J 2019

Sensory profiles and immune-related expression patterns of patients with and without neuropathic pain after peripheral nerve lesion

HELD, Melissa, Franziska KARL, Eva VLČKOVÁ, Aneta RAJDOVÁ, Fabiola ESCOLANO-LOZANO et. al.

Basic information

Original name

Sensory profiles and immune-related expression patterns of patients with and without neuropathic pain after peripheral nerve lesion

Authors

HELD, Melissa (276 Germany), Franziska KARL (276 Germany), Eva VLČKOVÁ (203 Czech Republic, belonging to the institution), Aneta RAJDOVÁ (203 Czech Republic, belonging to the institution), Fabiola ESCOLANO-LOZANO (276 Germany), Christian STETTER (276 Germany), Richa BHARTI (276 Germany), Konrad U. FÖRSTNER (276 Germany), Ladislav DUŠEK (203 Czech Republic, belonging to the institution), Mathias LEINDERS (276 Germany), Frank BIRKLEIN (276 Germany), Josef BEDNAŘÍK (203 Czech Republic, belonging to the institution), Claudia SOMMER (276 Germany) and Nurcan ÜÇEYLER (guarantor)

Edition

Pain, LIPPINCOTT WILLIAMS & WILKINS, 2019, 0304-3959

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 5.483

RIV identification code

RIV/00216224:14110/19:00112744

Organization unit

Faculty of Medicine

DOI

UT WoS

000512905700016

Keywords in English

Nerve lesion; Neuropathic pain; Sensory profile; Quantitative sensory testing; mRNA

Tags

Tags

International impact, Reviewed
Změněno: 2/3/2020 08:52, Mgr. Tereza Miškechová

Abstract

V originále

In this multicenter cross-sectional study, we determined sensory profiles of patients with (NL-1) and without neuropathic pain (NL-0) after nerve lesion and assessed immune-related systemic gene expression. Patients and matched healthy controls filled in questionnaires and underwent neurological examination, neurophysiological studies, quantitative sensory testing, and blood withdrawal. Neuropathic pain was present in 67/95 (71%) patients (NL-1). Tactile hyperalgesia was the most prominent clinical sign in NL-1 patients (P , 0.05). Questionnaires showed an association between neuropathic pain and the presence of depression, anxiety, and catastrophizing (P , 0.05 to P , 0.01). Neuropathic pain was frequently accompanied by other chronic pain (P , 0.05). Quantitative sensory testing showed ipsilateral signs of small and large fiber impairment compared to the respective contralateral side, with elevated thermal and mechanical detection thresholds (P , 0.001 to P , 0.05) and lowered pressure pain threshold (P , 0.05). Also, more loss of function was found in patients with NL-1 compared to NL-0. Pain intensity was associated with mechanical hyperalgesia (P , 0.05 to P , 0.01). However, quantitative sensory testing did not detect or predict neuropathic pain. Gene expression of peptidylglycine a-amidating monooxygenase was higher in NL patients compared with healthy controls (NL-1, P , 0.01; NL-0, P , 0.001). Also, gene expression of tumor necrosis factor-a was higher in NL-1 patients compared with NL-0 (P , 0.05), and interleukin-1ß was higher, but IL-10 was lower in NL-1 patients compared with healthy controls (P , 0.05 each). Our study reveals that nerve lesion presents with small and large nerve fiber dysfunction, which may contribute to the presence and intensity of neuropathic pain and which is associated with a systemic proinflammatory pattern.

Links

MUNI/A/1419/2018, interní kód MU
Name: Diagnostika a patofyziologie neuropatické bolesti (Acronym: PNB)
Investor: Masaryk University, Category A
602133, interní kód MU
Name: ncRNAPain - Non-coding RNAs in neurogenic and neuropathic pain mechanisms and their application for risk assessment, patient stratification and personalised pain medicine (Acronym: ncRNAPain)
Investor: European Union, Cooperation