J 2019

Prospective Observational Cohort Study to Describe the Use of Panitumumab in Combination with Chemotherapy in Real-World Clinical Practice for Patients with Wild-Type RAS mCRC

HEBART, Holger, Michael KIEHL, Jiří TOMÁŠEK, Tibor CSOSZI, Reija KOUKAKIS et. al.

Basic information

Original name

Prospective Observational Cohort Study to Describe the Use of Panitumumab in Combination with Chemotherapy in Real-World Clinical Practice for Patients with Wild-Type RAS mCRC

Authors

HEBART, Holger (276 Germany, guarantor), Michael KIEHL (276 Germany), Jiří TOMÁŠEK (203 Czech Republic, belonging to the institution), Tibor CSOSZI (348 Hungary), Reija KOUKAKIS (826 United Kingdom of Great Britain and Northern Ireland), George KAFATOS (826 United Kingdom of Great Britain and Northern Ireland), Anja KUHN (276 Germany), Katja BJORKLOF (756 Switzerland), Gaston DEMONTY (56 Belgium) and Tomáš BÜCHLER (203 Czech Republic)

Edition

ADVANCES IN THERAPY, NEW YORK, SPRINGER, 2019, 0741-238X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 3.871

RIV identification code

RIV/00216224:14110/19:00112792

Organization unit

Faculty of Medicine

DOI

UT WoS

000462129500013

Keywords in English

Metastatic colorectal cancer; Observational study; Panitumumab; RAS wild-type; Real-world data; Tumor location

Tags

Tags

International impact, Reviewed
Změněno: 28/1/2020 11:17, Mgr. Tereza Miškechová

Abstract

V originále

Introduction: This study aimed to better understand panitumumab use in real-life clinical practice in first- and second-line treatment of metastatic colorectal cancer in five European countries. Methods: This is a combined analysis of two observational, non-interventional prospective cohort studies, one of which was conducted in Germany and France, the other in Bulgaria, Czech Republic, and Hungary. The studies observed patients with wild-type [Kirsten] rat sarcoma viral oncogene homolog ([K]RAS/RAS) metastatic colorectal cancer (mCRC), who had been treated with panitumumab in combination with fluorouracil, leucovorin, and oxaliplatin (FOLFOX) in the first line or with panitumumab combined with fluorouracil, leucovorin, and irinotecan (FOLFIRI) in the second line following fluoropyrimidine-based chemotherapy. The planned duration of observation was 12months from the first dose of panitumumab. Results: A total of 332 patients treated with panitumumab+FOLFOX in the first line and 94 patients treated with panitumumab+FOLFIRI in the second line were analyzed. The median number of panitumumab infusions was 10.0 in first-line FOLFOX patients and 11.5 in second-line FOLFIRI patients; the median duration of panitumumab exposure was 5.7 and 6.9months, respectively. The unadjusted overall response rate (complete or partial response) in patients with available post-baseline response assessment (n=290) was 51.7% in first-line FOLFOX and 44.9% in second-line FOLFIRI patients. In the first-line setting, resectability was achieved in 9.3%. Reported hospitalizations were mostly cancer-related visits such as scheduled anticancer treatment administrations, tumor assessment visits, or interventions. The majority of adverse drug reactions were skin disorders, with 75.3% in first-line FOLFOX patients and 72.3% in second-line FOLFIRI patients. Conclusion: Overall, the study results show that treatment patterns, clinical efficacy, and the safety profile of panitumumab in routine clinical practice were comparable to those in randomized controlled trials. The relatively low skin toxicity rate could be attributed to increasing experience in managing panitumumab-associated rash and some degree of underreporting.