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@article{1608904,
author = {Kotsarenko, Kateryna and Vechtova, Pavlina and Hammerová, Zuzana and Langová, Natália and Malinovská, Lenka and Wimmerová, Michaela and Sterba, Jan and Grubhoffer, Libor},
article_location = {Munich},
article_number = {2},
doi = {http://dx.doi.org/10.1016/j.ttbdis.2019.101348},
keywords = {DNA methylation; Methyltransferase; 5-Methylcytosine; N6-Methyladenine; Epigenetics; Ixodes tick},
language = {eng},
issn = {1877-959X},
journal = {Ticks and Tick-borne Diseases},
title = {Newly identified DNA methyltransferases of Ixodes ricinus ticks},
url = {https://www.sciencedirect.com/science/article/pii/S1877959X19301992?via%3Dihub},
volume = {11},
year = {2020}
}
TY - JOUR
ID - 1608904
AU - Kotsarenko, Kateryna - Vechtova, Pavlina - Hammerová, Zuzana - Langová, Natália - Malinovská, Lenka - Wimmerová, Michaela - Sterba, Jan - Grubhoffer, Libor
PY - 2020
TI - Newly identified DNA methyltransferases of Ixodes ricinus ticks
JF - Ticks and Tick-borne Diseases
VL - 11
IS - 2
SP - 101348
EP - 101348
PB - Elsevier GmbH
SN - 1877959X
KW - DNA methylation
KW - Methyltransferase
KW - 5-Methylcytosine
KW - N6-Methyladenine
KW - Epigenetics
KW - Ixodes tick
UR - https://www.sciencedirect.com/science/article/pii/S1877959X19301992?via%3Dihub
L2 - https://www.sciencedirect.com/science/article/pii/S1877959X19301992?via%3Dihub
N2 - DNA methylation at the fifth position of cytosine (5mC) and at the sixth position of adenine (6 mA) plays an important role in the regulation of the gene expression and, in eukaryotes, is essential for normal development. For Ixodes ricinus, the most common European arthropod vector of human and animal pathogens, the DNA methylation profile and the role of DNA methylation in tick development are still under discussion. Our goal was to analyze the status of I. ricinus DNA methylation at different life stages and identify enzymes that produce this type of DNA modification. We found that 5mC and 6mA are present in I. ricinus genomic DNA at all life stages. In the transcriptome of I. ricinus, we identified the sequences of the putative IrDNMT1, IrDNMT3, and IrDAMT enzymes, and bioinformatic analysis and three-dimensional modeling predicted their DNA methylation activity. This confirms that I. ricinus possesses a complete DNA methylation toolkit. Our results suggest that DNA methylation is important for the physiology and transstadial development of ticks.
ER -
KOTSARENKO, Kateryna, Pavlina VECHTOVA, Zuzana HAMMEROVÁ, Natália LANGOVÁ, Lenka MALINOVSKÁ, Michaela WIMMEROVÁ, Jan STERBA and Libor GRUBHOFFER. Newly identified DNA methyltransferases of Ixodes ricinus ticks. \textit{Ticks and Tick-borne Diseases}. Munich: Elsevier GmbH, 2020, vol.~11, No~2, p.~101348-101357. ISSN~1877-959X. Available from: https://dx.doi.org/10.1016/j.ttbdis.2019.101348.
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