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@article{1612320,
author = {Hebart, Holger and Kiehl, Michael and Tomášek, Jiří and Csoszi, Tibor and Koukakis, Reija and Kafatos, George and Kuhn, Anja and Bjorklof, Katja and Demonty, Gaston and Büchler, Tomáš},
article_location = {NEW YORK},
article_number = {3},
doi = {http://dx.doi.org/10.1007/s12325-019-0874-6},
keywords = {Metastatic colorectal cancer; Observational study; Panitumumab; RAS wild-type; Real-world data; Tumor location},
language = {eng},
issn = {0741-238X},
journal = {ADVANCES IN THERAPY},
title = {Prospective Observational Cohort Study to Describe the Use of Panitumumab in Combination with Chemotherapy in Real-World Clinical Practice for Patients with Wild-Type RAS mCRC},
url = {http://dx.doi.org/10.1007/s12325-019-0874-6},
volume = {36},
year = {2019}
}
TY - JOUR
ID - 1612320
AU - Hebart, Holger - Kiehl, Michael - Tomášek, Jiří - Csoszi, Tibor - Koukakis, Reija - Kafatos, George - Kuhn, Anja - Bjorklof, Katja - Demonty, Gaston - Büchler, Tomáš
PY - 2019
TI - Prospective Observational Cohort Study to Describe the Use of Panitumumab in Combination with Chemotherapy in Real-World Clinical Practice for Patients with Wild-Type RAS mCRC
JF - ADVANCES IN THERAPY
VL - 36
IS - 3
SP - 670-683
EP - 670-683
PB - SPRINGER
SN - 0741238X
KW - Metastatic colorectal cancer
KW - Observational study
KW - Panitumumab
KW - RAS wild-type
KW - Real-world data
KW - Tumor location
UR - http://dx.doi.org/10.1007/s12325-019-0874-6
L2 - http://dx.doi.org/10.1007/s12325-019-0874-6
N2 - Introduction: This study aimed to better understand panitumumab use in real-life clinical practice in first- and second-line treatment of metastatic colorectal cancer in five European countries. Methods: This is a combined analysis of two observational, non-interventional prospective cohort studies, one of which was conducted in Germany and France, the other in Bulgaria, Czech Republic, and Hungary. The studies observed patients with wild-type [Kirsten] rat sarcoma viral oncogene homolog ([K]RAS/RAS) metastatic colorectal cancer (mCRC), who had been treated with panitumumab in combination with fluorouracil, leucovorin, and oxaliplatin (FOLFOX) in the first line or with panitumumab combined with fluorouracil, leucovorin, and irinotecan (FOLFIRI) in the second line following fluoropyrimidine-based chemotherapy. The planned duration of observation was 12months from the first dose of panitumumab. Results: A total of 332 patients treated with panitumumab+FOLFOX in the first line and 94 patients treated with panitumumab+FOLFIRI in the second line were analyzed. The median number of panitumumab infusions was 10.0 in first-line FOLFOX patients and 11.5 in second-line FOLFIRI patients; the median duration of panitumumab exposure was 5.7 and 6.9months, respectively. The unadjusted overall response rate (complete or partial response) in patients with available post-baseline response assessment (n=290) was 51.7% in first-line FOLFOX and 44.9% in second-line FOLFIRI patients. In the first-line setting, resectability was achieved in 9.3%. Reported hospitalizations were mostly cancer-related visits such as scheduled anticancer treatment administrations, tumor assessment visits, or interventions. The majority of adverse drug reactions were skin disorders, with 75.3% in first-line FOLFOX patients and 72.3% in second-line FOLFIRI patients. Conclusion: Overall, the study results show that treatment patterns, clinical efficacy, and the safety profile of panitumumab in routine clinical practice were comparable to those in randomized controlled trials. The relatively low skin toxicity rate could be attributed to increasing experience in managing panitumumab-associated rash and some degree of underreporting.
ER -
HEBART, Holger, Michael KIEHL, Jiří TOMÁŠEK, Tibor CSOSZI, Reija KOUKAKIS, George KAFATOS, Anja KUHN, Katja BJORKLOF, Gaston DEMONTY and Tomáš BÜCHLER. Prospective Observational Cohort Study to Describe the Use of Panitumumab in Combination with Chemotherapy in Real-World Clinical Practice for Patients with Wild-Type RAS mCRC. \textit{ADVANCES IN THERAPY}. NEW YORK: SPRINGER, 2019, vol.~36, No~3, p.~670-683. ISSN~0741-238X. Available from: https://dx.doi.org/10.1007/s12325-019-0874-6.
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