The role of MYC in the transformation and aggressiveness of
?indolent? B-cell malignancies

J 2020

The role of MYC in the transformation and aggressiveness of ?indolent? B-cell malignancies

FILIP, Daniel and Marek MRÁZ

Basic information

Original name

The role of MYC in the transformation and aggressiveness of ?indolent? B-cell malignancies

Authors

FILIP, Daniel (703 Slovakia, belonging to the institution) and Marek MRÁZ (203 Czech Republic, guarantor, belonging to the institution)

Edition

LEUKEMIA & LYMPHOMA, LONDON, INFORMA HEALTHCARE, 2020, 1042-8194

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.280

RIV identification code

RIV/00216224:14740/20:00118594

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1080/10428194.2019.1675877

UT WoS

000491844800001

Keywords in English

Lymphomas; indolent mature B-cell malignancies; transformation; MYC; microRNA

Abstract

V originále

MYC was found to be involved in many germinal center derived lymphomas, and more recently in the histological transformation of indolent mature B-cell malignancies, such as follicular lymphoma (FL), chronic lymphocytic leukemia (CLL) and mucosa-associated lymphoid tissue lymphoma (MALT) to aggressive diffuse large B-cell lymphoma (DLBCL). Pathological MYC activity gain in lymphomas is able to overcome its regulation by repressors, which leads to bypassing the affinity-based selection of B-cells. Arguably the MYC activity gain is the most constantly observed phenomenon (>70% of cases) in transformed FL/MALT/CLL (Richter?s transformation) and co-occurs with specific aberrations such as the loss of p53, CDKN2A/B, or gain of BCL2/BCL6. Here we summarize recent progress in the understanding of MYC regulatory network in lymphoma B-cells and highlight its involvement in lymphomas? histological transformation by regulating cyclins, CDKs, p21, p27, BCL2, E2F, FOXP1, BCR signaling components, and non-coding microRNA (miRNA) genes such as miR-150, miR-29, miR-17-92, and miR-34a.

Links

NV18-03-00054, research and development project

Name: ÚLOHA MICRORNA A JEJICH CÍLOVÝCH MOLEKUL V TRANSFORMACI FOLIKULÁRNÍHO LYMFOMU A AGRESIVITĚ CHRONICKÉ LYMFOCYTÁRNÍ LEUKÉMIE

Investor: Ministry of Health of the CR

Citovat

FILIP, Daniel and Marek MRÁZ. The role of MYC in the transformation and aggressiveness of ?indolent? B-cell malignancies. LEUKEMIA & LYMPHOMA. LONDON: INFORMA HEALTHCARE, 2020, vol. 61, No 3, p. 510-524. ISSN 1042-8194. Available from: https://dx.doi.org/10.1080/10428194.2019.1675877.

@article{1611579,
   author = {Filip, Daniel and Mráz, Marek},
   article_location = {LONDON},
   article_number = {3},
   doi = {http://dx.doi.org/10.1080/10428194.2019.1675877},
   keywords = {Lymphomas; indolent mature B-cell malignancies; transformation; MYC; microRNA},
   language = {eng},
   issn = {1042-8194},
   journal = {LEUKEMIA & LYMPHOMA},
   title = {The role of MYC in the transformation and aggressiveness of ?indolent? B-cell malignancies},
   url = {https://www.tandfonline.com/doi/full/10.1080/10428194.2019.1675877},
   volume = {61},
   year = {2020}
}

TY  - JOUR
ID  - 1611579
AU  - Filip, Daniel - Mráz, Marek
PY  - 2020
TI  - The role of MYC in the transformation and aggressiveness of ?indolent? B-cell malignancies
JF  - LEUKEMIA & LYMPHOMA
VL  - 61
IS  - 3
SP  - 510-524
EP  - 510-524
PB  - INFORMA HEALTHCARE
SN  - 10428194
KW  - Lymphomas
KW  - indolent mature B-cell malignancies
KW  - transformation
KW  - MYC
KW  - microRNA
UR  - https://www.tandfonline.com/doi/full/10.1080/10428194.2019.1675877
N2  - MYC was found to be involved in many germinal center derived lymphomas, and more recently in the histological transformation of indolent mature B-cell malignancies, such as follicular lymphoma (FL), chronic lymphocytic leukemia (CLL) and mucosa-associated lymphoid tissue lymphoma (MALT) to aggressive diffuse large B-cell lymphoma (DLBCL). Pathological MYC activity gain in lymphomas is able to overcome its regulation by repressors, which leads to bypassing the affinity-based selection of B-cells. Arguably the MYC activity gain is the most constantly observed phenomenon (>70% of cases) in transformed FL/MALT/CLL (Richter?s transformation) and co-occurs with specific aberrations such as the loss of p53, CDKN2A/B, or gain of BCL2/BCL6. Here we summarize recent progress in the understanding of MYC regulatory network in lymphoma B-cells and highlight its involvement in lymphomas? histological transformation by regulating cyclins, CDKs, p21, p27, BCL2, E2F, FOXP1, BCR signaling components, and non-coding microRNA (miRNA) genes such as miR-150, miR-29, miR-17-92, and miR-34a.
ER  -

FILIP, Daniel and Marek MRÁZ. The role of MYC in the transformation and aggressiveness of ?indolent? B-cell malignancies. \textit{LEUKEMIA \&{} LYMPHOMA}. LONDON: INFORMA HEALTHCARE, 2020, vol.~61, No~3, p.~510-524. ISSN~1042-8194. Available from: https://dx.doi.org/10.1080/10428194.2019.1675877.

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