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@article{1611579,
author = {Filip, Daniel and Mráz, Marek},
article_location = {LONDON},
article_number = {3},
doi = {http://dx.doi.org/10.1080/10428194.2019.1675877},
keywords = {Lymphomas; indolent mature B-cell malignancies; transformation; MYC; microRNA},
language = {eng},
issn = {1042-8194},
journal = {LEUKEMIA & LYMPHOMA},
title = {The role of MYC in the transformation and aggressiveness of ?indolent? B-cell malignancies},
url = {https://www.tandfonline.com/doi/full/10.1080/10428194.2019.1675877},
volume = {61},
year = {2020}
}
TY - JOUR
ID - 1611579
AU - Filip, Daniel - Mráz, Marek
PY - 2020
TI - The role of MYC in the transformation and aggressiveness of ?indolent? B-cell malignancies
JF - LEUKEMIA & LYMPHOMA
VL - 61
IS - 3
SP - 510-524
EP - 510-524
PB - INFORMA HEALTHCARE
SN - 10428194
KW - Lymphomas
KW - indolent mature B-cell malignancies
KW - transformation
KW - MYC
KW - microRNA
UR - https://www.tandfonline.com/doi/full/10.1080/10428194.2019.1675877
N2 - MYC was found to be involved in many germinal center derived lymphomas, and more recently in the histological transformation of indolent mature B-cell malignancies, such as follicular lymphoma (FL), chronic lymphocytic leukemia (CLL) and mucosa-associated lymphoid tissue lymphoma (MALT) to aggressive diffuse large B-cell lymphoma (DLBCL). Pathological MYC activity gain in lymphomas is able to overcome its regulation by repressors, which leads to bypassing the affinity-based selection of B-cells. Arguably the MYC activity gain is the most constantly observed phenomenon (>70% of cases) in transformed FL/MALT/CLL (Richter?s transformation) and co-occurs with specific aberrations such as the loss of p53, CDKN2A/B, or gain of BCL2/BCL6. Here we summarize recent progress in the understanding of MYC regulatory network in lymphoma B-cells and highlight its involvement in lymphomas? histological transformation by regulating cyclins, CDKs, p21, p27, BCL2, E2F, FOXP1, BCR signaling components, and non-coding microRNA (miRNA) genes such as miR-150, miR-29, miR-17-92, and miR-34a.
ER -
FILIP, Daniel and Marek MRÁZ. The role of MYC in the transformation and aggressiveness of ?indolent? B-cell malignancies. \textit{LEUKEMIA \&{} LYMPHOMA}. LONDON: INFORMA HEALTHCARE, 2020, vol.~61, No~3, p.~510-524. ISSN~1042-8194. Available from: https://dx.doi.org/10.1080/10428194.2019.1675877.
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