J 2019

Clinical and laboratory characteristics of enteroviral meningitis in children, including qRT-PCR and sequencing analysis

BRAUNOVÁ, Adriana, Lenka KRBKOVÁ, Petra RAINETOVA, Martin MUSILEK, Iva ČAPOVOVÁ et. al.

Basic information

Original name

Clinical and laboratory characteristics of enteroviral meningitis in children, including qRT-PCR and sequencing analysis

Authors

BRAUNOVÁ, Adriana (203 Czech Republic, guarantor, belonging to the institution), Lenka KRBKOVÁ (203 Czech Republic, belonging to the institution), Petra RAINETOVA (203 Czech Republic), Martin MUSILEK (203 Czech Republic), Iva ČAPOVOVÁ (203 Czech Republic, belonging to the institution), Lenka KLAPAČOVÁ (203 Czech Republic, belonging to the institution), Václav MUSIL (203 Czech Republic, belonging to the institution), Lukáš HOMOLA (203 Czech Republic, belonging to the institution), Tamara KRAVALOVÁ (203 Czech Republic, belonging to the institution), Jana BEDNÁŘOVÁ (203 Czech Republic, belonging to the institution) and Michal KÝR (203 Czech Republic, belonging to the institution)

Edition

Biomedical Papers, Olomouc: Palacky University, Olomouc, Palacky University, 2019, 1213-8118

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30209 Paediatrics

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 1.000

RIV identification code

RIV/00216224:14110/19:00112735

Organization unit

Faculty of Medicine

DOI

UT WoS

000506054400011

Keywords in English

enterovirus; meningitis; children; ECHO virus 30

Tags

Tags

International impact, Reviewed
Změněno: 26/5/2020 10:48, Mgr. Tereza Miškechová

Abstract

V originále

Aims. Enteroviruses (EVs) are the most common agents of aseptic meningitis. Some serotypes can cause serious neuroinfection leading to death. The aim of this study was to determine the representation of EVs in the etiology of aseptic meningitis in children and to analyze the demographic, clinical, laboratory, and epidemiological characteristics of patients with EV meningitis. Patients and Methods. This was a prospective study including 147 patients in three groups: EV meningitis, tick-borne encephalitis, and aseptic meningitis with unidentified agent. Results. Boys with EV meningitis predominated over girls. The average patient age was 11 years. Compared to the control group, these patients suffered more from stiff back (P=0.010), vomiting and nausea (P=0.009). They had shorter symptom duration (P<0.001), higher C-reactive protein in blood (P<0.001), higher predominance of polynuclears (P=0.026), and greater lactate (P=0.003) in cerebrospinal fluid (CSF). The serotype seen most frequently (68%) was ECHO virus (ECV) 30. Conclusions. Enteroviruses play the most important role in the differential diagnosis of aseptic meningitis. Short symptom duration, slightly higher inflammatory parameters in blood, predominance of polynuclears, and elevated CSF lactate have predictive value in diagnosing this disease. ECV 30 (frequently the agent of epidemics in the Czech Republic) was the aseptic meningitis agent most often seen.

Links

MUNI/A/1323/2014, interní kód MU
Name: Enterovirové meningitidy u dětí (Acronym: EMID)
Investor: Masaryk University, Category A
MUNI/A/1586/2018, interní kód MU
Name: Personalizovaná léčba v dětské onkologii: na cestě k "liquid dynamic medecine" a "N-of-1 clinical trials" (Acronym: Personalizovaná léčba v dětské onkologii)
Investor: Masaryk University, Category A