| ROSLI, Nur Farhanah, Michaela FOJTŮ, Adrian C. FISHER and Martin PUMERA. Graphene Oxide Nanoplatelets Potentiate Anticancer Effect of Cisplatin in Human Lung Cancer Cells. Langmuir. WASHINGTON: AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA, 2019, vol. 35, No 8, p. 3176-3182. ISSN 0743-7463. Available from: https://dx.doi.org/10.1021/acs.langmuir.8b03086. |
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@article{1612196,
author = {Rosli, Nur Farhanah and Fojtů, Michaela and Fisher, Adrian C. and Pumera, Martin},
article_location = {WASHINGTON},
article_number = {8},
doi = {http://dx.doi.org/10.1021/acs.langmuir.8b03086},
keywords = {TARGETED DELIVERY; CYTOTOXICITY; TOXICITY; NANOCARRIER; LABELS},
language = {eng},
issn = {0743-7463},
journal = {Langmuir},
title = {Graphene Oxide Nanoplatelets Potentiate Anticancer Effect of Cisplatin in Human Lung Cancer Cells},
url = {http://dx.doi.org/10.1021/acs.langmuir.8b03086},
volume = {35},
year = {2019}
}
TY - JOUR
ID - 1612196
AU - Rosli, Nur Farhanah - Fojtů, Michaela - Fisher, Adrian C. - Pumera, Martin
PY - 2019
TI - Graphene Oxide Nanoplatelets Potentiate Anticancer Effect of Cisplatin in Human Lung Cancer Cells
JF - Langmuir
VL - 35
IS - 8
SP - 3176-3182
EP - 3176-3182
PB - AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN - 07437463
KW - TARGETED DELIVERY
KW - CYTOTOXICITY
KW - TOXICITY
KW - NANOCARRIER
KW - LABELS
UR - http://dx.doi.org/10.1021/acs.langmuir.8b03086
L2 - http://dx.doi.org/10.1021/acs.langmuir.8b03086
N2 - Graphene oxide (GO) has been widely explored by many in drug delivery strategies and toxicity assays. The toxicity of graphene oxide depends on the size of the sheets. Smaller sheets show lower toxicity, a quality which is essential for utilization in biomedical applications. However, despite vast research on GO, anticancer properties and drug carrier capabilities of graphene oxide nanoplatelets have yet to be fully explored. Herein, we have uniquely prepared graphene oxide nanoplatelets (GONPs) from well-defined stacked graphite nanofibers (SGNF) with a base of 50 x 50 nm(2) for toxicity and drug potentiation studies when coadministered with the chemotherapeutic drug cisplatin (CP) in human lung cancer cells, A549 cells. Results obtained from our studies have found that not only were GONPs able to act as drug carriers, but they can also significantly potentiate anticancer effect of CP in A549 cells.
ER -
ROSLI, Nur Farhanah, Michaela FOJTŮ, Adrian C. FISHER and Martin PUMERA. Graphene Oxide Nanoplatelets Potentiate Anticancer Effect of Cisplatin in Human Lung Cancer Cells. \textit{Langmuir}. WASHINGTON: AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA, 2019, vol.~35, No~8, p.~3176-3182. ISSN~0743-7463. Available from: https://dx.doi.org/10.1021/acs.langmuir.8b03086.
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