J 2020

The role of MYC in the transformation and aggressiveness of ?indolent? B-cell malignancies

FILIP, Daniel and Marek MRÁZ

Basic information

Original name

The role of MYC in the transformation and aggressiveness of ?indolent? B-cell malignancies

Authors

FILIP, Daniel (703 Slovakia, belonging to the institution) and Marek MRÁZ (203 Czech Republic, guarantor, belonging to the institution)

Edition

LEUKEMIA & LYMPHOMA, LONDON, INFORMA HEALTHCARE, 2020, 1042-8194

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 3.280

RIV identification code

RIV/00216224:14740/20:00118594

Organization unit

Central European Institute of Technology

UT WoS

000491844800001

Keywords in English

Lymphomas; indolent mature B-cell malignancies; transformation; MYC; microRNA

Tags

International impact, Reviewed
Změněno: 12/5/2021 12:44, Mgr. Pavla Foltynová, Ph.D.

Abstract

V originále

MYC was found to be involved in many germinal center derived lymphomas, and more recently in the histological transformation of indolent mature B-cell malignancies, such as follicular lymphoma (FL), chronic lymphocytic leukemia (CLL) and mucosa-associated lymphoid tissue lymphoma (MALT) to aggressive diffuse large B-cell lymphoma (DLBCL). Pathological MYC activity gain in lymphomas is able to overcome its regulation by repressors, which leads to bypassing the affinity-based selection of B-cells. Arguably the MYC activity gain is the most constantly observed phenomenon (>70% of cases) in transformed FL/MALT/CLL (Richter?s transformation) and co-occurs with specific aberrations such as the loss of p53, CDKN2A/B, or gain of BCL2/BCL6. Here we summarize recent progress in the understanding of MYC regulatory network in lymphoma B-cells and highlight its involvement in lymphomas? histological transformation by regulating cyclins, CDKs, p21, p27, BCL2, E2F, FOXP1, BCR signaling components, and non-coding microRNA (miRNA) genes such as miR-150, miR-29, miR-17-92, and miR-34a.

Links

NV18-03-00054, research and development project
Name: ÚLOHA MICRORNA A JEJICH CÍLOVÝCH MOLEKUL V TRANSFORMACI FOLIKULÁRNÍHO LYMFOMU A AGRESIVITĚ CHRONICKÉ LYMFOCYTÁRNÍ LEUKÉMIE
Investor: Ministry of Health of the CR