Amsterdam: Elsevier Science BV, 2020, vol. 152, JUN, p. 1113-1124. ISSN 0141-8130. Available from: https://dx.doi.org/10.1016/j.ijbiomac.2019.10.200. |
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@article{1608903,
author = {Sýkorová, Petra and Novotná, Jitka and Demo, Gabriel and Pompidor, Guillaume and Dubská, Eva and Komárek, Jan and Fujdiarová, Eva and Houser, Josef and Hároníková, Lucia and Varrot, Annabelle and Shilova, Nadya and Imberty, Anne and Bovin, Nicolai and Pokorná, Martina and Wimmerová, Michaela},
article_location = {Amsterdam},
article_number = {JUN},
doi = {http://dx.doi.org/10.1016/j.ijbiomac.2019.10.200},
keywords = {lectins; pathoges; Burkholderia pseudomallei; Chromobacterium violaceum},
language = {eng},
issn = {0141-8130},
journal = {International journal of biological macromolecules},
title = {Characterization of novel lectins from Burkholderia pseudomallei and Chromobacterium violaceum with seven-bladed beta-propeller fold},
url = {http://dx.doi.org/10.1016/j.ijbiomac.2019.10.200},
volume = {152},
year = {2020}
}
TY - JOUR
ID - 1608903
AU - Sýkorová, Petra - Novotná, Jitka - Demo, Gabriel - Pompidor, Guillaume - Dubská, Eva - Komárek, Jan - Fujdiarová, Eva - Houser, Josef - Hároníková, Lucia - Varrot, Annabelle - Shilova, Nadya - Imberty, Anne - Bovin, Nicolai - Pokorná, Martina - Wimmerová, Michaela
PY - 2020
TI - Characterization of novel lectins from Burkholderia pseudomallei and Chromobacterium violaceum with seven-bladed beta-propeller fold
JF - International journal of biological macromolecules
VL - 152
IS - JUN
SP - 1113-1124
EP - 1113-1124
PB - Elsevier Science BV
SN - 01418130
KW - lectins
KW - pathoges
KW - Burkholderia pseudomallei
KW - Chromobacterium violaceum
UR - http://dx.doi.org/10.1016/j.ijbiomac.2019.10.200
L2 - http://dx.doi.org/10.1016/j.ijbiomac.2019.10.200
N2 - Burkholderia pseudomallei and Chromobacterium violaceum are bacteria of tropical and subtropical soil and water that occasionally cause fatal infections in humans and animals. Microbial lectins mediate the adhesion of organisms to host cells, which is the first phase in the development of infection. Here we report the discovery of two novel lectins from the above-mentioned bacteria – BP39L and CV39L. The crystal structures revealed that the lectins possess a seven-bladed beta-propeller fold. Functional studies conducted on a series of oligo- and polysaccharides confirmed the preference of BP39L for mannosylated saccharides and CV39L for rather more complex polysaccharides with a monosaccharide preference for beta-L-fucose. The presented data indicate that the proteins belong to a currently unknown family of lectins.
ER -
SÝKOROVÁ, Petra, Jitka NOVOTNÁ, Gabriel DEMO, Guillaume POMPIDOR, Eva DUBSKÁ, Jan KOMÁREK, Eva FUJDIAROVÁ, Josef HOUSER, Lucia HÁRONÍKOVÁ, Annabelle VARROT, Nadya SHILOVA, Anne IMBERTY, Nicolai BOVIN, Martina POKORNÁ and Michaela WIMMEROVÁ. Characterization of novel lectins from Burkholderia pseudomallei and Chromobacterium violaceum with seven-bladed beta-propeller fold. \textit{International journal of biological macromolecules}. Amsterdam: Elsevier Science BV, 2020, vol.~152, JUN, p.~1113-1124. ISSN~0141-8130. Available from: https://dx.doi.org/10.1016/j.ijbiomac.2019.10.200.
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