Non-invasive estimation of arterial stiffness in healthy and asthmatic children: a pilot study.

TINKA, Pavel, Hedda Asia HANSEN, Ksenia BUDINSKAYA, Vojtěch SVÍZELA, Jana SVAČINOVÁ, Jana RÝDLOVA, Hana HRSTKOVÁ, Petr DOBŠÁK and Zuzana NOVÁKOVÁ. Non-invasive estimation of arterial stiffness in healthy and asthmatic children: a pilot study. 2019.

Basic information

• Original name: Non-invasive estimation of arterial stiffness in healthy and asthmatic children: a pilot study.
• Authors: TINKA, Pavel, Hedda Asia HANSEN, Ksenia BUDINSKAYA, Vojtěch SVÍZELA, Jana SVAČINOVÁ, Jana RÝDLOVA, Hana HRSTKOVÁ, Petr DOBŠÁK and Zuzana NOVÁKOVÁ.
• Edition: 2019.

Other information

• Type of outcome: Conference abstract
• Confidentiality degree: is not subject to a state or trade secret
• Keywords in English: Arterial stiffness, Asthma bronchiale

Abstract

Introduction: Asthma is a chronic airway inflammatory disease that can have potential systemic impact on all organ systems. The “golden” standard for evaluation of cardiovascular system (CVS) functions are parameters: systolic (SBP) and diastolic (DBP) blood pressures and arterial stiffness measurement. The aim of our study: to evaluate functional and structural changes in CVS in asthmatic patients with compare to healthy children. Methods: We measured 52 asthmatic children (group A, 23 boys) and 71 heathy control (group C, 34 boys); age (14±2 years old), body mass index (BMI: 21.1±4.6kg/m2). For each respondent we measured SBP and DBP (Omron, HEM-907-E, Japan). For estimation cardiovascular parameters we used applanation tonometry (Sphygmocor device, AtCor Medical, Australia; vascular parameters: pulse wave velocity-PWV, augmentation pressure-AP and index-AI; parameters of cardiac function: central tension time index-TTI, central diastolic time index-DTI, central Buckberg index-SEVR, [%]. Such vascular parameters as cardio ankle vascular index (CAVI) and ankle brachial index (ABI) were measured on the both side with VaSera device (Fukuda Denshi, Tokyo, Japan. Results: There were significant differences in PWV (6.6±1.1vs.7.2±1.4 m/s; p<0.05), CAVIR (4.4±0.9 vs. 4.8±0.6; p<0.05), CAVIL (4.5±0.7vs.4.9±0.6; p<0.01), ABIL (0.9±0.1vs.0.95±0.1; p<0.01), TTI (1980±282.0vs.1697±334.8; p<0.01), SEVR (135.5±24.2vs.153±37.7 %; p<0.01) between A and C. There is no significant difference in SBP (107.5±13.2 vs. 111±12.4 mmHg; NS) and DBP (62±8 vs. 61±8.7mmHg; NS) between A and C. Conclusion: We can conclude that asthma bronchiale and its treatment changed the properties of vessels in children comparing to the healthy group, as well as parameters of cardiac function.

Links

• MUNI/A/1255/2018, interní kód MU: Name: Kardiovaskulární systém a jeho regulace a dysregulace pod vlivem farmak (Acronym: KAREDYSFAR)

Investor: Masaryk University, Category A