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@article{1609508,
author = {Braunová, Adriana and Krbková, Lenka and Rainetova, Petra and Musilek, Martin and Čapovová, Iva and Klapačová, Lenka and Musil, Václav and Homola, Lukáš and Kravalová, Tamara and Bednářová, Jana and Kýr, Michal},
article_location = {Olomouc},
article_number = {4},
doi = {http://dx.doi.org/10.5507/bp.2018.082},
keywords = {enterovirus; meningitis; children; ECHO virus 30},
language = {eng},
issn = {1213-8118},
journal = {Biomedical Papers, Olomouc: Palacky University},
title = {Clinical and laboratory characteristics of enteroviral meningitis in children, including qRT-PCR and sequencing analysis},
url = {http://dx.doi.org/10.5507/bp.2018.082},
volume = {163},
year = {2019}
}
TY - JOUR
ID - 1609508
AU - Braunová, Adriana - Krbková, Lenka - Rainetova, Petra - Musilek, Martin - Čapovová, Iva - Klapačová, Lenka - Musil, Václav - Homola, Lukáš - Kravalová, Tamara - Bednářová, Jana - Kýr, Michal
PY - 2019
TI - Clinical and laboratory characteristics of enteroviral meningitis in children, including qRT-PCR and sequencing analysis
JF - Biomedical Papers, Olomouc: Palacky University
VL - 163
IS - 4
SP - 355-361
EP - 355-361
PB - Palacky University
SN - 12138118
KW - enterovirus
KW - meningitis
KW - children
KW - ECHO virus 30
UR - http://dx.doi.org/10.5507/bp.2018.082
L2 - http://dx.doi.org/10.5507/bp.2018.082
N2 - Aims. Enteroviruses (EVs) are the most common agents of aseptic meningitis. Some serotypes can cause serious neuroinfection leading to death. The aim of this study was to determine the representation of EVs in the etiology of aseptic meningitis in children and to analyze the demographic, clinical, laboratory, and epidemiological characteristics of patients with EV meningitis. Patients and Methods. This was a prospective study including 147 patients in three groups: EV meningitis, tick-borne encephalitis, and aseptic meningitis with unidentified agent. Results. Boys with EV meningitis predominated over girls. The average patient age was 11 years. Compared to the control group, these patients suffered more from stiff back (P=0.010), vomiting and nausea (P=0.009). They had shorter symptom duration (P<0.001), higher C-reactive protein in blood (P<0.001), higher predominance of polynuclears (P=0.026), and greater lactate (P=0.003) in cerebrospinal fluid (CSF). The serotype seen most frequently (68%) was ECHO virus (ECV) 30. Conclusions. Enteroviruses play the most important role in the differential diagnosis of aseptic meningitis. Short symptom duration, slightly higher inflammatory parameters in blood, predominance of polynuclears, and elevated CSF lactate have predictive value in diagnosing this disease. ECV 30 (frequently the agent of epidemics in the Czech Republic) was the aseptic meningitis agent most often seen.
ER -
BRAUNOVÁ, Adriana, Lenka KRBKOVÁ, Petra RAINETOVA, Martin MUSILEK, Iva ČAPOVOVÁ, Lenka KLAPAČOVÁ, Václav MUSIL, Lukáš HOMOLA, Tamara KRAVALOVÁ, Jana BEDNÁŘOVÁ and Michal KÝR. Clinical and laboratory characteristics of enteroviral meningitis in children, including qRT-PCR and sequencing analysis. \textit{Biomedical Papers, Olomouc: Palacky University}. Olomouc: Palacky University, 2019, vol.~163, No~4, p.~355-361. ISSN~1213-8118. Available from: https://dx.doi.org/10.5507/bp.2018.082.
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