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@article{1612096,
author = {Hruška, Pavel and Kuruczová, Daniela and Vašků, Vladimír and Dobrovolná, Julie},
article_location = {San Francisco},
article_number = {6},
doi = {http://dx.doi.org/10.1371/journal.pone.0218323},
keywords = {SYSTEMIC-LUPUS-ERYTHEMATOSUS; FUNCTIONAL POLYMORPHISM; INFLAMMATORY RESPONSES; GENETIC ASSOCIATION; MICRORNA-BINDING; EXPRESSION; RISK; MIR-146A; CD11B/CD18; LEUKOCYTES},
language = {eng},
issn = {1932-6203},
journal = {Plos one},
title = {MiR-21 binding site SNP within ITGAM associated with psoriasis susceptibility in women},
url = {http://dx.doi.org/10.1371/journal.pone.0218323},
volume = {14},
year = {2019}
}
TY - JOUR
ID - 1612096
AU - Hruška, Pavel - Kuruczová, Daniela - Vašků, Vladimír - Dobrovolná, Julie
PY - 2019
TI - MiR-21 binding site SNP within ITGAM associated with psoriasis susceptibility in women
JF - Plos one
VL - 14
IS - 6
SP - 1-11
EP - 1-11
PB - Public Library of Science
SN - 19326203
KW - SYSTEMIC-LUPUS-ERYTHEMATOSUS
KW - FUNCTIONAL POLYMORPHISM
KW - INFLAMMATORY RESPONSES
KW - GENETIC ASSOCIATION
KW - MICRORNA-BINDING
KW - EXPRESSION
KW - RISK
KW - MIR-146A
KW - CD11B/CD18
KW - LEUKOCYTES
UR - http://dx.doi.org/10.1371/journal.pone.0218323
L2 - http://dx.doi.org/10.1371/journal.pone.0218323
N2 - Background Great progress has been made in the understanding of inflammatory processes in psoriasis. However, clarifying the role of genetic variability in processes regulating inflammation, including post-transcriptional regulation by microRNA (miRNA), remains a challenge. Objectives We therefore investigated single nucleotide polymorphisms (SNPs) with a predicted change in the miRNA/mRNA interaction of genes involved in the psoriasis inflammatory processes. Methods Studied SNPs rs2910164 C/G-miR-146a, rs4597342 T/C-ITGAM, rs1368439 G/T-IL12B, rs1468488 C/T-IL17RA were selected using a bioinformatics analysis of psoriasis inflammation-associated genes. These SNPs were then genotyped using a large cohort of women with psoriasis (n = 241) and healthy controls (n = 516). Results No significant association with psoriasis was observed for rs2910164, rs1368439, and rs1468488 genotypes. However, the major allele T of rs4597342 -ITGAM was associated with approximately 28% higher risk for psoriasis in comparison to the patients with the C allele (OR = 1.28, 95% CI 1.01-1.61, p = 0.037). In case of genotypes, the effect of the T allele indicates the dominant model of disease penetrance as the CT and TT genotypes increase the chance of psoriasis up to 42% in comparison to CC homozygotes of rs4597342 (OR = 1.42, 95% CI = 1.05-1.94, p = 0.025). Conclusion SNP rs4597342 in 3'UTR of ITGAM influencing miR-21 binding may be considered a risk factor for psoriasis development. Upregulated miR-21 in psoriasis is likely to inhibit CD11b production in the case of the rs4597342 T allele which may lead to Mac-1 dysfunction, resulting in an aberrant function of innate immune cells and leading to the production of cytokines involved in psoriasis pathogenesis.
ER -
HRUŠKA, Pavel, Daniela KURUCZOVÁ, Vladimír VAŠKŮ and Julie DOBROVOLNÁ. MiR-21 binding site SNP within ITGAM associated with psoriasis susceptibility in women. \textit{Plos one}. San Francisco: Public Library of Science, 2019, vol.~14, No~6, p.~1-11. ISSN~1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0218323.
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